Figure 1From: Pharmacodynamic optimization of β-lactams in the patient care settingIn vivo potency as a pharmacodynamic parameter for antibiotic therapy. Maintaining antibiotic concentrations above the minimum inhibitory concentration (MIC) is necessary to achieve in vivo potency and is dependent on the pharmacokinetics of the drug. AUC, area under the concentration-time curve; Cmax, maximum plasma concentration; T > MIC, time spent above the MIC.Back to article page