Skip to main content

Outcomes after extracorporeal life support for COVID-19 myocarditis: an analysis of the Extracorporeal Life Support Organization Registry

First described early in the pandemic, coronavirus disease 2019 (COVID-19)-associated fulminant myocarditis can present with arrhythmias and cardiogenic shock, but may be treatable with mechanical circulatory support, such as venoarterial (VA) extracorporeal life support (ECLS) [1]. To better characterize severe myocarditis during the COVID-19 pandemic, we analyzed adult patients with severe COVID-19 who received ECLS for cardiac, pulmonary, or combined failure using an international registry.

We calculated the rate of mechanical circulatory support use among patients receiving ECLS for COVID-19, describing patient characteristics and risk factors for mortality. We utilized the Extracorporeal Life Support Organization (ELSO) Registry and extracted data on patients ≥ 18 years old, diagnosed with COVID-19 from January 1, 2020, through March 31, 2021. Data released from ELSO are de-identified, do not meet the definition of Human Subjects Research, and therefore do not require repeat human subjects review.

Among 4792 patients receiving ECLS for COVID-19 (Table 1), 4.9% (234) were supported with VA-ECMO, and 88 patients (1.8%) had acute myocarditis during the study period. Among those with myocarditis, 35% were women (p = 0.092). COVID-19 patients receiving ECLS who were diagnosed with myocarditis (n = 88) were more likely to be managed with cardiac support versus pulmonary support (53% vs. 42%, p < 0.001). Among all patients supported for a cardiac indication, patients with myocarditis had less hypercarbia (PaCO2: 45 mmHg vs. 66 mmHg; p < 0.001), less hypoxemia (PaO2: 94 mmHg vs. 80 mmHg; p = 0.078), greater metabolic acidosis (serum bicarbonate 22 mEq/L vs. 28 mEq/L; p < 0.001), lower blood pressure (systolic: 101 mmHg vs. 119 mmHg; p < 0.001), and lower pulse pressure (43 mmHg vs. 55 mmHg; p < 0.001) compared with patients without myocarditis. Death percentages were similar between those with and without myocarditis.

Table 1 Differences in characteristics between COVID-19 patients on ECLS with and without myocarditis

We acknowledge limitations to this analysis. The Registry did not require myocardial biopsy to prove myocarditis, and hence, patients may have had myocarditis diagnosed as acutely decreased myocardial function on echocardiography accompanied by elevated cardiac enzymes and/or electrocardiographic changes. To account for potential overdiagnosis of myocarditis, we performed a sensitivity analysis excluding patients coded for acute myocardial infarction (AMI). The results were unchanged.

In summary, among patients with COVID-19 supported with ECLS, a diagnosis of myocarditis was uncommon (1.8%) and mortality was 51%. In context, mortality among ECLS patients in the ELSO Registry for COVID-19 was 37% early in the pandemic, and 52% later [2]. This is compared to 25–42% mortality for critically ill COVID-19 patients without ECLS [3]. Risk factors for death among patients with myocarditis receiving ECLS were increasing age and preexisting diabetes mellitus. These findings are consistent with previously identified mortality risk factors in non-ECLS patients with severe COVID-19 [3].

Our findings are important for a number of reasons. While within many high-income nations, high rates of vaccination have greatly reduced mortality, across the world vaccination rates remain only 60% and the pandemic is not over. Our results are the largest COVID-19 myocarditis case series using ECLS and may inform future outbreaks. Finally, we identified that risk factors for mortality among patients with myocarditis on ECLS are not different than among patients without myocarditis. In conclusion, within the largest international Registry of patients requiring ECLS circulatory support for COVID-19, mortality appears higher than for patients with COVID-19 without ECLS, but no different than those on ECLS with only acute respiratory failure.

Availability of data and materials

Data were analyzed under contract from ELSO and can be requested from ELSO directly.

Abbreviations

COVID-19:

Coronavirus disease 2019

ECLS:

Extracorporeal life support

ELSO:

Extracorporeal Life Support Organization

AMI:

Acute myocardial infarction

References

  1. Salamanca J, Díez-Villanueva P, Martínez P, Cecconi A, González B, de Marcos G, Reyes CS, Segovia J, Jiménez-Borreguero LJ, Alfonso F. COVID-19 “fulminant myocarditis” successfully treated with temporary mechanical circulatory support. JACC Cardiovasc Imaging. 2020;13(11):2457–9. https://0-doi-org.brum.beds.ac.uk/10.1016/j.jcmg.2020.05.003.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Barbaro RP, MacLaren G, Boonstra PS, Combes A, Agerstrand C, Annich G, Diaz R, Fan E, Hryniewicz K, Lorusso R, et al. Extracorporeal membrane oxygenation for COVID-19: evolving outcomes from the international extracorporeal life support organization registry. Lancet. 2021;398(10307):1230–8.

    CAS  Article  Google Scholar 

  3. Network C-IGobotR. The C-ICUI: clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study. Intensiv Care Med. 2021;47(1):60–73.

    Article  Google Scholar 

Download references

Acknowledgements

The authors would like to thank all ELSO Member Centers who diligently and with much effort collected and submitted high-quality data on patients with COVID-19 during the pandemic.

Funding

Dr. Tonna is supported by a Career Development Award from the National Institutes of Health (NIH)/National Heart, Lung, And Blood Institute (K23 HL141596). This study was also supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1TR002538 (formerly 5UL1TR001067-05, 8UL1TR000105 and UL1RR025764). Dr. Barbaro receives support from the NIH unrelated to this work (R01 HL153519). None of the funding sources were involved in the design or conduct of the study, collection, management, analysis or interpretation of the data, or preparation, review, or approval of the manuscript.

Author information

Authors and Affiliations

Authors

Contributions

JT, RB, GM, and DB designed the study; JT, CST, KH, RB, GM, and DB conducted the study; JT and CST contributed to data acquisition and analysis; JT was involved in drafting of the manuscript; and all authors revised the article for important intellectual content and had approved the final manuscript for publication. JT had full access to the study data and takes responsibility for the data integrity, accuracy, and integrity of the submission as a whole. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Joseph E. Tonna.

Ethics declarations

Ethics approval and consent to participate

This was an analysis of fully de-identified data, which is not human subjects research and therefore did not require Institutional Review Board approval.

Consent for publication

Not applicable.

Competing interests

Dr. Tonna is the Chair-elect of the Registry Committee of the Extracorporeal Life Support Organization (ELSO). Dr. Barbaro is the ELSO Registry Chair. Dr. MacLaren serves on the board of directors for ELSO. Dr. Brodie receives research support from ALung Technologies. He has been on the medical advisory boards for Abiomed, Xenios, Medtronic, Inspira, and Cellenkos. He is the President-elect of ELSO and the Chair of the Executive Committee of the International ECMO Network (ECMONet).

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Tonna, J.E., Tan, C.S., Hryniewicz, K. et al. Outcomes after extracorporeal life support for COVID-19 myocarditis: an analysis of the Extracorporeal Life Support Organization Registry. Crit Care 26, 235 (2022). https://0-doi-org.brum.beds.ac.uk/10.1186/s13054-022-04111-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://0-doi-org.brum.beds.ac.uk/10.1186/s13054-022-04111-z

Keywords

  • Cardiac failure
  • Respiratory failure
  • Acute respiratory distress syndrome
  • Myocardial inflammation