Table 2 Comparison of clinical presentation and therapy provided between 2009 pandemic and post-pandemic Influenza (H1N1)v infection period.

APACHE II score.

Mean (SD)

13.9 +/- 7.2

16.3 +/- 7.7

<0.001

SOFA score.

Mean (SD)

5.6 +/- 3.6

6.2 +/- 4.1

0.04

Clinical presentation

Primary viral pneumonia

451 (69.6)

237 (67.9)

0.5

COPD exacerbation

36 (5.6)

24 (6.9)

0.4

Community acquired respiratory co-infection

107 (16.5)

69 (19.8)

0.2

Secondary respiratory infections

57 (9.3)

16 (4.7)

0.006

Days from symptoms onset to hospital admission, Mean (SD)

4.2 +/- 2.6

4.8 +/- 3.4

0.004

Days from hospitalization to diagnosis, Mean (SD)

2.3 +/- 2.1

6.5 +/- 3.8

<0.001

Clinical failure

Septic shock

294 (45.4)

190 (54.4)

0.006

MODS

405 (62.5)

199 (57)

0.09

Mechanical ventilation

465 (71.8)

282 (80.8)

<0.001

Invasive mechanical ventilation

398 (61.4)

233 (66.8)

0.09

Non-invasive mechanical ventilation

163 (25.2)

115 (33)

<0.001

Prone positioning

95 (14.7)

67 (19.2)

0.06

Septic shock

294 (45.4)

190 (54.4)

0.007

Acute kidney Injury

130 (20.1)

95 (27.2)

<0.001

Continuous renal replacement therapy

53 (8.2)

45 (12.9)

<0.001

Therapy administered

Empirical oseltamivir

631 (99.1)

339 (97.4)

0.04

Days from symptoms onset to oseltamivir administration

4.7 (2.9)

5.6 (3.5)

<0.001

Zanamivir

4 (0.6)

25 (7.2)

<0.001

ICU mortality

141 (21.8)

105 (30.1)

0.004