Skip to main content

Table 1 Comparison of epidemiologic studies of severe sepsis

From: Severe sepsis epidemiology: sampling, selection, and society

    Methods Results for severe sepsis in the ICU
Reference Year Region Design Case identification Time frame Sampling frame No. of patients screened No. of cases identified Age (years; mean) Sex (% male) % of ICU ads Pop. incid. Hospital mortality (%)
[22] 1995 Italy Prospective Consensus criteria April 1993 – March 1994 First 3 cases each month in 99 ICUs in northern Italy 1101 128 NA NA 11.6 NA 52.2a
[8] 1995 France Prospective Consensus criteria January – February 1993 All cases in 170 medical ICUs 11,828 742 61.4 63 6.3 NA 59
[23] 1995 USA Prospective Consensus criteria August 1992 – April 1993 All cases in 3 ICUs and 3 floors in one hospital 3708b 467 55.1b 60b 12.6b NA 20b
[9] 1997 USA Prospective Consensus criteria January 1993 – April 1994 All ICU patients and all floor patients with blood cultures at 8 hospitals 9763 990 59b(median) 56a 10.1 NA 34b(28-day)
[12] 2001 USA Retrospective ICD-9-CM codes representing Consensus criteria 1995 All cases at all hospitals (n = 936) in 7 US states 880,473 98,613 63.8b 49.6b 11.2 1.53/1000 34.1
[14] 2003 UK Retrospective Consensus criteria December 1995 – February 2000 All cases on day 1 in 91 ICUs in national registry 56,673 15,362 65 (median) 54.3 27.1 0.51/1000 47.3
[24] 2003 USA Retrospective Consensus criteria 1998–1999 All cases on day 1 in 50 ICUs in Project IMPACT 21,480 2434 63.6 NA 11.3 NA 36.3
[25] 2003 Europe, Canada, Israel Prospective Consensus criteria May 1997 – May 1998 All cases in 28 ICUs 14,364 2124 NA NA 14.8 NA 19.6–49.3 in subgroups
[13] 2003 USA Retrospective ICD-9-CM code for septicemia only 1979–2000 NHDS, a 1% subset of all US hospital admissions 750 Mb 10.3 Mb 57.4–60.8b (1979–2000) 49.6–46.8b (1979–2000) NA NA 27.8–17.9b
[10] 2004 France Prospective Consensus criteria 2 weeks in November – December 2001 All cases in 206 ICUs 3738 546 65 (median) 66.9 14.6 NA 41.9 at 2 2 months
[11] 2004 Australia/NZ Prospective Consensus criteria May – August 1999 All cases in 23 ICUs 5878 691 60.7 56.9 11.8 0.77/1000 37.5
[7] 2004 Netherlands Prospective Consensus criteria 24 hours in December 2001 All cases in 47 ICUs 455 134 64 63 11 0.54/1000 NA
[6] 2004 Norway Retrospective ICD-10-CM codes representing Consensus criteria 1999 All cases in all Norwegian hospitals NA   57.9 NA NA 0.47/1000 27
[5] 2004 Brazil Prospective Consensus criteria 8 months in May 2001 – January 2002 5 ICUs 1383 241 66.2 median, all septic patients NA 17.4 NA 46.9
  1. aMortality rate was reported only for patients admitted with severe sepsis to the intensive care unit (ICU) but not for those who developed severe sepsis later. bResults are for all patients (both ICU and non-ICU) with severe sepsis in the study. ads, admissions; Pop. incid., population incodence; ICD-9-CM, International Classification of Diseases, 9th Revision, Clinical Modification; Project IMPACT, A proprietary dataset of Cerner Corporation, which contains organisational, patient-care and outcome data for over 100 ICUs in US and Latin America; NHDS, US National Hospital Discharge Survey.