Capillary refill time variation induced by passive leg raising predicts capillary refill time response to volume expansion

Table 3 Diagnostic performances to predict CRT and cardiac index responsiveness

	Index test	AUC [95% CI]	Best threshold	Specificity	Sensitivity	PPV	NPV	Youden index
Peripheral perfusion response (decrease of 25% of CRT after VE)	ΔCRT-PLR	0.94 [0.87–1.0]	− 27% [− 30, − 18]	1.00 [0.74–1.00]	0.87 [0.73–1.0]	1.0 [0.72–1.0]	0.91 [0.79–1.0]	0.87
	PCO₂gap	0.79 [0.61–0.93]	1.2 kPa [0.9–1.6]	0.73 [0.53–0.93]	0.79 [0.57–1.00]	0.72 [0.58–0.92]	0.79 [0.62–1.00]	0.52
	Baseline CRT	0.73 [0.54–0.90]	2.7 s [2.6–4.1]	0.74 [0.47–1.0]	0.80 [0.47–1.00]	0.69 [0.54–1.00]	0.67 [0.8–1.00]	0.49
Cardiac index response (increase of 15% of CI)	ΔCI-PLR	0.95 [0.86–1.00]	9.0% [8.7–13.7]	0.90 [0.71–1.00]	1.00 [0.77–1.00]	0.85 [0.68–1.00]	1.00 [0.86–1]	0.90

ROC_AUC area under the receiving operating characteristic curves, CRT capillary refill time, VE volume expansion, ΔCRT-PLR variation of CRT induced by passive leg raising (PLR), ΔCI-PLR variation of cardiac index induced by PLR, NPV negative predictive value, PPV positive predictive value

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