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Table 3 Adjusted Cox proportional hazards models predicting 1-year post-discharge mortality

From: The impact of post-operative sepsis on mortality after hospital discharge among elective surgical patients: a population-based cohort study

Characteristics

Non-sepsis (n = 142,646)

Sepsis (n = 1857)

Mortality, %

HR (95% CI)

Mortality, %

HR (95% CI)

Year of admission†

 2007

4.1

1.00

16.7

1.00

 2008

4.1

1.03 (0.95–1.12)

10.9

0.70 (0.43–1.14)

 2009

3.9

1.03 (0.94–1.12)

11.8

0.76 (0.48–1.21)

 2010

3.7

1.05 (0.92–1.19)

16.1

1.04 (0.76–1.43)

 2011

3.7

1.05 (0.96–1.15)

14

0.88 (0.60–1.31)

 2012

3.5

0.98 (0.89–1.09)

11.8

0.78 (0.48–1.28)

Age groups

 ≥18 years to <35 years

0.5

1.00

6.6

1.00

 ≥35 years to <55 years

0.9

1.99** (1.35–2.93)

7.5

1.10 (0.40–3.04)

 ≥55 years to <75 years

2.1

5.46** (3.77–7.92)

10.8

1.60 (0.76–3.38)

 ≥75 years

9.2

20.0** (13.5–29.6)

22.1

3.50** (1.56–7.87)

Sex

 Male

4.3

1.00

13.4

1.00

 Female

3.4

0.76** (0.71–0.82)

13.7

1.05 (0.81–1.37)

Country of birth

 Australia and New Zealand

4.1

1.00

13.9

1.00

 United Kingdom, United States and Canada

4.4

0.96 (0.88–1.05)

11.7

0.66 (0.36–1.19)

 Non-English-speaking Europe

4.1

0.83** (0.74–0.93)

17.3

0.97 (0.69–1.36)

 North Africa

1.5

0.50** (0.44–0.58)

7.7

0.52 (0.18–1.53)

 Asia

1.9

0.68** (0.54–0.85)

10.8

0.80 (0.37–1.72)

 Others

1.7

0.66** (0.53–0.83)

6.5

0.47 (0.18–1.21)

 Unknown

5.6

1.02 (0.81–1.28)

17.2

1.45 (0.76–2.78)

Marital status

 Married

2.9

1.00

12.4

1.00

 Single

4.8

1.37** (1.28–1.46)

14.9

1.10 (0.89–1.36)

 Unknown

6.4

1.67** (1.37–2.03)

12.8

0.93 (0.39–2.24)

Severity of illness/co-morbidity

 Normal

2.5

1.00

9.2

1.00

 Moderate

7.5

2.04** (1.88–2.21)

9.9

0.96 (0.61–1.50)

 Severe

10.1

2.34** (2.01–2.72)

20.2

2.05** (1.45–2.89)

 Very severe

15.5

3.34** (2.99–3.72)

24.6

2.17** (1.49–3.17)

SEIFA quartiles

 First quartile (most disadvantaged)

4.0

1.00

14.9

1.00

 Second quartile

3.7

0.93 (0.85–1.00)

13.2

0.91 (0.65–1.26)

 Third quartile

3.5

0.94 (0.83–1.06)

11.8

0.71* (0.52–0.97)

 Fourth quartile (most advantaged)

4.3

0.99 (0.80–1.23)

13.1

0.68 (0.35–1.32)

 Unknown

2.4

0.64* (0.41–1.00)

20.8

1.59 (0.90–2.84)

Local health district of facility

 Metropolitan

3.7

1.00

13.8

1.00

 Rural and regional NSW

4.3

1.06 (0.88–1.27)

12.6

0.81 (0.60–1.10)

 Others

3.1

0.72** (0.64–0.81)

12.9

1.08 (0.70–1.67)

Peer hospital group

 Principal referral group

3.9

1.00

12.4

1.00

 Ungrouped acute

2.2

0.59** (0.44–0.80)

0

–

 Major metropolitan and non-metropolitan

4

1.20 (1.00–1.45)

17.1

1.53* (1.10–2.11)

 District groups 1 and 2

2.7

1.10 (0.85–1.44)

12.2

1.04 (0.40–2.73)

Major surgical procedure

 CABG

2.0

1.00

7.0

1.00

 Abdominal surgery

2.8

1.91** (1.50–2.43)

8.3

1.25 (0.61–2.56)

 EVAR

7.3

2.40** (1.92–3.00)

25.0

3.79** (1.39–10.3)

 Total hip replacement

1.5

0.80 (0.62–1.03)

11.1

1.51 (0.47–4.78)

 Total knee replacement

0.8

0.46** (0.36–0.59)

5.3

0.68 (0.19–2.42)

 Other

6.1

3.13** (2.50–3.91)

19.0

2.69** (1.38–5.22)

Length of stay

 

1.01** (1.01–1.01)

 

1.00** (1.00–1.01)

  1. Abbreviations: SEIFA Socio-Economic Indexes for Areas, CABG Coronary artery bypass graft, EVAR Endovascular aneurysm repair, NSW New South Wales
  2. † P value for trend year; P < 0.001 for non-sepsis group; P = 0.588 for sepsis group
  3. *P ≤ 0.05
  4. **P ≤ 0.01