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sTREM-1 is not suitable to discriminate survivors and nonsurvivors in surgical patients with severe sepsis or septic shock
Critical Care volume 11, Article number: P47 (2007)
To evaluate in septic patients the plasma levels of sTREM-1, a soluble form of TREM-1, which seems to play an important role in inflammatory diseases, and to determine whether plasma sTREM-1 could be used as a diagnostic and prognostic marker in sepsis in the surgical ICU.
An observational clinical study.
The surgical ICU of the University Hospital of Heidelberg, Germany.
Patients admitted to the ICU over a 6-month period with clinical evidence of severe sepsis or septic shock.
Measurements and results
Sixty-six intensive care patients were enrolled in the study within the first 24 hours after the onset of severe sepsis or septic shock. Twenty-one healthy individuals served as controls. At day 0, day 1 and day 3 after diagnosis of severe sepsis or septic shock, plasma sTREM-1 was measured by ELISA. Plasma sTREM-1 concentrations of healthy controls did not differ from patients with severe sepsis or septic shock at day 0 (42.8 ± 44.9 pg/ml vs 40.8 ± 45.5 pg/ml, not significant), day 1 (42.8 ± 44.9 pg/ml vs 48.6 ± 57.2 pg/ml, not significant) nor at day 3 (42.8 ± 44.9 pg/ml vs 51.9 ± 52.8 pg/ml, not significant). Survivors were defined as patients surviving to at least day 28. There were no differences of plasma sTREM-1 between survivors and nonsurvivors at day 0, day 1 and day 3 (34.8 ± 44 52.4 pg/ml vs 49.5 ± 35.9 pg/ml, 42.6 ± 61.1 pg/ml vs 59.6 ± 47.1 pg/ml, and 47.9 ± 60.2 pg/ml vs 58.2 ± 37.1 pg/ml, not significant).
In this study including surgical patients with severe sepsis or septic shock, plasma sTREM-1 is not elevated compared with healthy controls. Furthermore, the measurement of plasma sTREM-1 did not allow one to differ between survivors and nonsurvivors. The suggested role of sTREM-1 as a diagnostic and prognostic marker in sepsis was not confirmed in this study.
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Bopp, C., Hofer, S., Kienle, P. et al. sTREM-1 is not suitable to discriminate survivors and nonsurvivors in surgical patients with severe sepsis or septic shock. Crit Care 11, P47 (2007). https://0-doi-org.brum.beds.ac.uk/10.1186/cc5207
- Plasma Level
- Care Patient
- Septic Shock
- Healthy Individual
- Emergency Medicine