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Table 1 A selection of studies evaluating associations between near infrared spectroscopy (NIRS) measured and derived variables with outcome, in intensive care unit (ICU)-treated out-of-hospital cardiac arrest

From: Monitoring and modifying brain oxygenation in patients at risk of hypoxic ischaemic brain injury after cardiac arrest

First author [ref]

Year

Design

Number of patients

Type of cardiac arrest

Outcome

Principal finding

Meex [14]

2013

Observational study

28

CA patients treated with TTM

Functional outcome by CPC at hospital discharge

Decrease in rSO2 during induction of TTM. Lower rSO2 levels in patients with poor outcome

Storm [15]

2014

Observational study

60

OHCA and IHCA

Functional outcome at discharge by CPC

Higher NIRS values in patients with good outcome. An rSO2 below 50% appeared associated with poor outcome

Ameloot [33]

2015

Observational study

51

All types of CA

Functional outcome at 180 days by CPC

Disturbed autoregulation more common in patients with chronic hypertension. Time below an autoregulation-derived optimal MAP was negatively associated with outcome

Pham [24]

2015

Observational study

23

OHCA

Functional outcome at 90 days by CPC

No difference in rSO2 in patients, by outcome. Suggestion of disturbed autoregulation in poor outcome patients

Bougle [20]

2016

Observational study

43

OHCA treated with TTM

Functional outcome by CPC on hospital discharge

Mean rSO2 was not different, when indexed by outcome, but the lowest measured was lower in poor outcome patients

Genbrugge [16]

2016

Observational study

107

OHCA

Functional outcome at 180 days by CPC

Slightly higher rSO2 in patients with good outcome. No reliable threshold value was identified

Saritas [21]

2018

Observational study

25

OHCA patients

Functional outcome by CPC on hospital discharge

No difference in rSO2, in patients with good and poor outcome

Jakkula [23]

2019

Post-hoc analysis of interventional data

120

VF arrests with a cardiac cause

Six-month functional outcome by CPC and brain injury assessed with NSE

No association between the mean, median, lowest or highest NIRS value during the first 36 h of ICU care with outcome or the level of NSE at 48 h

  1. CA cardiac arrest, CPC cerebral performance category, IHCA in-hospital cardiac arrest, MAP mean arterial pressure, NSE neuron specific enolase, OHCA out-of-hospital cardiac arrest, rSO2 regional cerebral oxygen saturation, TTM targeted temperature management, VF ventricular fibrillation