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Citation: Critical Care 2023 27:497
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Cumulative dose of epinephrine and mode of death after non-shockable out-of-hospital cardiac arrest: a registry-based study
Epinephrine increases the chances of return of spontaneous circulation (ROSC) in out-of-hospital cardiac arrest (OHCA), especially when the initial rhythm is non-shockable. However, this drug could also worsen...
Citation: Critical Care 2023 27:496 -
A prediction model for venous thromboembolism in the intensive care unit: flawed methods may lead to inaccurate predictions
Citation: Critical Care 2023 27:495 -
Association between selective digestive decontamination and decreased rate of acquired candidemia in mechanically ventilated ICU patients: a multicenter nationwide study
Candidemia is a high-risk complication among intensive care unit (ICU) patients. While selective digestive decontamination (SDD) has been shown to be effective in preventing ICU-acquired bacterial secondary in...
Citation: Critical Care 2023 27:494 -
Effects of a multilevel intervention of resistance training with or without beta-hydroxy-beta-methylbutyrate in medical ICU patients during entire hospitalisation: a four-arm multicentre randomised controlled trial
Intensive care unit-acquired weakness (ICU-AW) is a prevalent and severe issue among ICU patients. Resistance training and beta-hydroxy-beta-methylbutyrate (HMB) intervention have demonstrated the potential to...
Citation: Critical Care 2023 27:493 -
Reply to “Zimmermann, T., Lopez-Ayala, P. & Singer, M. Serial assessments of cardiac output and mixed venous oxygen saturation in comatose patients after out-of-hospital cardiac arrest”
Citation: Critical Care 2023 27:492 -
Modulation of mitochondrial function with near-infrared light reduces brain injury in a translational model of cardiac arrest
Brain injury is a leading cause of morbidity and mortality in patients resuscitated from cardiac arrest. Mitochondrial dysfunction contributes to brain injury following cardiac arrest; therefore, therapies tha...
Citation: Critical Care 2023 27:491 -
Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis
Sepsis is defined as a life-threatening syndrome caused by an unbalanced host response to infection. The role of interleukin (IL)-36 cytokines binding to the IL-36 receptor (IL-36R) in host response during sep...
Citation: Critical Care 2023 27:490 -
Publisher Correction: Early corticosteroids are associated with lower mortality in critically ill patients with COVID‑19: a cohort study
Citation: Critical Care 2023 27:489 -
Continuous monitoring of the lower limit of reactivity in traumatic brain injury patients: understanding what is feasible
Citation: Critical Care 2023 27:488 -
Interventions to promote cost-effectiveness in adult intensive care units: consensus statement and considerations for best practice from a multidisciplinary and multinational eDelphi study
There is limited evidence to guide interventions that promote cost-effectiveness in adult intensive care units (ICU). The aim of this consensus statement is to identify globally applicable interventions for be...
Citation: Critical Care 2023 27:487 -
Whole blood transcriptomics identifies subclasses of pediatric septic shock
Sepsis is a highly heterogeneous syndrome, which has hindered the development of effective therapies. This has prompted investigators to develop a precision medicine approach aimed at identifying biologically ...
Citation: Critical Care 2023 27:486 -
Do critical illness survivors with multimorbidity need a different model of care?
There is currently a lack of evidence on the optimal strategy to support patient recovery after critical illness. Previous research has largely focussed on rehabilitation interventions which aimed to address p...
Citation: Critical Care 2023 27:485 -
Early administration of high protein for critically ill patients with acute kidney injury?
Citation: Critical Care 2023 27:484 -
Reflections from the bedside: a nursing perspective on three decades of intensive care
Citation: Critical Care 2023 27:483 -
Meta-analysis of pulse pressure variation (PPV) and stroke volume variation (SVV) studies: a few rotten apples can spoil the whole barrel
Citation: Critical Care 2023 27:482 -
Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis
Proenkephalin A 119-159 (PENK) is freely filtered in the glomerulus with plasma levels correlating with glomerular filtration rate. Therefore, PENK has been proposed as an early indicator of acute kidney injur...
Citation: Critical Care 2023 27:481 -
Potential confounders in linking elevated S100A8/A9 to left ventricular dysfunction in septic shock patients
Citation: Critical Care 2023 27:480 -
Comparing outcomes of out-of-hospital cardiac arrest patients with initial shockable rhythm in Singapore and Osaka using population-based databases
Previous research indicated outcomes among refractory out-of-hospital cardiac arrest (OHCA) patients with initial shockable rhythm were different in Singapore and Osaka, Japan, possibly due to the differences ...
Citation: Critical Care 2023 27:479 -
Targeting the host response in sepsis: current approaches and future evidence
Sepsis, a dysregulated host response to infection characterized by organ failure, is one of the leading causes of death worldwide. Disbalances of the immune response play an important role in its pathophysiolo...
Citation: Critical Care 2023 27:478 -
Critical illness among patients experiencing homelessness: a retrospective cohort study
To understand the epidemiology and healthcare use of critically ill patients experiencing homelessness compared to critically ill patients with stable housing.
Citation: Critical Care 2023 27:477 -
Association of autoimmune diseases with the occurrence and 28-day mortality of sepsis: an observational and Mendelian randomization study
Observational studies have indicated a potential association between autoimmune diseases and the occurrence of sepsis, with an increased risk of mortality among affected patients. However, whether a causal rel...
Citation: Critical Care 2023 27:476 -
Iron as an emerging therapeutic target in critically ill patients
The multiple roles of iron in the body have been known for decades, particularly its involvement in iron overload diseases such as hemochromatosis. More recently, compelling evidence has emerged regarding the ...
Citation: Critical Care 2023 27:475 -
Remimazolam besylate versus propofol for deep sedation in critically ill patients: a randomized pilot study
To compare the efficacy and safety of remimazolam besylate and propofol for deep sedation in critically ill patients.
Citation: Critical Care 2023 27:474 -
Prognostic value of capillary refill time in adult patients: a systematic review with meta-analysis
Acute circulatory failure leads to tissue hypoperfusion. Capillary refill time (CRT) has been widely studied, but its predictive value remains debated. We conducted a meta-analysis to assess the ability of CRT...
Citation: Critical Care 2023 27:473 -
Dysnatremia at ICU admission and functional outcome of cardiac arrest: insights from four randomised controlled trials
To evaluate the potential association between early dysnatremia and 6-month functional outcome after cardiac arrest.
Citation: Critical Care 2023 27:472 -
Effects of lower versus higher oxygen targets on out-of-hospital cardiac arrest
Citation: Critical Care 2023 27:471 -
Combination of serum and peritoneal 1.3-beta-d-glucan can rule out intra-abdominal candidiasis in surgical critically ill patients: a multicenter prospective study
Intra-abdominal candidiasis (IAC) is difficult to predict in critically ill patients with intra-abdominal infection, leading to the overuse of antifungal treatments. Serum and peritoneal 1.3-beta-d-glucan (sBDG a...
Citation: Critical Care 2023 27:470 -
Publisher Correction to: Critical Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long‑term outcomes
Citation: Critical Care 2023 27:469 -
The use of checklists in the intensive care unit: a scoping review
Despite the extensive volume of research published on checklists in the intensive care unit (ICU), no review has been published on the broader role of checklists within the intensive care unit, their implement...
Citation: Critical Care 2023 27:468 -
Prognostic differences in sepsis caused by gram-negative bacteria and gram-positive bacteria: a systematic review and meta-analysis
Bacteria are the main pathogens that cause sepsis. The pathogenic mechanisms of sepsis caused by gram-negative and gram-positive bacteria are completely different, and their prognostic differences in sepsis re...
Citation: Critical Care 2023 27:467 -
Estimation of inspiratory effort using airway occlusion maneuvers in ventilated children: a secondary analysis of an ongoing randomized trial testing a lung and diaphragm protective ventilation strategy
Monitoring respiratory effort in ventilated patients is important to balance lung and diaphragm protection. Esophageal manometry remains the gold standard for monitoring respiratory effort but is invasive and ...
Citation: Critical Care 2023 27:466 -
Positive single-center randomized trials and subsequent multicenter randomized trials in critically ill patients: a systematic review
It is unclear how often survival benefits observed in single-center randomized controlled trials (sRCTs) involving critically ill patients are confirmed by subsequent multicenter randomized controlled trials (...
Citation: Critical Care 2023 27:465 -
Response to comment on human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis
Citation: Critical Care 2023 27:464 -
External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock
Acute kidney injury (AKI) occurs commonly in pediatric septic shock and increases morbidity and mortality. Early identification of high-risk patients can facilitate targeted intervention to improve outcomes. W...
Citation: Critical Care 2023 27:463 -
Effects of early versus delayed application of prone position on ventilation–perfusion mismatch in patients with acute respiratory distress syndrome: a prospective observational study
Prone position has been shown to improve oxygenation and survival in patients with early acute respiratory distress syndrome (ARDS). These beneficial effects are partly mediated by improved ventilation/perfusi...
Citation: Critical Care 2023 27:462 -
Evaluation of the sensory environment in a large tertiary ICU
ICU survival is improving. However, many patients leave ICU with ongoing cognitive, physical, and/or psychological impairments and reduced quality of life. Many of the reasons for these ongoing problems are un...
Citation: Critical Care 2023 27:461 -
Extending the ‘host response’ paradigm from sepsis to cardiogenic shock: evidence, limitations and opportunities
Recent clinical and research efforts in cardiogenic shock (CS) have largely focussed on the restoration of the low cardiac output state that is the conditio sine qua non of the clinical syndrome. This approach ha...
Citation: Critical Care 2023 27:460 -
An international RAND/UCLA expert panel to determine the optimal diagnosis and management of burn inhalation injury
Burn inhalation injury (BII) is a major cause of burn-related mortality and morbidity. Despite published practice guidelines, no consensus exists for the best strategies regarding diagnosis and management of B...
Citation: Critical Care 2023 27:459 -
Neutralization of extracellular histones by sodium-Β-O-methyl cellobioside sulfate in septic shock
Extracellular histones have been associated with severity and outcome in sepsis. The aim of the present study was to assess the effects of sodium-β-O-Methyl cellobioside sulfate (mCBS), a histone-neutralizing ...
Citation: Critical Care 2023 27:458 -
Dynamic relative regional lung strain estimated by computed tomography and electrical impedance tomography in ARDS patients
In the acute distress respiratory syndrome (ARDS), specific lung regions can be exposed to excessive strain due to heterogeneous disease, gravity-dependent lung collapse and injurious mechanical ventilation. C...
Citation: Critical Care 2023 27:457 -
Safety of interhospital transfer for critically ill COVID-19 patients
Citation: Critical Care 2023 27:456 -
Myocardial dysfunction assessed by speckle-tracking in good-grade subarachnoid hemorrhage patients (WFNS 1–2): a prospective observational study
Cardiac complications due to non-traumatic subarachnoid hemorrhage (SAH) are usually described using classical echocardiographic evaluation. Strain imaging appears to have better sensitivity than standard echo...
Citation: Critical Care 2023 27:455 -
Critical appraisal and concerns regarding a meta-analysis on prothrombin complex concentrate (PCC) for trauma-induced coagulopathy: unveiling methodological nuances and treatment variances
Citation: Critical Care 2023 27:454 -
The alternative renin–angiotensin system in critically ill patients: pathophysiology and therapeutic implications
The renin–angiotensin system (RAS) plays a crucial role in regulating blood pressure and the cardio-renal system. The classical RAS, mainly mediated by angiotensin I, angiotensin-converting enzyme, and angiote...
Citation: Critical Care 2023 27:453 -
In response to: multimodal neuromonitoring in traumatic brain injury patients: the search for the holy grail
Citation: Critical Care 2023 27:452 -
Serial assessments of cardiac output and mixed venous oxygen saturation in comatose patients after out-of-hospital cardiac arrest
Citation: Critical Care 2023 27:451 -
A systematic review and meta-analysis of the clinimetric properties of the core outcome measurement instruments for clinical effectiveness trials of nutritional and metabolic interventions in critical illness (CONCISE)
CONCISE is an internationally agreed minimum set of outcomes for use in nutritional and metabolic clinical research in critically ill adults. Clinicians and researchers need to be aware of the clinimetric prop...
Citation: Critical Care 2023 27:450 -
Pharmacokinetic and pharmacodynamic considerations for antifungal therapy optimisation in the treatment of intra-abdominal candidiasis
Intra-abdominal candidiasis (IAC) is one of the most common of invasive candidiasis observed in critically ill patients. It is associated with high mortality, with up to 50% of deaths attributable to delays in...
Citation: Critical Care 2023 27:449 -
Factors influencing withdrawal of life-supporting treatment in cervical spinal cord injury: a large multicenter observational cohort study
Traumatic spinal cord injury (SCI) leads to profound neurologic sequelae, and the provision of life-supporting treatment serves great importance among this patient population. The decision for withdrawal of li...
Citation: Critical Care 2023 27:448
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- ISSN: 1364-8535 (electronic)