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The cardiopulmonary bypass supported high-risk PTCA (CPB-PTCA): a useful model for the study of CPB-dependent systemic inflammatory response syndrome (SIRS)?

The mechanisms underlying myocardial depression following open heart surgery with extracorporeal circulation is still a matter of debate. One important trigger mechanism responsible for myocardial depression seems to be related to the release of cytokines during the systemic inflammatory response. Aim of the present study was to investigate whether CPB supported PTCA might be a useful model for the differentiation of surgery-dependent and CPB-SIRS-induced myocardial depression.

Methods

PTCA supported angioplasty with CPB; transesophageal echocardiography; wall motion score (WMS); plasma levels of cytokines and parameters as shown in the table. Seven patients, mean age 61.3 years, ejection fraction, 17–64%: five patients with three-vessel-CAD; two patients with two-vessel-CAD: four patients with CABG. (I) Before CPB: (II) beginning CPB: (III) immediately before PTCA; (IV) end CPB.

Results

See table.

Summary

CPB-PTCA helps to discriminate between surgery-induced and CBP-dependent systemic inflammatory response syndrome.

Table 1 Table 1
Table 2 Table 2

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Prondzinsky, R., Witthaut, R., Stabenow, I. et al. The cardiopulmonary bypass supported high-risk PTCA (CPB-PTCA): a useful model for the study of CPB-dependent systemic inflammatory response syndrome (SIRS)?. Crit Care 1, P033 (1997). https://0-doi-org.brum.beds.ac.uk/10.1186/cc39

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Keywords

  • Public Health
  • Inflammatory Response
  • Plasma Level
  • Ejection Fraction
  • Emergency Medicine