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Table 2 Characteristics of the patients with and without hyperfibrinolysis in each group

From: Hyperfibrinolysis in severe isolated traumatic brain injury may occur without tissue hypoperfusion: a retrospective observational multicentre study

 

TBI

P value

Non-TBI

P value

Hyperfibrinolysis (-)

n = 77

Hyperfibrinolysis (+)

n = 34

Hyperfibrinolysis (-)

n = 80

Hyperfibrinolysis (+)

n = 46

Age, years

61 (41–72)

70 (51–83)

0.028

45 (36–62)

43 (26–70)

0.895

Male, n (%)

60 (78)

23 (68)

0.251

61 (76)

25 (54)

0.001

ISS

17 (16–26)

25 (25–26)

0.011

20 (17–25)

27 (18–34)

0.003

Revised trauma score

7.10 (6.17–7.84)

5.50 (4.09–7.84)

<0.001

7.84 (7.55–7.84)

7.55 (6.61–7.84)

0.022

Heart rate, per min

85 (75–93)

84 (65–93)

0.467

85 (71–98)

96 (85–111)

0.001

Systolic BP, mmHg

144 (126–169)

170 (138–193)

0.004

122 (103–140)

104 (87–128)

0.016

Respiratory rate, per min

19 (18–23)

20 (16–25)

0.774

22 (18–25)

24 (20–30)

0.036

Body temperature, °C

36.2 (35.8–36.7)

36.2 (35.6–36.8)

0.708

36.5 (35.8–36.9)

36.3 (35.7–36.6)

0.210

Glasgow coma scale score

13 (9–14)

6 (3–13)

<0.001

14 (14–15)

14 (12–15)

0.017

Time from the accident to sample collection

 0–30 min, n (%)

21 (28)

12 (35)

0.469

17 (22)

12 (27)

0.641

 31–60 min, n (%)

38 (51)

18 (53)

43 (54)

21 (48)

 61–90 min, n (%)

5 (7)

2 (6)

13 (17)

5 (11)

 91–120 min, n (%)

7 (9)

0 (0)

1 (1)

1 (2)

 Over 120 min, n (%)

4 (5)

2 (6)

5 (6)

5 (11)

 Unknown, n (%)

2 (3)

0 (0)

1 (1)

2 (4)

Arterial blood gas analyses

 pH

7.39 (7.35–7.43)

7.39 (7.37–7.42)

0.824

7.38 (7.34–7.43)

7.36 (7.30–7.40)

0.922

 Base deficit, mmol/L

1.1 (-0.4–2.9)

1.3 (-0.2–3.4)

0.707

1.7 (0.1–3.9)

2.4 (0.6–5.9)

0.676

 Lactate, mmol/L

2.40 (1.40–3.20)

2.44 (1.70–2.89)

0.738

2.30 (1.50–3.26)

2.90 (2.00–5.77)

0.454

Laboratory parameters

 White blood cells, × 109/L

8.7 (6.9–12.3)

11.2 (8.9–13.5)

0.013

11.1 (8.9–14.5)

13.7 (10.2–17.9)

0.009

 Haemoglobin, g/dL

14.0 (12.8–14.9)

13.1 (11.8–14.3)

0.075

13.9 (12.0–14.8)

12.2 (10.9–13.1)

<0.001

 Platelet count, × 109/L

19.1 (15.6–24.1)

17.0 (14.6–21.2)

0.170

23.2 (18.7–26.6)

20.2 (17.0–26.0)

0.079

 AST, U/L

29 (24–37)

40 (29-49)

0.022

63 (33–143)

109 (64–196)

0.004

 ALT, U/L

24 (17–34)

27 (17–34)

0.813

44 (24–81)

73 (40–116)

0.011

 LDH, U/L

249 (208–301)

312 (262–377)

0.001

378 (275–518)

677 (523–1064)

<0.001

 CK, U/L

144 (95–232)

175 (115–300)

0.183

289 (183–442)

455 (258–749)

0.001

 PT-INR

1.00 (0.96–1.05)

1.10 (0.97–1.17)

0.005

1.02 (0.96–1.07)

1.12 (1.06–1.20)

<0.001

 APTT, sec

24.1 (22.5–26.2)

29.8 (25.9-34.1)

<0.001

24.9 (23.1–27.1)

28.1 (24.8–31.9)

<0.001

 Fibrinogen, mg/dL

260 (219–299)

207 (149–269)

0.004

248 (206–293)

215 (177–264)

0.014

 D-dimer, μg/mL

10.5 (5.8–23.5)

93.2 (52.6–129.3)

<0.001

12.2 (5.8–23.0)

65.0 (54.6–100.0)

<0.001

  1. ISS injury severity score, BP blood pressure, AST aspartate aminotransferase, ALT alanine aminotransferase, LDH lactate dehydrogenase, CK creatine kinase, PT-INR prothrombin time–international normalized ratio, APTT activated partial thromboplastin time, TBI traumatic brain injury