Drug | Dose | Comments |
---|---|---|
Artemether/lumefantrin | 80 mg arthemeter/480 mg lumefantrin once daily for 3 days | Well tolerated, faster parasite clearance, but longer fever resolution time |
Atovaquone/proguanil | 1000 mg atovaquone/400 mg proguanil at 0, 8, 24, 36, 48 and 60 hours | Well tolerated, more effective than mefloquine in treatment of multidrug-resistant falciparum malaria |
Mefloquine | 15 mg/kg (750 mg) base at 0 hours, followed by10 mg/kg (500 mg) base at 6–8 hours, and (if >60 kg) followed by 5 mg/kg (250 mg) at 16 hours | Contraindicated in persons with seizure or psychiatric disorders, or with cardiac conduction abnormalities |
Quinine (sulfate salt) | 10 mg salt/kg (600–650 mg) every 8 hours to complete7 days of treatment (total duration) | Side effects include cinchonism and pruritus |