From: Clinical neurophysiological assessment of sepsis-associated brain dysfunction: a systematic review
 | Ref | Type of evoked potential | Alterations in the evoked potential | Rate (%) or findings | Other findings |
---|---|---|---|---|---|
Case–control study (patients with systemic infection versus controls) | |||||
 | 16 | VEP | VEP N1-P1 | no difference |  |
Case series of patients with sepsis | |||||
 | 17 | SSEP, including long-latency responses | N9, N20 and N70 peak latency; N13–N20 and N20–N70 peak-peak latency | Prolonged in 57%, 47%, 94%, 34% and 84% of patients, respectively | SSEP peak latencies correlated with the APACHE III score and were the same in sedated and non-sedated patients. |
 | 22 | AEP | I-V interwave latency | Prolonged in 4/6 (67%) |  |
Case series or case–control study that included patients with and without sepsis | |||||
 | 29 | AEP | 15% decrease of the AAI | 80% in sepsis patients | The median AAI of patients with SAE, 58 (range of 40 to 70) whereas it in ones without, 70 (55 to 90). |
 | 25 | SSEP, including long-latency responses | N9, N20 and N70 peak latency; N13–N20 and N20–N70 peak-peak latency | Prolonged in patients with sepsis compared to controls | The delay of N70 peak latencies correlated with the APACHE III score. Peak latencies were not different in sedated and non-sedated patients. |