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  1. Natural language processing (NLP) may help evaluate the characteristics, prevalence, trajectory, treatment, and outcomes of behavioural disturbance phenotypes in critically ill patients.

    Authors: Marcus Young, Natasha E. Holmes, Kartik Kishore, Sobia Amjad, Michele Gaca, Ary Serpa Neto, Michael C. Reade and Rinaldo Bellomo
    Citation: Critical Care 2023 27:425
  2. Acute cor pulmonale (ACP) is prognostic in patients with acute respiratory distress syndrome (ARDS). Identification of paradoxical septal motion (PSM) using two-dimensional echocardiography is highly subjectiv...

    Authors: Bruno Evrard, Jean-Baptiste Woillard, Annick Legras, Misylias Bouaoud, Maeva Gourraud, Antoine Humeau, Marine Goudelin and Philippe Vignon
    Citation: Critical Care 2023 27:424
  3. Trauma-induced coagulopathy (TIC) is common in trauma patients with major hemorrhage. Prothrombin complex concentrate (PCC) is used as a potential treatment for the correction of TIC, but the efficacy, timing,...

    Authors: Ioannis Hannadjas, Arthur James, Ross Davenport, Charlotte Lindsay, Karim Brohi and Elaine Cole
    Citation: Critical Care 2023 27:422

    The Matters Arising to this article has been published in Critical Care 2023 27:454

  4. Authors: Tjitske S. R. van Engelen, Tom D. Y. Reijnders, Fleur P. Paling, Marc J. M. Bonten, Leen Timbermont, Surbhi Malhotra-Kumar, Jan A. J. W. Kluytmans, Hessel Peters-Sengers and Tom van der Poll
    Citation: Critical Care 2023 27:420

    The original article was published in Critical Care 2023 27:269

  5. Acute respiratory distress syndrome (ARDS) subphenotypes differ in outcomes and treatment responses. Subphenotypes in high-flow nasal oxygen (HFNO)-treated ARDS patients have not been investigated.

    Authors: Pierre-Louis Blot, Benjamin G. Chousterman, Manel Santafè, Jérôme Cartailler, Andrés Pacheco, Mònica Magret, Joan R. Masclans, Antoni Artigas, Oriol Roca and Marina García-de-Acilu
    Citation: Critical Care 2023 27:419
  6. Despite cefoxitin's in vitro resistance to hydrolysis by extended-spectrum beta-lactamases (ESBL), treatment of ESBL-producing Klebsiella pneumoniae (KP) infections with cefoxitin remains controversial. The aim o...

    Authors: Tanguy Dequidt, Sylvaine Bastian, Mathieu Nacher, Sébastien Breurec, Michel Carles, Guillaume Thiery, Laurent Camous, Benoit Tressieres, Marc Valette and Jean-David Pommier
    Citation: Critical Care 2023 27:418
  7. Sepsis is one of the leading causes of death. Treatment attempts targeting the immune response regularly fail in clinical trials. As HCMV latency can modulate the immune response and changes the immune cell co...

    Authors: M. Unterberg, S. F. Ehrentraut, T. Bracht, A. Wolf, H. Haberl, A. von Busch, K. Rump, D. Ziehe, M. Bazzi, P. Thon, B. Sitek, K. Marcus, M. Bayer, K. Schork, M. Eisenacher, B. Ellger…
    Citation: Critical Care 2023 27:417

    The Matters Arising to this article has been published in Critical Care 2023 27:464

    The Matters Arising to this article has been published in Critical Care 2023 27:445

  8. Although the defining elements of “acute respiratory distress syndrome” (ARDS) have been known for over a century, the syndrome was first described in 1967. Since then, despite several revisions of its concept...

    Authors: Jesús Villar, Tamas Szakmany, Giacomo Grasselli and Luigi Camporota
    Citation: Critical Care 2023 27:416
  9. The results of clinical and weaning readiness tests and the spontaneous breathing trial (SBT) are used to predict the success of the weaning process and extubation.

    Authors: Fabio Varón-Vega, Luis F. Giraldo-Cadavid, Ana María Uribe, Adriana Rincón, Jonathan Palacios, Stephanie Crevoisier, Eduardo Tuta-Quintero, Lina Ordoñez, Natalia Boada, Paola Rincón, Marcela Poveda and Pablo Monedero
    Citation: Critical Care 2023 27:414
  10. The role of haloperidol as treatment for ICU delirium and related symptoms remains controversial despite two recent large controlled trials evaluating its efficacy and safety. We sought to determine whether ha...

    Authors: Lisa Smit, Arjen J. C. Slooter, John W. Devlin, Zoran Trogrlic, Nicole G. M. Hunfeld, Robert Jan Osse, Huibert H. Ponssen, Arjen J. B. W. Brouwers, Jeannette F. Schoonderbeek, Koen S. Simons, Mark van den Boogaard, Judith A. Lens, Dirk P. Boer, Diederik A. M. P. J. Gommers, Wim J. R. Rietdijk and Mathieu van der Jagt
    Citation: Critical Care 2023 27:413
  11. It has been 50 years since the pulmonary artery catheter was introduced, but the actual use of pulmonary artery catheters in recent years is unknown. Some randomized controlled trials have reported no causalit...

    Authors: Kentaro Fukano, Yusuke Iizuka, Seiya Nishiyama, Koichi Yoshinaga, Shigehiko Uchino, Yusuke Sasabuchi and Masamitsu Sanui
    Citation: Critical Care 2023 27:412
  12. Authors: Jheng‑Yan Wu, Ya‑Wen Tsai, Wan‑Hsuan Hsu, Ting‑Hui Liu, Po‑Yu Huang, Min‑Hsiang Chuang, Mei‑Yuan Liu and Chih‑Cheng Lai
    Citation: Critical Care 2023 27:411

    The original article was published in Critical Care 2023 27:274

  13. To assess the association with outcomes of cardiac index (CI) and mixed venous oxygen saturation (SvO2) in comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA).

    Authors: Johannes Grand, Christian Hassager, Henrik Schmidt, Simon Mølstrøm, Benjamin Nyholm, Henrik Frederiksen Høigaard, Jordi S. Dahl, Martin Meyer, Rasmus P. Beske, Laust Obling, Jesper Kjaergaard and Jacob E. Møller
    Citation: Critical Care 2023 27:410

    The Matters Arising to this article has been published in Critical Care 2023 27:451

  14. Dual circulation is a common but underrecognized physiological occurrence associated with peripheral venoarterial extracorporeal membrane oxygenation (ECMO). Competitive flow will develop between blood ejected...

    Authors: Richa Asija, Justin A. Fried, Eric C. Siddall, Dana A. Mullin, Cara L. Agerstrand, Daniel Brodie, Joshua R. Sonett, Philippe H. Lemaitre and Darryl Abrams
    Citation: Critical Care 2023 27:408
  15. This study aimed to quantitatively analyse ultra-early brain diffusion-weighted magnetic resonance imaging (DW-MRI) findings to determine the apparent diffusion coefficient (ADC) threshold associated with neur...

    Authors: Jung A. Yoon, Changshin Kang, Jung Soo Park, Yeonho You, Jin Hong Min, Yong Nam In, Wonjoon Jeong, Hong Joon Ahn, In Ho Lee, Hye Seon Jeong, Byung Kook Lee and Jae Kwang Lee
    Citation: Critical Care 2023 27:407
  16. Venous thromboembolism (VTE) is a severe complication in critically ill patients, often resulting in death and long-term disability and is one of the major contributors to the global burden of disease. This st...

    Authors: Chengfu Guan, Fuxin Ma, Sijie Chang and Jinhua Zhang
    Citation: Critical Care 2023 27:406
  17. Shared decision-making is a joint process where patients, or their surrogates, and clinicians make health choices based on evidence and preferences. We aimed to determine the extent and predictors of shared de...

    Authors: Victoria Fleming, Abhinav Prasad, Connie Ge, Sybil Crawford, Shazeb Meraj, Catherine L. Hough, Bernard Lo, Shannon S. Carson, Jay Steingrub, Douglas B. White and Susanne Muehlschlegel
    Citation: Critical Care 2023 27:403
  18. Supplemental oxygen is commonly administered to patients after out-of-hospital cardiac arrest. However, the findings from studies on oxygen targeting for out-of-hospital cardiac arrest are inconclusive. Thus, ...

    Authors: Xin Cheng, Yu Zhang, Haidong Deng, Yuning Feng, Weelic Chong, Yang Hai, Pengfei Hao, Jialing He, Tiangui Li, Liyuan Peng, Peng Wang, Yangchun Xiao and Fang Fang
    Citation: Critical Care 2023 27:401

    The Matters Arising to this article has been published in Critical Care 2023 27:471

  19. Septic shock can be caused by a variety of mechanisms including direct effects of bacterial toxins such as endotoxin. Annually, approximately 5–7 million patients worldwide develop sepsis with very high endoto...

    Authors: John A. Kellum and Claudio Ronco
    Citation: Critical Care 2023 27:400
  20. Based on low-quality evidence, current nutrition guidelines recommend the delivery of high-dose protein in critically ill patients. The EFFORT Protein trial showed that higher protein dose is not associated wi...

    Authors: Christian Stoppe, Jayshil J. Patel, Alex Zarbock, Zheng-Yii Lee, Todd W. Rice, Bruno Mafrici, Rebecca Wehner, Man Hung Manuel Chan, Peter Chi Keung Lai, Kristen MacEachern, Pavlos Myrianthefs, Evdoxia Tsigou, Luis Ortiz-Reyes, Xuran Jiang, Andrew G. Day, M. Shahnaz Hasan…
    Citation: Critical Care 2023 27:399
  21. Although patients with interstitial pneumonia pattern (ILD-UIP) and acute exacerbation (AE) leading to severe acute respiratory failure may require invasive mechanical ventilation (MV), physiological data on l...

    Authors: Roberto Tonelli, Salvatore Grasso, Andrea Cortegiani, Lorenzo Ball, Ivana Castaniere, Luca Tabbì, Riccardo Fantini, Dario Andrisani, Filippo Gozzi, Antonio Moretti, Giulia Bruzzi, Linda Manicardi, Stefania Cerri, Anna Valeria Samarelli, Giulia Raineri, Francesco Murgolo…
    Citation: Critical Care 2023 27:398
  22. Appropriate antibiotic (AB) therapy remains a challenge in the intensive care unit (ICU). Procalcitonin (PCT)-guided AB stewardship could help optimize AB treatment and decrease AB-related adverse effects, but...

    Authors: Márton Papp, Nikolett Kiss, Máté Baka, Domonkos Trásy, László Zubek, Péter Fehérvári, Andrea Harnos, Caner Turan, Péter Hegyi and Zsolt Molnár
    Citation: Critical Care 2023 27:394
  23. Mega-dose sodium ascorbate (NaAscorbate) appears beneficial in experimental sepsis. However, its physiological effects in patients with septic shock are unknown.

    Authors: Fumitaka Yanase, Sofia Spano, Akinori Maeda, Anis Chaba, Thummaporn Naorungroj, Connie Pei Chen Ow, Yugeesh R. Lankadeva, Clive N. May, Ashenafi H. Betrie, Darius J. R. Lane, Glenn M. Eastwood, Mark P. Plummer and Rinaldo Bellomo
    Citation: Critical Care 2023 27:371
  24. Various approaches have been suggested to identify acute kidney injury (AKI) early and to initiate kidney-protective measures in patients at risk or with AKI. The objective of this study was to evaluate whethe...

    Authors: Chun Yin See, Heng-Chih Pan, Jui-Yi Chen, Chun-Yi Wu, Hung-Wei Liao, Yen-Ta Huang, Jung-Hua Liu, Vin-Cent Wu and Marlies Ostermann
    Citation: Critical Care 2023 27:390
  25. Low levels of high-density lipoprotein (HDL) cholesterol have been associated with higher rates and severity of infection. Alterations in inflammatory mediators and infection are associated with alterations in...

    Authors: Fergus Hamilton, Kasper Mønsted Pedersen, Peter Ghazal, Børge Grønne Nordestgaard and George Davey Smith
    Citation: Critical Care 2023 27:389
  26. Though early hypotension after pediatric in-hospital cardiac arrest (IHCA) is associated with inferior outcomes, ideal post-arrest blood pressure (BP) targets have not been established. We aimed to leverage pr...

    Authors: Monique M. Gardner, David A. Hehir, Ron W. Reeder, Tageldin Ahmed, Michael J. Bell, Robert A. Berg, Robert Bishop, Matthew Bochkoris, Candice Burns, Joseph A. Carcillo, Todd C. Carpenter, J. Michael Dean, J. Wesley Diddle, Myke Federman, Richard Fernandez, Ericka L. Fink…
    Citation: Critical Care 2023 27:388
  27. Neurological damage is the main cause of death or withdrawal of care in comatose survivors of cardiac arrest (CA). Hypoxemia and hyperoxemia following CA were described as potentially harmful, but reports were...

    Authors: S. Macherey-Meyer, S. Heyne, M. M. Meertens, S. Braumann, C. Hueser, V. Mauri, S. Baldus, S. Lee and C. Adler
    Citation: Critical Care 2023 27:387
  28. Sepsis-associated encephalopathy is a severe neurologic syndrome characterized by a diffuse dysfunction of the brain caused by sepsis. This review provides a concise overview of diagnostic tools and management...

    Authors: Romain Sonneville, Sarah Benghanem, Lina Jeantin, Etienne de Montmollin, Marc Doman, Augustin Gaudemer, Michael Thy and Jean-François Timsit
    Citation: Critical Care 2023 27:386
  29. Patients undergoing mechanical ventilation (MV) for COVID-19 exhibit an increased risk of ventilator-associated pneumonia (VAP). The occurrence of lung abscesses following VAP in these patients has been poorly...

    Authors: S. Hraiech, K. Ladjal, C. Guervilly, H. Hyvernat, L. Papazian, J. M. Forel, A. Lopez, N. Peres, J. Dellamonica, M. Leone and I. Gragueb-Chatti
    Citation: Critical Care 2023 27:385
  30. Regardless of the available antifungals, intraabdominal candidiasis (IAC) mortality continues to be high and represents a challenge for clinicians.

    Authors: Emilio Maseda, Ignacio Martín-Loeches, Rafael Zaragoza, Javier Pemán, Jesús Fortún, Santiago Grau, Gerardo Aguilar, Marina Varela, Marcio Borges, María-José Giménez and Alejandro Rodríguez
    Citation: Critical Care 2023 27:382
  31. Restoring plasma arginine levels through enteral administration of L-citrulline in critically ill patients may improve outcomes. We aimed to evaluate whether enteral L-citrulline administration reduced organ d...

    Authors: Jean-Marc Tadié, Clara Locher, Adel Maamar, Jean Reignier, Pierre Asfar, Morgane Commereuc, Mathieu Lesouhaitier, Murielle Gregoire, Estelle Le Pabic, Claude Bendavid, Caroline Moreau, Jean-Luc Diehl, Alain Gey, Eric Tartour, Yves Le Tulzo, Ronan Thibault…
    Citation: Critical Care 2023 27:381
  32. Out-of-plane (OOP) approach is frequently used for ultrasound-guided insertion of central venous catheter (CVC) owing to its simplicity but does not avoid mechanical complication. In-plane (IP) approach might ...

    Authors: Antoine Villa, Vladimir Hermand, Vincent Bonny, Gabriel Preda, Tomas Urbina, Maxime Gasperment, Paul Gabarre, Louai Missri, Jean-Luc Baudel, Daniel Zafimahazo, Jérémie Joffre, Hafid Ait-Oufella and Eric Maury
    Citation: Critical Care 2023 27:379
  33. Reintubation is a common complication in critically ill patients requiring mechanical ventilation. Although reintubation has been demonstrated to be associated with patient outcomes, its time definition varies...

    Authors: Aiko Tanaka, Yoshimitsu Shimomura, Akinori Uchiyama, Natsuko Tokuhira, Tetsuhisa Kitamura, Hirofumi Iwata, Haruka Hashimoto, Suguru Ishigaki, Yusuke Enokidani, Tomonori Yamashita, Yukiko Koyama, Naoya Iguchi, Takeshi Yoshida and Yuji Fujino
    Citation: Critical Care 2023 27:378

    The Matters Arising to this article has been published in Critical Care 2023 27:395