Table 1 Baseline characteristics

Baseline characteristics

n

83

Age (years)

53.0 [40.5/67.0]

Gender (m/f)

57/26 [68.7%/31.3%]

BMI (kg/m²)

27.1 [23.4/29.9]

ICU length of stay (days)

28.0 [20.0/42.0]

Time of first awakening (days after admission)

12.0 [9.0/20.0]

Survival (non-survivors/survivors)

14/69 [16.9%/83.1%]

Catastrophic event leading to ICU admission

ARDS

28 [33.7%]

Sepsis

20 [24.1%]

Trauma

19 [22.9%]

CNS

15 [18.1%]

Miscellaneous

1 [1.2%]

Illness severity at ICU admission

SOFA score

13 [10/15]

APACHE

23 [17/28]

SAPS2

52 [39/63]

Time interval between ICU admission and muscle biopsy

N

59

Biopsy day (days after admission)

16.0 [14.0/19.5]

RASS

-3.0 [-4.0/-1.0]

Percent of days with RASS > − 3

40.0 [22.3/64.6]

Noradrenalin (µg/kg*min)

0.05 [0.03/0.10]

Noradrenalin days (days noradrenalin was required to maintain blood pressure)

9.0 [5.0/12.0]

Percent of days with septic shock (%)

21.4 [8.6/43.6]

Intervention quantity

Net time patient received physiotherapy per day until muscle biopsy (minutes)^a

18.2 [13.3/21.7]

Net time patient received physiotherapy per day until ICU discharge (minutes)^a

20.0 [14.2/22.8]

Healthy controls—plasma

n

91

Age (years)

53.0 [42.0/66.5]

Gender (m/f)

51/40 [56.0%/44.0%]

Healthy controls—muscle biopsy specimen

n

11

Age (years)

58.0 [44.0/56.0]

Gender (m/f)

7/4 [63.6%/36.4%]