Incidence and outcome of inappropriate in-hospital empiric antibiotics for severe infection: a systematic review and meta-analysis

Table 4 Overview of studies evaluating the mortality rate at 28 and 60 days and 12 weeks

Reference	Time of mortality assessment	AAT mortality rate	IAAT mortality rate	Significant differences
Luna et al., 2006 [34]	28 days	29.17	63.46	0.007
Chen et al., 2013 [55]	28 days	9.09	38.04	0.001
Tseng et al., 2012 [51]	60 days	28.17	55.43	0.023
Kim et al., 2006 [8]	12 weeks	28.10	38.46	NS

AAT, appropriate antibiotic therapy; IAAT, inappropriate antibiotic therapy; NS, not significant.

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