Plasma glutamine status at intensive care unit admission: an independent risk factor for mortality in critical illness

Table 3 Logistic regression and multiple logistic regression in panels A and B for all patients, and in panels C and D with the postoperative liver transplant patients excluded

Parameter	OR (95% confidence interval)	p value
(A) Univariate logistic regression of six-months mortality rate in 269 ICU patients
p-Gln ≥ 930 µmol/L	1.97 (1.30–2.99)	0.002
Age [per year]	1.038 (1.014–1.063)	< 0.001
SOFA score [per point]	1.18 (1.09–1.27)	< 0.001
SAPS score [per point]	1.042 (1.022–1.063)	< 0.001
All amino acids [per mmol/L]	1.12 (0.96–1.31)	0.059

Parameter	Beta	OR (95% confidence interval)	p value
(B) Multivariate logistic regression of six-months mortality rate in 269 ICU patients
Intercept	− 5.11
p-Gln ≥ 930 µmol/L	0.779	2.18 (1.26–3.76)	0.006
Age [per year]	0.039	1.040 (1.012–1.069)	0.003
SOFA score [per point]	0.114	1.12 (1.02–1.23)	0.015
SAPS score [per point]	0. 020	1.020 (0.997–1.044)	0.085
All Amino Acids [per mmol/L]	0.006	1.006 (0.876–1.155)	0.932

Parameter	OR (95% confidence interval)	p value
(C) Univariate logistic regression of six-months mortality rate in 226 ICU patients
p-Gln ≥ 930 µmol/L	2.52 (1.54–4.13)	< 0.001
Age [per year]	1.033 (1.010–1.057)	0.002
SOFA score [per point]	1.17 (1.08–1.27)	< 0.001
SAPS score [per point]	1.031 (1.009–1.052)	0.004
All amino acids [per mmol/L]	1.23 (0.98–1.53)	0.015

Parameter	beta	OR (95% confidence interval)	p value
(D) Multivariate logistic regression for prediction of six-months mortality rate in 226 ICU patients
Intercept	− 3.74
p-Gln ≥ 930 µmol/L	1.14	3.12(1.61–6.06)	< 0.001
Age [per year]	0.046	1.047 (1.018–1.077)	< 0.001
SOFA score [per point]	0.160	1.17 (1.06–1.30)	0.001
SAPS score [per point]	− 0.0056	0.994 (0.968–1.021)	0.679
All amino acids [per mmol/L]	− 0.018	0.98 (0.83–1.16)	0.833

p-Gln, glutamine plasma concentration at admission; SOFA, Sequential Organ Failure Assessment; SAPS, Simplified Acute Physiology Score 3

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