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Table 1 Vasopressin and copeptin levels in humans

From: Bench-to-bedside review: Vasopressin in the management of septic shock

Study

Condition

Vasopressin (AVP) levels

Provasopressin

Copeptin levels

Landry and colleagues [ 48 ]

Septic shock

3.1 pg/ml

  
 

Cardiogenic shock

22.7 pg/ml

  

Lin and colleagues [61]

Septic shock

3.6 pg/ml

  
 

Sepsis

10.6 pg/ml

  
 

Severe sepsis

21.8 pg/ml

  

Jochberger and colleagues [59]

Sepsis

11.9 pg/ml

  

Morgenthaler and colleagues [57]

Critically ill (no sepsis)

  

27 pM

 

Sepsis

  

50 pM

 

Severe sepsis

  

74 pM

 

Septic shock

  

171 pM

Lodha and colleagues [64]

Pediatric septic shock

116 pg/ml

  
 

Pediatric severe sepsis

106 pg/ml

  
 

Multiple trauma

44.3 pM

  

Russell and colleagues [52]

Septic shock

3.2 pM

  
 

Septic shock plus vasopressin infusion (0.03 U/minute) at 6 hours

74 pM

  
 

Septic shock plus vasopressin infusion (0.03 U/minute) at 24 hours

98 pM

  

Jochberger and colleagues [53]

Infection

3.2 pM*

 

25 pM*

 

Severe sepsis

6.5 pM*

 

60 pM*

 

Septic shock

6.4 pM*

 

70 pM*

Sharshar and colleagues[138]

Septic shock

1.6, 1.8, 16 pg/ml

  
  

Low neurophypophyseal T1 (AVP)

  
 

Neurohypophyseal levels of AVP

   

Sharshar and colleagues [139]

Septic shock

X

  

Le Clerc and colleagues [140]

Pediatric meningococcal shock

X

  

Kruger and colleagues [141]

Community-acquired pneumonia

   
 

Antibiotic pretreatment

  

12.8 pmol/l

 

Community-acquired pneumonia

   
 

No antibiotic pretreatment

  

20. 8 pmol/l

de Kruif and colleagues [142]

Pre Escherichia coli endotoxin in humans

 

12.5 pmol/l

 
 

Peak E. coli endotoxin in humans

 

18.0 pmol/l

 
 

Prednisone 10 mg pretreatment. Peak E. coli endotoxin in humans

 

10.6 pmol/l

 
 

Prednisone 30 mg pretreatment. Peak E. coli endotoxin in humans

 

6.1pmol/l

 
  1. *Estimated from the figures and text of Jochberger and colleagues [53]. Studies of septic shock are in bold for comparison.