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  1. Acute ischemic stroke (AIS) complicating an acute myocardial infarction (AMI) is not uncommon, but can severely worsen the clinical prognosis. This study aimed to investigate whether remote ischemic conditioni...

    Authors: Sijie Li, Xiurong Xing, Lanjing Wang, Jiali Xu, Changhong Ren, Yalin Li, Jing Wang, Zhi Liu, Heng Zhao, Wenbo Zhao and Xunming Ji
    Citation: Critical Care 2024 28:5
  2. Group A Streptococcus is responsible for severe and potentially lethal invasive conditions requiring intensive care unit (ICU) admission, such as streptococcal toxic shock-like syndrome (STSS). A rebound of invas...

    Authors: Arthur Orieux, Renaud Prevel, Margot Dumery, Jean-Baptiste Lascarrou, Noémie Zucman, Florian Reizine, Pierre Fillatre, Charles Detollenaere, Cédric Darreau, Nadiejda Antier, Mélanie Saint-Léger, Guillaume Schnell, Béatrice La Combe, Charlotte Guesdon, Franklin Bruna, Antoine Guillon…
    Citation: Critical Care 2024 28:4
  3. Surface electromyography (sEMG) can be used to measure the electrical activity of the respiratory muscles. The possible applications of sEMG span from patients suffering from acute respiratory failure to patie...

    Authors: A. H. Jonkman, R. S. P. Warnaar, W. Baccinelli, N. M. Carbon, R. F. D’Cruz, J. Doorduin, J. L. M. van Doorn, J. Elshof, L. Estrada-Petrocelli, J. Graßhoff, L. M. A. Heunks, A. A. Koopman, D. Langer, C. M. Moore, J. M. Nunez Silveira, E. Petersen…
    Citation: Critical Care 2024 28:2
  4. The utilization of video laryngoscopy (VL) has demonstrated superiority over direct laryngoscopy (DL) for intubation in surgical settings. However, its effectiveness in the intensive care unit and emergency de...

    Authors: Beatriz Araújo, André Rivera, Suzany Martins, Renatha Abreu, Paula Cassa, Maicon Silva and Alice Gallo de Moraes
    Citation: Critical Care 2024 28:1

    The Matters Arising to this article has been published in Critical Care 2024 28:27

  5. Epinephrine increases the chances of return of spontaneous circulation (ROSC) in out-of-hospital cardiac arrest (OHCA), especially when the initial rhythm is non-shockable. However, this drug could also worsen...

    Authors: François Javaudin, Wulfran Bougouin, Lucie Fanet, Jean-Luc Diehl, Daniel Jost, Frankie Beganton, Jean-Philippe Empana, Xavier Jouven, Frédéric Adnet, Lionel Lamhaut, Jean-Baptiste Lascarrou, Alain Cariou and Florence Dumas
    Citation: Critical Care 2023 27:496
  6. Candidemia is a high-risk complication among intensive care unit (ICU) patients. While selective digestive decontamination (SDD) has been shown to be effective in preventing ICU-acquired bacterial secondary in...

    Authors: Florian Reizine, Nicolas Massart, Vincent Joussellin, Anaïs Machut, Charles-Hervé Vacheron, Anne Savey, Arnaud Friggeri and Alain Lepape
    Citation: Critical Care 2023 27:494
  7. Intensive care unit-acquired weakness (ICU-AW) is a prevalent and severe issue among ICU patients. Resistance training and beta-hydroxy-beta-methylbutyrate (HMB) intervention have demonstrated the potential to...

    Authors: Ting-Ting Wu, Qiao-Ling Chen, Xiu-Xia Lin, Mei-Lian Xu, Xue-Xian Chen, Chen-Juan Luo, Yao-Ning Zhuang, Yue-Qing Wei, Jing-Bing Wu, Jing Xiong, Li-Li Chen and Hong Li
    Citation: Critical Care 2023 27:493
  8. Authors: Johannes Grand, Christian Hassager, Jesper Kjaergaard and Jacob E. Møller
    Citation: Critical Care 2023 27:492

    The original article was published in Critical Care 2023 27:410

    The original article was published in Critical Care 2023 27:451

  9. Brain injury is a leading cause of morbidity and mortality in patients resuscitated from cardiac arrest. Mitochondrial dysfunction contributes to brain injury following cardiac arrest; therefore, therapies tha...

    Authors: Joseph M. Wider, Erin Gruley, Paul T. Morse, Junmei Wan, Icksoo Lee, Anthony R. Anzell, Garrett M. Fogo, Jennifer Mathieu, Gerald Hish, Brian O’Neil, Robert W. Neumar, Karin Przyklenk, Maik Hüttemann and Thomas H. Sanderson
    Citation: Critical Care 2023 27:491
  10. Sepsis is defined as a life-threatening syndrome caused by an unbalanced host response to infection. The role of interleukin (IL)-36 cytokines binding to the IL-36 receptor (IL-36R) in host response during sep...

    Authors: Huachen Wang, Meixiang Wang, Junlan Chen, Hongda Hou, Zheng Guo, Hong Yang, Hua Tang and Bing Chen
    Citation: Critical Care 2023 27:490
  11. There is limited evidence to guide interventions that promote cost-effectiveness in adult intensive care units (ICU). The aim of this consensus statement is to identify globally applicable interventions for be...

    Authors: Amit Kansal, Jos M. Latour, Kay Choong See, Sumeet Rai, Maurizio Cecconi, Carl Britto, Andrew Conway Morris, Raymond Dominic Savio, Vinay M. Nadkarni, B. K. Rao and Rajesh Mishra
    Citation: Critical Care 2023 27:487

    The Correction to this article has been published in Critical Care 2024 28:121

  12. Sepsis is a highly heterogeneous syndrome, which has hindered the development of effective therapies. This has prompted investigators to develop a precision medicine approach aimed at identifying biologically ...

    Authors: Jamie O. Yang, Matt S. Zinter, Matteo Pellegrini, Man Yee Wong, Kinisha Gala, Daniela Markovic, Brian Nadel, Kerui Peng, Nguyen Do, Serghei Mangul, Vinay M. Nadkarni, Aaron Karlsberg, Dhrithi Deshpande, Manish J. Butte, Lisa Asaro, Michael Agus…
    Citation: Critical Care 2023 27:486
  13. There is currently a lack of evidence on the optimal strategy to support patient recovery after critical illness. Previous research has largely focussed on rehabilitation interventions which aimed to address p...

    Authors: Jonathan Stewart, Judy Bradley, Susan Smith, Joanne McPeake, Timothy Walsh, Kimberley Haines, Nina Leggett, Nigel Hart and Danny McAuley
    Citation: Critical Care 2023 27:485
  14. Proenkephalin A 119-159 (PENK) is freely filtered in the glomerulus with plasma levels correlating with glomerular filtration rate. Therefore, PENK has been proposed as an early indicator of acute kidney injur...

    Authors: Li-Chun Lin, Min-Hsiang Chuan, Jung-Hua Liu, Hung-Wei Liao, Leong L. Ng, Martin Magnusson, Amra Jujic, Heng-Chih Pan, Vin-Cent Wu and Lui G. Forni
    Citation: Critical Care 2023 27:481
  15. Previous research indicated outcomes among refractory out-of-hospital cardiac arrest (OHCA) patients with initial shockable rhythm were different in Singapore and Osaka, Japan, possibly due to the differences ...

    Authors: Yohei Okada, Nur Shahidah, Yih Yng Ng, Michael Y. C. Chia, Han Nee Gan, Benjamin S. H. Leong, Desmond R. Mao, Wei Ming Ng, Nausheen Edwin, Takeyuki Kiguchi, Norihiro Nishioka, Tetsuhisa Kitamura, Taku Iwami and Marcus Eng Hock Ong
    Citation: Critical Care 2023 27:479
  16. Observational studies have indicated a potential association between autoimmune diseases and the occurrence of sepsis, with an increased risk of mortality among affected patients. However, whether a causal rel...

    Authors: Hui Li, Xiaojun Pan, Sheng Zhang, Xuan Shen, Wan Li, Weifeng Shang, Zhenliang Wen, Sisi Huang, Limin Chen, Xu Zhang, Dechang Chen and Jiao Liu
    Citation: Critical Care 2023 27:476
  17. The multiple roles of iron in the body have been known for decades, particularly its involvement in iron overload diseases such as hemochromatosis. More recently, compelling evidence has emerged regarding the ...

    Authors: Coralie Grange, François Lux, Thomas Brichart, Laurent David, Aymeric Couturier, David E. Leaf, Bernard Allaouchiche and Olivier Tillement
    Citation: Critical Care 2023 27:475
  18. Acute circulatory failure leads to tissue hypoperfusion. Capillary refill time (CRT) has been widely studied, but its predictive value remains debated. We conducted a meta-analysis to assess the ability of CRT...

    Authors: Matthias Jacquet-Lagrèze, Aymeric Pernollet, Eduardo Kattan, Hafid Ait-Oufella, Delphine Chesnel, Martin Ruste, Rémi Schweizer, Bernard Allaouchiche, Glenn Hernandez and Jean-Luc Fellahi
    Citation: Critical Care 2023 27:473
  19. To evaluate the potential association between early dysnatremia and 6-month functional outcome after cardiac arrest.

    Authors: Jean Baptiste Lascarrou, Cyrielle Ermel, Alain Cariou, Timo Laitio, Hans Kirkegaard, Eldar Søreide, Anders M. Grejs, Matti Reinikainen, Gwenhael Colin, Fabio Silvio Taccone, Amélie Le Gouge and Markus B. Skrifvars
    Citation: Critical Care 2023 27:472
  20. Intra-abdominal candidiasis (IAC) is difficult to predict in critically ill patients with intra-abdominal infection, leading to the overuse of antifungal treatments. Serum and peritoneal 1.3-beta-d-glucan (sBDG a...

    Authors: Emmanuel Novy, Jérémie Rivière, Maxime Nguyen, Gaëlle Arfeuille, Guillaume Louis, Bélaïd Bouhemad, Julien Pottecher, Stéphane Hecketsweiler, Adeline Germain, François-Xavier Laithier, Marie-Reine Losser, Anne Debourgogne, Yohann Bernard, Hélène Rousseau, Cédric Baumann, Amandine Luc…
    Citation: Critical Care 2023 27:470
  21. Despite the extensive volume of research published on checklists in the intensive care unit (ICU), no review has been published on the broader role of checklists within the intensive care unit, their implement...

    Authors: Ethan J. Erikson, Daniel A. Edelman, Fiona M. Brewster, Stuart D. Marshall, Maryann C. Turner, Vineet V. Sarode and David J. Brewster
    Citation: Critical Care 2023 27:468
  22. Bacteria are the main pathogens that cause sepsis. The pathogenic mechanisms of sepsis caused by gram-negative and gram-positive bacteria are completely different, and their prognostic differences in sepsis re...

    Authors: Aling Tang, Yi Shi, Qingqing Dong, Sihui Wang, Yao Ge, Chenyan Wang, Zhimin Gong, Weizhen Zhang and Wei Chen
    Citation: Critical Care 2023 27:467
  23. Monitoring respiratory effort in ventilated patients is important to balance lung and diaphragm protection. Esophageal manometry remains the gold standard for monitoring respiratory effort but is invasive and ...

    Authors: Yukie Ito, Matías G. Herrera, Justin C. Hotz, Miyako Kyogoku, Christopher J. L. Newth, Anoopindar K. Bhalla, Muneyuki Takeuchi and Robinder G. Khemani
    Citation: Critical Care 2023 27:466
  24. It is unclear how often survival benefits observed in single-center randomized controlled trials (sRCTs) involving critically ill patients are confirmed by subsequent multicenter randomized controlled trials (...

    Authors: Yuki Kotani, Stefano Turi, Alessandro Ortalda, Martina Baiardo Redaelli, Cristiano Marchetti, Giovanni Landoni and Rinaldo Bellomo
    Citation: Critical Care 2023 27:465
  25. Acute kidney injury (AKI) occurs commonly in pediatric septic shock and increases morbidity and mortality. Early identification of high-risk patients can facilitate targeted intervention to improve outcomes. W...

    Authors: Natalja L. Stanski, Rajit K. Basu, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Neal J. Thomas, Torrey Baines, Bereketeab Haileselassie, Scott L. Weiss, Mihir R. Atreya, Andrew J. Lautz, Basilia Zingarelli, Stephen W. Standage…
    Citation: Critical Care 2023 27:463
  26. Prone position has been shown to improve oxygenation and survival in patients with early acute respiratory distress syndrome (ARDS). These beneficial effects are partly mediated by improved ventilation/perfusi...

    Authors: Xueyan Yuan, Zhanqi Zhao, Yali Chao, Dongyu Chen, Hui Chen, Rui Zhang, Songqiao Liu, Jianfeng Xie, Yi Yang, Haibo Qiu, Leo Heunks and Ling Liu
    Citation: Critical Care 2023 27:462

    The Matters Arising to this article has been published in Critical Care 2024 28:129

  27. ICU survival is improving. However, many patients leave ICU with ongoing cognitive, physical, and/or psychological impairments and reduced quality of life. Many of the reasons for these ongoing problems are un...

    Authors: Oystein Tronstad, Dylan Flaws, Sue Patterson, Robert Holdsworth, Veronica Garcia-Hansen, Francisca Rodriguez Leonard, Ruth Ong, Stephanie Yerkovich and John F. Fraser
    Citation: Critical Care 2023 27:461
  28. Recent clinical and research efforts in cardiogenic shock (CS) have largely focussed on the restoration of the low cardiac output state that is the conditio sine qua non of the clinical syndrome. This approach ha...

    Authors: Marie Buckel, Patrick Maclean, Julian C. Knight, Patrick R. Lawler and Alastair G. Proudfoot
    Citation: Critical Care 2023 27:460
  29. Burn inhalation injury (BII) is a major cause of burn-related mortality and morbidity. Despite published practice guidelines, no consensus exists for the best strategies regarding diagnosis and management of B...

    Authors: Helena Milton-Jones, Sabri Soussi, Roger Davies, Emmanuel Charbonney, Walton N. Charles, Heather Cleland, Ken Dunn, Dashiell Gantner, Julian Giles, Marc Jeschke, Nicole Lee, Matthieu Legrand, Joanne Lloyd, Ignacio Martin-Loeches, Olivier Pantet, Mark Samaan…
    Citation: Critical Care 2023 27:459
  30. Extracellular histones have been associated with severity and outcome in sepsis. The aim of the present study was to assess the effects of sodium-β-O-Methyl cellobioside sulfate (mCBS), a histone-neutralizing ...

    Authors: Bruno Garcia, Fuhong Su, Laurence Dewachter, Yong Wang, Ning Li, Myriam Remmelink, Marie Van Eycken, Amina Khaldi, Raphaël Favory, Antoine Herpain, Anthony Moreau, Alexander Moiroux-Sahraoui, Francesca Manicone, Filippo Annoni, Lin Shi, Jean-Louis Vincent…
    Citation: Critical Care 2023 27:458
  31. In the acute distress respiratory syndrome (ARDS), specific lung regions can be exposed to excessive strain due to heterogeneous disease, gravity-dependent lung collapse and injurious mechanical ventilation. C...

    Authors: Roberto Brito, Caio C. A. Morais, Marioli T. Lazo, Dannette V. Guiñez, Abraham I. J. Gajardo, Daniel H. Arellano, Marcelo B. P. Amato and Rodrigo A. Cornejo
    Citation: Critical Care 2023 27:457
  32. Cardiac complications due to non-traumatic subarachnoid hemorrhage (SAH) are usually described using classical echocardiographic evaluation. Strain imaging appears to have better sensitivity than standard echo...

    Authors: Hugues de Courson, Grégoire Chadefaux, Alexandre Loiseau, Delphine Georges and Matthieu Biais
    Citation: Critical Care 2023 27:455

    The Matters Arising to this article has been published in Critical Care 2024 28:103

    The Matters Arising to this article has been published in Critical Care 2024 28:21

  33. Authors: Bruno Caldeira Antônio, Maiara Sulzbach Denardin, Henrique Alexsander Ferreira Neves and Eduardo Messias Hirano Padrao
    Citation: Critical Care 2023 27:454

    The original article was published in Critical Care 2023 27:422