Skip to main content

Table 1 Characteristics of the studies included in the systematic review

From: Vasopressin and terlipressin in adult vasodilatory shock: a systematic review and meta-analysis of nine randomized controlled trials

Study

Arms

n

Age (years)

Design

Disease

Dosage

Prognostic index

Time (hours)

MAP objective (mmHg)

Albanèse and colleagues [6]

N

10

65

RCT

Septic shock

119 μg/minute

29 (APACHE II)

6

65 ± 10

 

TP

10

66

OL

 

50 μg/hour

28 (APACHE II)

6

 

Dünser and colleagues [7]

N

24

68

RCT

Vasodilatory shock

58.8 μg/minute

49.7 (SAPS II)

48

>70

 

N+AV

24

68

OL

(PS in 40%)

0.06 U/minute

51.6 (SAPS II)

48

 

Morelli and colleagues [8]

N

15

64

RCT

Septic shock

15 μg/minute

58 (SAPS II)

48

70 ± 5

 

N+TP

15

67

OL

 

110.5 μg/hour

62 (SAPS II)

48

 
 

N+AV

15

66

  

0.03 U/min

60 (SAPS II)

48

 

Morelli and colleagues [9]

N

20

67

RCT

Septic shock

84 μg/minute

59 (SAPS II)

4

70 ± 5

 

N+TP

19

66

OL

(N >0.9 μg/kg/minute)

16.6 μg/hour

60 (SAPS II)

4

 

Russell and colleagues [10]

N

382

62

RCT

Septic shock

15 μg/minute

27.1 (APACHE II)

672

65 ± 10

 

N+AV

397

59

DB

(N >5 μg/minute)

0.03 U/minute

27 (APACHE II)

672

 

Argenziano and colleagues [11]

N+P

5

52

RCT

Vasodilatory shock

19.7 μg/minute

-

0.25

>70

 

N+AV

5

52

DB

Post-LVAD

0.1 U/minute

 

0.25

 

Patel and colleagues [12]

N

11

68

RCT

Septic shock

17 μg/minute

24 (APACHE II)

4

Physician decision

 

N+AV

13

68

DB

(high doses of D)

0.06 U/minute

22 (APACHE II)

4

 

Malay and colleagues [13]

N+P

5

56

RCT

Septic shock

12 μg/minute

26 (APACHE II)

24

>70

 

N+AV

5

53

DB

0.04 U/minute

 

27 (APACHE II)

24

 

Lauzier and colleagues [14]

N

10

58

RCT OL

Septic shock

28.1 μg/minute

23.5 (APACHE II)

48

>70

 

N+AV

13

51

 

(<12 hours of shock)

0.09 U/minute

22. (APACHE II)

48

 

Total

C

482

62.23 ± 5.70

-

-

38.72 ± 40.14

-

24 (4 to 48)

 
 

AV

472

59.60 ± 7.68

  

0.05 ± 0.02

 

36 (24 to 48)

-

 

TP

44

66.33 ± 0.57

  

59.03 ± 47.59

 

6 (4 to 48)

 
  1. Data presented as mean ± standard deviation or median (interquartile range). AV, arginine vasopressin; C, control; D, drug that the patients were already receiving at baseline; DB, double-blind; LVAD, left ventricular assist device; MAP, mean arterial pressure; N, norepinephrine; OL, open-label; P, placebo; PS, post-cardiotomy shock; RCT, randomized controlled trial; TP, terlipressin.