Effects of methylene blue on gas exchange and myocardial function in refractory septic shock with acute lung injury

Table

	Baseline	30 min	60 min	90 min	120 min	180 min	P
PaO₂ mmHg	85 ± 8	82 ± 7	83 ± 8	80 ± 8	78 ± 8	77 ± 7	NS
SaO₂ %	94 ± 2	95 ± 1	94 ± 1	94 ± 1	93 ± 2	94 ± 2	NS
PaO₂/FiO₂	184 ± 35	1 79 ± 30	176 ± 30	168 ± 27	169 ± 32	171 ± 33	NS
PA-aO₂	255 ± 88	255 ± 86	255 ± 86	255 ± 85	257 ± 85	277 ± 100	NS
Qs/Qt %	15 ± 5	17 ± 2	19 ± 2	22 ± 3	21 ± 4	25 ± 5	NS
ICI/min/m²	4.6 ± 0.5	4.5 ± 0.4	4.5 ± 0.4	4.6 ± 0.5	4.5 ± 0.5	4.4 ± 0.5	NS
IDO₂ ml/min/m²	581 ± 85	556 ± 62	553 ± 65	555 ± 63	536 ± 62	537 ± 60	NS
IVO₂ ml/min/m²	175 ± 30	143 ± 26	132 ± 22	128 ± 25	160 ± 38	144 ± 36	NS
O₂ extraction %	31 ± 5	27 ± 5	25 ± 4	23 ± 4	31 ± 7	28 ± 7	NS

No important differences were observed on gas exchange parameters and myocardial function.