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Table 3 Area under the ROC curve of plasma biomarkers for distinguishing between iARDS and dARDS

From: Biomarker profiles of coagulopathy and alveolar epithelial injury in acute respiratory distress syndrome with idiopathic/immune-related disease or common direct risk factors

Biomarkers

AUC

95% CI

Coagulation

 Platelet count

0.77

0.65–0.86

 Immature platelet fraction

0.69

0.54–0.81

 PT-INR

0.61

0.49–0.73

 FDP

0.51

0.38–0.63

 TAT

0.72

0.59–0.82

 PIC

0.69

0.56–0.80

 PAI-1

0.89

0.74–0.96

 Protein C

0.86

0.76–0.93

Infection/inflammation

 PCT

0.89

0.79–0.96

 CRP

0.65

0.52–0.76

Alveolar epithelial injury

 SP-D

0.88

0.77–0.94

 KL-6

0.90

0.79–0.95

  1. AUC area under the receiver characteristics curve, CI confidence interval, PT-INR prothrombin time–international normalized ratio, FDP fibrin degradation products, TAT thrombin–antithrombin complex, PIC plasmin–α2-plasmin inhibitor complex, PAI-1 plasminogen activator inhibitor-1, PCT procalcitonin, CRP C-reactive protein, SP surfactant protein
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Critical Care

ISSN: 1364-8535