Fig. 2

Adjusted differences in biomarker concentrations between persistent and resolving hypoxemic respiratory failure, stratified by acute respiratory distress syndrome (± ARDS). Abbreviations: IL-6 = interleukin-6; IL-8 = interleukin-8; sTNFR-1 = soluble tumor necrosis factor receptor-1; sFas = soluble Fas; IL-17A = interleukin-17A; G-CSF = granulocyte colony-stimulating factor; Ang-2 = angiopoietin-2; Ang-1 = angiopoietin-1; sVCAM-1 = soluble vascular cell adhesion protein-1; n.a. = not applicable (not measured in specified cohort); ARDS = acute respiratory distress syndrome; HRF = hypoxemic respiratory failure. Fold differences reflect ratio of geometric mean concentrations among patients in each specified group, to patients with resolving hypoxemic respiratory failure without ARDS (resolving HRF/-ARDS). Fold differences are adjusted for age, sex, chronic respiratory disease, and modified acute physiology and chronic health evaluation (APACHE-III in discovery cohort and APACHE-II in validation cohort). ** P < 0.001 * P < 0.05