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CeVOX for continuous central venous oxygenation measurement in patients undergoing off-pump coronary artery bypass grafting

Objective

The aim of this study was to compare central venous O2 saturation (ScvO2) [1] measured continuously by the CeVOX (Pulsion Medical System, Munich, Germany) device (CScvO2) with ScvO2 determined by blood gas co-oximetry (BScvO2).

Methods

Twenty-five patients undergoing elective off-pump coronary artery bypass grafting were studied during operation (OP) and during their ICU stay (ICU). OP/ICU measurement started after in vivo calibration of CeVOX. BScvO2 and CScvO2 readings were recorded at intervals of 30 minutes during OP and 120 minutes during ICU. Bland–Altman analysis and Pearson correlation was performed for overall OP, overall ICU, consecutive measurements during OP ≤ 1 hour, 1–2 hours and 2–3 hours after initial calibration (OP1–OP3, respectively) as well as during ICU ≤ 4 hours, 4–8 hours, 8–12 hours and 12–16 hours after recalibration (ICU1–ICU4, respectively).

Results

Five hundred and nine matched sets of data were obtained; the BScvO2/CScvO2 range was 36–98.9%/46.5–99.0%, respectively. Overall mean bias ± 2SD was -1.2 ± 13.8% for CScvO2–BScvO2 during OP and -2.6 ± 16.2% during ICU. The correlation coefficient (r2) for CScvO2 vs BScvO2 was 0.614 (OP) and 0.174 (ICU). Statistics for OP1–OP3 were comparable, whereas mean bias ± 2SD increased and r2 decreased during ICU1–ICU4 (Table 1).

Table 1 Table 1

Conclusion

The results indicate that ScvO2 can be reliably assessed by CeVOX. In order to maintain accurate measurements, scheduled re-calibrations at intervals <12 hours are mandatory.

References

  1. 1.

    Respiration. 2001, 685: 279-285.

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Rist, A., Schneider, S., Fodor, P. et al. CeVOX for continuous central venous oxygenation measurement in patients undergoing off-pump coronary artery bypass grafting. Crit Care 11, P302 (2007). https://0-doi-org.brum.beds.ac.uk/10.1186/cc5462

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Keywords

  • Public Health
  • Pearson Correlation
  • Emergency Medicine
  • Coronary Artery Bypass Grafting
  • Medical System