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  1. Healthcare systems are large contributors to global emissions, and intensive care units (ICUs) are a complex and resource-intensive component of these systems. Recent global movements in sustainability initiat...

    Authors: Faisal N. Masud, Farzan Sasangohar, Iqbal Ratnani, Sahar Fatima, Marco Antonio Hernandez, Teal Riley, Jason Fischer, Atiya Dhala, Megan E. Gooch, Konya Keeling-Johnson, Jukrin Moon and Jean-Louis Vincent
    Citation: Critical Care 2024 28:154
  2. Re-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to con...

    Authors: Tommaso Pettenuzzo, Annalisa Boscolo, Elisa Pistollato, Chiara Pretto, Tommaso Antonio Giacon, Sara Frasson, Francesco Maria Carbotti, Francesca Medici, Giovanni Pettenon, Giuliana Carofiglio, Marco Nardelli, Nicolas Cucci, Clara Letizia Tuccio, Veronica Gagliardi, Chiara Schiavolin, Caterina Simoni…
    Citation: Critical Care 2024 28:152
  3. Intensive care unit (ICU)-survivors have an increased risk of mortality after discharge compared to the general population. On ICU admission subphenotypes based on the plasma biomarker levels of interleukin-8,...

    Authors: Marleen A. Slim, Rombout B. E. van Amstel, Lieuwe D. J. Bos, Olaf L. Cremer, W. Joost Wiersinga, Tom van der Poll and Lonneke A. van Vught
    Citation: Critical Care 2024 28:151
  4. Prior assessments of critical care outcomes in patients with cirrhosis have shown conflicting results. We aimed to provide nationwide generalizable results of critical care outcomes in patients with decompensa...

    Authors: Spencer R. Goble, Abdellatif S. Ismail, Jose D. Debes and Thomas M. Leventhal
    Citation: Critical Care 2024 28:150
  5. Sepsis occurs in 12–27% of patients with haematological malignancy within a year of diagnosis. Sepsis mortality has improved in non-cancer patients in the last two decades, but longitudinal trends in patients ...

    Authors: Aleece MacPhail, Claire Dendle, Monica Slavin, Robert Weinkove, Michael Bailey, David Pilcher and Zoe McQuilten
    Citation: Critical Care 2024 28:148
  6. A systematic review and meta-analysis to evaluate the impact of extracorporeal carbon dioxide removal (ECCO2R) on gas exchange and respiratory settings in critically ill adults with respiratory failure.

    Authors: Alexandra-Maria Stommel, Harald Herkner, Calvin Lukas Kienbacher, Brigitte Wildner, Alexander Hermann and Thomas Staudinger
    Citation: Critical Care 2024 28:146
  7. Screening for hazardous alcohol use and performing brief interventions (BIs) are recommended to reduce alcohol-related negative health consequences. We aimed to compare the effectiveness (defined as an at leas...

    Authors: Eliisa Nissilä, Marja Hynninen, Ville Jalkanen, Anne Kuitunen, Minna Bäcklund, Outi Inkinen and Johanna Hästbacka
    Citation: Critical Care 2024 28:145
  8. Physical rehabilitation of critically ill patients is implemented to improve physical outcomes from an intensive care stay. However, before rehabilitation is implemented, a risk assessment is essential, based ...

    Authors: Huw R. Woodbridge, Christopher J. McCarthy, Mandy Jones, Matthew Willis, David B. Antcliffe, Caroline M. Alexander and Anthony C. Gordon
    Citation: Critical Care 2024 28:144
  9. To determine whether intermittent intravenous (IV) paracetamol as primary analgesic would significantly reduce morphine consumption in children aged 0–3 years after cardiac surgery with cardiopulmonary bypass.

    Authors: Gerdien Zeilmaker-Roest, Christine de Vries-Rink, Joost van Rosmalen, Monique van Dijk, Saskia N. de Wildt, Catherijne A. J. Knibbe, Erik Koomen, Nicolaas J. G. Jansen, Martin C. J. Kneyber, Sofie Maebe, Greet Van den Berghe, Renata Haghedooren, Dirk Vlasselaers, Ad J. J. C. Bogers, Dick Tibboel and Enno D. Wildschut
    Citation: Critical Care 2024 28:143

    The Matters Arising to this article has been published in Critical Care 2024 28:193

  10. End-expiratory lung volume (EELV) is reduced in mechanically ventilated patients, especially in pathologic conditions. The resulting heterogeneous distribution of ventilation increases the risk for ventilation...

    Authors: J. A. Sanchez Giralt, G. Tusman, M. Wallin, M. Hallback, A. Perez Lucendo, M. Sanchez Galindo, B. Abad Santamaria, E. Paz Calzada, P. Garcia Garcia, D. Rodriguez Huerta, A. Canabal Berlanga and Fernando Suarez-Sipmann
    Citation: Critical Care 2024 28:142

    The Correction to this article has been published in Critical Care 2024 28:200

  11. Clinicians currently monitor pressure and volume at the airway opening, assuming that these observations relate closely to stresses and strains at the micro level. Indeed, this assumption forms the basis of cu...

    Authors: John J. Marini, Patricia R. M. Rocco, Lauren T. Thornton and Philip S. Crooke
    Citation: Critical Care 2024 28:141
  12. This study aimed to validate apparent diffusion coefficient (ADC) values and thresholds to predict poor neurological outcomes in out-of-hospital cardiac arrest (OHCA) survivors by quantitatively analysing the ...

    Authors: Jung A Yoon, Changshin Kang, Jung Soo Park, Yeonho You, Jin Hong Min, Yong Nam In, Wonjoon Jeong, Hong Jun Ahn, Hye Seon Jeong, Yong Hwan Kim, Byung Kook Lee and Dongha Kim
    Citation: Critical Care 2024 28:138
  13. In acute respiratory distress syndrome (ARDS), respiratory drive often differs among patients with similar clinical characteristics. Readily observable factors like acid–base state, oxygenation, mechanics, and...

    Authors: Elias Baedorf-Kassis, Michael Murn, Amy L. Dzierba, Alexis L. Serra, Ivan Garcia, Emily Minus, Clarissa Padilla, Todd Sarge, Valerie M. Goodspeed, Michael A. Matthay, Michelle N. Gong, Deborah Cook, Stephen H. Loring, Daniel Talmor and Jeremy R. Beitler
    Citation: Critical Care 2024 28:136
  14. In this study, the concentrations of inflammatory cytokines were measured in the bronchial epithelial lining fluid (ELF) and plasma in patients with acute hypoxemic respiratory failure (AHRF) secondary to seve...

    Authors: Kazuki Sudo, Mao Kinoshita, Ken Kawaguchi, Kohsuke Kushimoto, Ryogo Yoshii, Keita Inoue, Masaki Yamasaki, Tasuku Matsuyama, Kunihiko Kooguchi, Yasuo Takashima, Masami Tanaka, Kazumichi Matsumoto, Kei Tashiro, Tohru Inaba, Bon Ohta and Teiji Sawa
    Citation: Critical Care 2024 28:134
  15. Acute respiratory distress syndrome (ARDS) is responsible for 400,000 deaths annually worldwide. Few improvements have been made despite five decades of research, partially because ARDS is a highly heterogeneo...

    Authors: Sébastien Imbert, Mathilde Revers, Raphaël Enaud, Arthur Orieux, Adrian Camino, Alexandre Massri, Laurent Villeneuve, Cédric Carrié, Laurent Petit, Alexandre Boyer, Patrick Berger, Didier Gruson, Laurence Delhaes and Renaud Prével
    Citation: Critical Care 2024 28:133

    The Matters Arising to this article has been published in Critical Care 2024 28:188

    The Matters Arising to this article has been published in Critical Care 2024 28:147

  16. Rapidly improving acute respiratory distress syndrome (RIARDS) is an increasingly appreciated subgroup of ARDS in which hypoxemia improves within 24 h after initiation of mechanical ventilation. Detailed clini...

    Authors: Patricia L. Valda Toro, Andrew Willmore, Nelson E. Wu, Kevin L. Delucchi, Alejandra Jauregui, Pratik Sinha, Kathleen D. Liu, Carolyn M. Hendrickson, Aartik Sarma, Lucile P. A. Neyton, Aleksandra Leligdowicz, Charles R. Langelier, Hanjing Zhuo, Chayse Jones, Kirsten N. Kangelaris, Antonio D. Gomez…
    Citation: Critical Care 2024 28:132
  17. Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring mechanical ventilation suffer from a high incidence of ventilator associated pneumonia (VAP), mainly relate...

    Authors: Keyvan Razazi, Charles-Edouard Luyt, Guillaume Voiriot, Anahita Rouzé, Marc Garnier, Alexis Ferré, Laurent Camous, Nicholas Heming, Nathanaël Lapidus, Anais Charles-Nelson and Armand Mekontso-Dessap
    Citation: Critical Care 2024 28:131
  18. Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARB) medications are widely prescribed. We sought to assess how pre-admission use of these medications might impact the respons...

    Authors: Daniel E. Leisman, Damian R. Handisides, Laurence W. Busse, Mark C. Chappell, Lakhmir S. Chawla, Michael R. Filbin, Marcia B. Goldberg, Kealy R. Ham, Ashish K. Khanna, Marlies Ostermann, Michael T. McCurdy, Christopher D. Adams, Tony N. Hodges and Rinaldo Bellomo
    Citation: Critical Care 2024 28:130
  19. Randomized data evaluating the impact of the extracorporeal cardiopulmonary resuscitation (ECPR) approach on long-term clinical outcomes in patients with refractory out-of-hospital cardiac arrest (OHCA) are la...

    Authors: Daniel Rob, Klaudia Farkasovska, Marketa Kreckova, Ondrej Smid, Petra Kavalkova, Jaromir Macoun, Michal Huptych, Petra Havrankova, Juraj Gallo, Jan Pudil, Milan Dusik, Stepan Havranek, Ales Linhart and Jan Belohlavek
    Citation: Critical Care 2024 28:125
  20. Extracorporeal Carbon Dioxide Removal (ECCO2R) is used in acute respiratory distress syndrome (ARDS) patients to facilitate lung-protective ventilatory strategies. Electrical Impedance Tomography (EIT) allows ind...

    Authors: Benjamin Pequignot, Alain Combes, Mickael Lescroart, Bruno Levy and Matthieu Koszutski
    Citation: Critical Care 2024 28:124
  21. To perform a systematic review with meta-analysis with the dual intent of assessing the impact of attaining aggressive vs. conservative beta-lactams PK/PD target on the clinical efficacy for treating Gram-nega...

    Authors: Milo Gatti, Pier Giorgio Cojutti and Federico Pea
    Citation: Critical Care 2024 28:123
  22. Authors: Amit Kansal, Jos M. Latour, Kay Choong See, Sumeet Rai, Maurizio Cecconi, Carl Britto, Andrew Conway Morris, Raymond Dominic Savio, Vinay M. Nadkarni, B. K. Rao and Rajesh Mishra
    Citation: Critical Care 2024 28:121

    The original article was published in Critical Care 2023 27:487

  23. Sepsis is associated with high morbidity and mortality, primarily due to systemic inflammation-induced tissue damage, resulting organ failure, and impaired recovery. Regulated extracellular matrix (ECM) turnov...

    Authors: YiWen Fan, Jill Moser, Matijs van Meurs, Dorien Kiers, Jannie Marie Bülow Sand, Diana Julie Leeming, Peter Pickkers, Janette K. Burgess, Matthijs Kox and Janesh Pillay
    Citation: Critical Care 2024 28:120
  24. There is a lack of information about the organisation and management of clinical research personnel in Europe and of their professional activity in intensive care. We therefore conducted a cross-sectional surv...

    Authors: Mireille Adda, Claire Dupuis, Gérald Gouby, Claude Dubray, Jean Reignier, Bertrand Souweine and Christian Dualé
    Citation: Critical Care 2024 28:119
  25. This study aimed to develop an automated method to measure the gray-white matter ratio (GWR) from brain computed tomography (CT) scans of patients with out-of-hospital cardiac arrest (OHCA) and assess its sign...

    Authors: Hsinhan Tsai, Chien-Yu Chi, Liang-Wei Wang, Yu-Jen Su, Ya-Fang Chen, Min-Shan Tsai, Chih-Hung Wang, Cheyu Hsu, Chien-Hua Huang and Weichung Wang
    Citation: Critical Care 2024 28:118
  26. Authors: Louis‑Marie Galerneau, Sebastien Bailly, Nicolas Terzi, Stephane Ruckly, Maite Garrouste‑Orgeas, Johanna Oziel, Vivien Hong Tuan Ha, Marc Gainnier, Shidasp Siami, Claire Dupuis, Jean‑Marie Forel, Anais Dartevel, Julien Dessajan, Christophe Adrie, Dany Goldgran‑Toledano, Virginie Laurent…
    Citation: Critical Care 2024 28:117

    The original article was published in Critical Care 2023 27:359

  27. The purpose was to evaluate glial fibrillary acidic protein (GFAP) and total-tau in plasma as predictors of poor neurological outcome after out-of-hospital (OHCA) and in-hospital cardiac arrest (IHCA), includi...

    Authors: Isabelle Arctaedius, Helena Levin, Bergthóra Thorgeirsdóttir, Marion Moseby-Knappe, Tobias Cronberg, Martin Annborn, Niklas Nielsen, Henrik Zetterberg, Kaj Blennow, Nicholas J. Ashton, Attila Frigyesi, Hans Friberg, Anna Lybeck and Niklas Mattsson-Carlgren
    Citation: Critical Care 2024 28:116
  28. Sepsis-induced myocardial injury is a serious complication of sepsis. QT prolongation is a proarrhythmic state which reflects myocardial injury in a group of heterogeneous disorders. However, the study on the ...

    Authors: Weizhuo Liu, Rongjiao Shao, Shen Zhang, Lei Jin, Rongchen Liu, Peidong Chen, Jintao Hu, Haocheng Ma, Bangwei Wu, Weiguo Liang, Xinping Luo, Jian Li, Weiming Chen, Nanqing Xiong and Bin He
    Citation: Critical Care 2024 28:115
  29. Anemia is a hallmark of critical illness, which is largely inflammatory driven. We hypothesized that the use of anti-inflammatory agents limits the development of anemia and reduces the need for red blood cell...

    Authors: Madelief Bolscher, Stephanie C. E. Koster, Matty Koopmans, Jelle L. G. Haitsma Mulier, Lennie P. G. Derde and Nicole P. Juffermans
    Citation: Critical Care 2024 28:114
  30. Perhaps nowhere else in the healthcare system than in the intensive care unit environment are the challenges to create useful models with direct time-critical clinical applications more relevant and the obstac...

    Authors: Michael R. Pinsky, Armando Bedoya, Azra Bihorac, Leo Celi, Matthew Churpek, Nicoleta J. Economou-Zavlanos, Paul Elbers, Suchi Saria, Vincent Liu, Patrick G. Lyons, Benjamin Shickel, Patrick Toral, David Tscholl and Gilles Clermont
    Citation: Critical Care 2024 28:113
  31. Approximately one in three survivors of critical illness suffers from intensive-care-unit-acquired weakness, which increases mortality and impairs quality of life. By counteracting immobilization, a known risk...

    Authors: Lucas Huebner, Angelika Warmbein, Christina Scharf, Ines Schroeder, Kirsi Manz, Ivanka Rathgeber, Marcus Gutmann, Johanna Biebl, Amrei Mehler-Klamt, Jana Huber, Inge Eberl, Eduard Kraft, Uli Fischer and Michael Zoller
    Citation: Critical Care 2024 28:112
  32. Optimal intensive care of patients undergoing valve surgery is a complex balancing act between sedation for monitoring and timely postoperative awakening. It remains unclear, if these requirements can be fulfi...

    Authors: Armin Niklas Flinspach, Florian Jürgen Raimann, Philipp Kaiser, Michaela Pfaff, Kai Zacharowski, Vanessa Neef and Elisabeth Hannah Adam
    Citation: Critical Care 2024 28:111
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    Citation: Critical Care 2024 28:110

    The original article was published in Critical Care 2021 25:310

    The original article was published in Critical Care 2021 25:318

    The original article was published in Critical Care 2021 25:317

    The original article was published in Critical Care 2021 25:309

    The original article was published in Critical Care 2021 25:316

    The original article was published in Critical Care 2021 25:315

    The original article was published in Critical Care 2021 25:313

    The original article was published in Critical Care 2021 25:314

    The original article was published in Critical Care 2021 25:312

    The original article was published in Critical Care 2021 25:311

  34. Prehospital triage and treatment of patients with acute coma is challenging for rescue services, as the underlying pathological conditions are highly heterogenous. Recently, glial fibrillary acidic protein (GF...

    Authors: Sabina Zylyftari, Sebastian Luger, Kristaps Blums, Stephan Barthelmes, Sebastian Humm, Hannsjörg Baum, Stephan Meckel, Jörg Braun, Gregor Lichy, Andreas Heilgeist, Love-Preet Kalra and Christian Foerch
    Citation: Critical Care 2024 28:109
  35. Vitamin D deficiency in critically ill patients is associated with poor outcomes, and vitamin D supplementation is recommended for patients with chronic kidney disease. Whether acute kidney injury (AKI) is ass...

    Authors: Lynda K. Cameron, Lesedi Ledwaba-Chapman, Kieran Voong, Geeta Hampson, Lui G. Forni, Nina Seylanova, Dominic J. Harrington, Rosario Lim, Aneta Bociek, Wang Yanzhong and Marlies Ostermann
    Citation: Critical Care 2024 28:108

    The Matters Arising to this article has been published in Critical Care 2024 28:175

  36. Pre-clinical studies suggest that dyssynchronous diaphragm contractions during mechanical ventilation may cause acute diaphragm dysfunction. We aimed to describe the variability in diaphragm contractile loadin...

    Authors: Benjamin Coiffard, Jose Dianti, Irene Telias, Laurent J. Brochard, Arthur S. Slutsky, Jennifer Beck, Christer Sinderby, Niall D. Ferguson and Ewan C. Goligher
    Citation: Critical Care 2024 28:107
  37. Facial appearance, whether consciously or subconsciously assessed, may affect clinical assessment and treatment strategies in the Intensive Care Unit (ICU). Nevertheless, the association between objective clin...

    Authors: Eline G. M. Cox, Bas C. T. van Bussel, Nerea Campillo Llamazares, Jan-Willem E. M. Sels, Marisa Onrust, Iwan C. C. van der Horst and Jacqueline Koeze
    Citation: Critical Care 2024 28:106
  38. Observational data suggest that the subset of patients with heart failure related CS (HF-CS) now predominate critical care admissions for CS. There are no dedicated HF-CS randomised control trials completed to...

    Authors: Stefan Williams, Antonis Kalakoutas, Segun Olusanya, Benedict Schrage, Guido Tavazzi, Anthony P. Carnicelli, Santiago Montero, Christophe Vandenbriele, Adriana Luk, Hoong Sern Lim, Sai Bhagra, Sascha C. Ott, Marta Farrero, Marc D. Samsky, Jamie L. W. Kennedy, Sounok Sen…
    Citation: Critical Care 2024 28:105