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  1. The oXiris is a novel filter for continuous renal replacement therapy (CRRT) featuring an adsorption coating to adsorb endotoxins and remove inflammatory mediators. Given that no consensus has been reached on ...

    Authors: Guizhong Wang, Yuxuan He, Qingling Guo, Ying Zhao, Jie He, Yue Chen, Weijia Chen, Yi Zhou, Zichong Peng, Ke Deng, Jianbin Guan, Wenting Xie, Ping Chang and Zhanguo Liu
    Citation: Critical Care 2023 27:275
    Content type: Review Published on:

    The Correspondence to this article has been published in Critical Care 2023 27:314

    The Comment to this article has been published in Critical Care 2023 27:305

  2. This systematic review and meta-analysis aimed to investigate the clinical efficacy and safety of systemic corticosteroids in the treatment of patients with severe community-acquired pneumonia (sCAP).

    Authors: Jheng-Yan Wu, Ya-Wen Tsai, Wan-Hsuan Hsu, Ting-Hui Liu, Po-Yu Huang, Min-Hsiang Chuang, Mei-Yuan Liu and Chih-Cheng Lai
    Citation: Critical Care 2023 27:274
    Content type: Research Published on:

    The Correction to this article has been published in Critical Care 2023 27:411

    The Matters Arising to this article has been published in Critical Care 2023 27:358

    The Comment to this article has been published in Critical Care 2023 27:348

    The Correspondence to this article has been published in Critical Care 2023 27:336

    The Comment to this article has been published in Critical Care 2023 27:296

  3. Airway opening pressure (AOP) detection and measurement are essential for assessing respiratory mechanics and adapting ventilation. We propose a novel approach for AOP assessment during volume assist control v...

    Authors: Anne-Fleur Haudebourg, Elsa Moncomble, Arnaud Lesimple, Flora Delamaire, Bruno Louis, Armand Mekontso Dessap, Alain Mercat, Jean-Christophe Richard, François Beloncle and Guillaume Carteaux
    Citation: Critical Care 2023 27:273
    Content type: Research Published on:

  4. In critically ill patients, measured creatinine clearance (CrCl) is the most reliable method to evaluate glomerular filtration rate in routine clinical practice and may vary subsequently on a day-to-day basis....

    Authors: Chao-Yuan Huang, Fabian Güiza, Pieter Wouters, Liese Mebis, Giorgia Carra, Jan Gunst, Philippe Meersseman, Michael Casaer, Greet Van den Berghe, Greet De Vlieger and Geert Meyfroidt
    Citation: Critical Care 2023 27:272
    Content type: Research Published on:

  7. Immune suppression has been implicated in the occurrence of pneumonia in critically ill patients. We tested the hypothesis that Intensive Care Unit (ICU)-acquired pneumonia is associated with broad host immune...

    Authors: Tjitske S. R. van Engelen, Tom D. Y. Reijnders, Fleur P. Paling, Marc J. M. Bonten, Leen Timbermont, Surbhi Malhotra-Kumar, Jan A. J. W. Kluytmans, Hessel Peters-Sengers and Tom van der Poll
    Citation: Critical Care 2023 27:269
    Content type: Research Published on:

    The Correction to this article has been published in Critical Care 2023 27:420

  8. Individualised optimisation of mechanical ventilation (MV) remains cumbersome in modern intensive care medicine. Computerised, model-based support systems could help in tailoring MV settings to the complex int...

    Authors: R. S. P. Warnaar, M. P. Mulder, L. Fresiello, A. D. Cornet, L. M. A. Heunks, D. W. Donker and E. Oppersma
    Citation: Critical Care 2023 27:268
    Content type: Research Published on:

  9. To which extent trauma- induced disturbances in ionized calcium (iCa2+) levels have a linear relationship with adverse outcomes remains controversial. The goal of this study was to determine the association be...

    Authors: Dries Helsloot, Mark Fitzgerald, Rolf Lefering, Sandra Verelst and Carlo Missant
    Citation: Critical Care 2023 27:267
    Content type: Research Published on:

  11. Definitions for massive transfusion (MT) vary widely between studies, contributing to challenges in interpretation of research findings and practice evaluation. In this first systematic review, we aimed to ide...

    Authors: Victor S. Lin, Emily Sun, Serine Yau, Chathuri Abeyakoon, Georgia Seamer, Simran Bhopal, Harriet Tucker, Carolyn Doree, Susan J. Brunskill, Zoe K. McQuilten, Simon J. Stanworth, Erica M. Wood and Laura Green
    Citation: Critical Care 2023 27:265
    Content type: Review Published on:

  12. During the COVID-19 pandemic, several centers had independently reported extending prone positioning beyond 24 h. Most of these centers reported maintaining patients in prone position until significant clinica...

    Authors: Thaïs Walter and Jean-Damien Ricard
    Citation: Critical Care 2023 27:264
    Content type: Review Published on:

  13. Acute respiratory distress syndrome (ARDS) is etiologically and clinically a heterogeneous disease. Its diagnostic characteristics and subtype classification, and the application of these features to treatment...

    Authors: Youjin Chang, Hyun Ju Yoo, Su Jung Kim, Kwangha Lee, Chae-Man Lim, Sang-Bum Hong, Younsuck Koh and Jin Won Huh
    Citation: Critical Care 2023 27:263
    Content type: Research Published on:

  14. Several noninvasive ventilatory supports rely in their design on high oxygen consumption which may precipitate oxygen shortage, as experienced during the COVID-19 pandemic. In this bench-to-bedside study, we a...

    Authors: Eloïse de Beaufort, Guillaume Carteaux, François Morin, Arnaud Lesimple, Anne-Fleur Haudebourg, Emeline Fresnel, Damien Duval, Alexandre Broc, Alain Mercat, Laurent Brochard, Dominique Savary, François Beloncle, Armand Mekontso Dessap and Jean-Christophe Richard
    Citation: Critical Care 2023 27:262
    Content type: Research Published on:

  15. Personalization of ICU nutrition is essential to future of critical care. Recommendations from American/European guidelines and practice suggestions incorporating recent literature are presented. Low-dose ente...

    Authors: Paul E. Wischmeyer, Danielle E. Bear, Mette M. Berger, Elisabeth De Waele, Jan Gunst, Stephen A. McClave, Carla M. Prado, Zudin Puthucheary, Emma J. Ridley, Greet Van den Berghe and Arthur R. H. van Zanten
    Citation: Critical Care 2023 27:261
    Content type: Review Published on:

  16. Sepsis-associated acute kidney injury (SA-AKI) is associated with high morbidity, with no current therapies available beyond continuous renal replacement therapy (CRRT). Systemic inflammation and endothelial d...

    Authors: Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder…
    Citation: Critical Care 2023 27:260
    Content type: Research Published on:

  17. Acute-on-chronic liver failure (ACLF) has been recognized as a severe clinical syndrome based on the acute deterioration of chronic liver disease and is characterized by organ failure and high short-term morta...

    Authors: Jinjin Luo, Jiaqi Li, Peng Li, Xi Liang, Hozeifa Mohamed Hassan, Richard Moreau and Jun Li
    Citation: Critical Care 2023 27:259
    Content type: Review Published on:

  18. The optimal feeding strategy in critically ill patients is a matter of debate, with current guidelines recommending different strategies regarding energy and protein targets. Several recent trials have added t...

    Authors: Annika Reintam Blaser, Olav Rooyackers and Danielle E. Bear
    Citation: Critical Care 2023 27:258
    Content type: Review Published on:

  19. Interpreting point-of-care lung ultrasound (LUS) images from intensive care unit (ICU) patients can be challenging, especially in low- and middle- income countries (LMICs) where there is limited training avail...

    Authors: Phung Tran Huy Nhat, Nguyen Van Hao, Phan Vinh Tho, Hamideh Kerdegari, Luigi Pisani, Le Ngoc Minh Thu, Le Thanh Phuong, Ha Thi Hai Duong, Duong Bich Thuy, Angela McBride, Miguel Xochicale, Marcus J. Schultz, Reza Razavi, Andrew P. King, Louise Thwaites, Nguyen Van Vinh Chau…
    Citation: Critical Care 2023 27:257
    Content type: Research Published on:

  20. A tele-emergency medical service with a remote emergency physician for severe prehospital emergencies may overcome the increasing number of emergency calls and shortage of emergency medical service providers. ...

    Authors: Ana Kowark, Marc Felzen, Sebastian Ziemann, Stephanie Wied, Michael Czaplik, Stefan K. Beckers, Jörg C. Brokmann, Ralf-Dieter Hilgers and Rolf Rossaint
    Citation: Critical Care 2023 27:256
    Content type: Research Published on:

  22. Medical technology innovation has improved patient monitoring in perioperative and intensive care medicine and continuous improvement in the technology is now a central focus in this field. Because data densit...

    Authors: Greta Gasciauskaite, Justyna Lunkiewicz, Tadzio R. Roche, Donat R. Spahn, Christoph B. Nöthiger and David W. Tscholl
    Citation: Critical Care 2023 27:254
    Content type: Review Published on:

  24. Extracorporeal cardiopulmonary resuscitation (ECPR) is rapidly becoming a common treatment strategy for patients with refractory cardiac arrest. Despite its benefits, ECPR raises a variety of ethical concerns ...

    Authors: Hiromichi Naito, Masaaki Sakuraya, Takashi Hongo, Hiroaki Takada, Tetsuya Yumoto, Takashi Yorifuji, Toru Hifumi, Akihiko Inoue, Tetsuya Sakamoto, Yasuhiro Kuroda and Atsunori Nakao
    Citation: Critical Care 2023 27:252
    Content type: Research Published on:

  25. Withholding parenteral nutrition (PN) until one week after PICU admission facilitated recovery from critical illness and protected against emotional and behavioral problems 4 years later. However, the interven...

    Authors: Jan Gunst, Astrid De Bruyn, An Jacobs, Lies Langouche, Inge Derese, Karolijn Dulfer, Fabian Güiza, Gonzalo Garcia Guerra, Pieter J. Wouters, Koen F. Joosten, Sascha C. Verbruggen, Ilse Vanhorebeek and Greet Van den Berghe
    Citation: Critical Care 2023 27:251
    Content type: Research Published on:

  26. Sepsis is associated with significant mortality. Yet, there are no efficacious therapies beyond antibiotics. PCSK9 loss-of-function (LOF) and inhibition, through enhanced low-density lipoprotein receptor (LDLR) m...

    Authors: Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder…
    Citation: Critical Care 2023 27:250
    Content type: Research Published on:

  28. The significance of detecting human herpesvirus 7 (HHV-7) in the lower respiratory tract of patients with severe pneumonia is unclear. This study aims to evaluate the clinical characteristics and prognosis of ...

    Authors: Jun Xu, Lin Zhong, Huanzhang Shao, Qianqian Wang, Muhua Dai, Peng Shen, Yonghui Xiong, Weijun Zhang, Xutao Deng, Mingqiang Wang, Yue Zhu, Xindie Reng, Yongpo Jiang, Mengyuan Chen, Chengcong Zhu, Xueling Fang…
    Citation: Critical Care 2023 27:248
    Content type: Brief Report Published on:

  29. Acute brain injury (ABI) covers various clinical entities that may require invasive mechanical ventilation (MV) in the intensive care unit (ICU). The goal of MV, which is to protect the lung and the brain from...

    Authors: S. Frisvold, S. Coppola, S. Ehrmann, D. Chiumello and Claude Guérin
    Citation: Critical Care 2023 27:247
    Content type: Review Published on:

  31. Polymyxin B hemadsorption (PMX-HA) reduces blood endotoxin levels, but characteristics of patients with sepsis likely to benefit from PMX-HA are not well known. We sought to identify patient subgroups likely t...

    Authors: Itsuki Osawa, Tadahiro Goto, Daisuke Kudo, Mineji Hayakawa, Kazuma Yamakawa, Shigeki Kushimoto, Debra M. Foster, John A. Kellum and Kent Doi
    Citation: Critical Care 2023 27:245
    Content type: Research Published on:

    The Correspondence to this article has been published in Critical Care 2023 27:327

    The Correspondence to this article has been published in Critical Care 2023 27:284

  32. Specialized diets enriched with immune nutrients could be an important supplement in patients (pts) with acute traumatic brain injury (TBI). Omega-3 and arginine may interact with immune response and microbiot...

    Authors: A. Cotoia, R. Paradiso, G. Ferrara, G. Borriello, F. Santoro, I. Spina, L. Mirabella, K. Mariano, G. Fusco, G. Cinnella and P. Singer
    Citation: Critical Care 2023 27:244
    Content type: Research Published on:

  33. The CytoSorb therapy in COVID-19 (CTC) registry evaluated the clinical performance and treatment parameters of extracorporeal hemoadsorption integrated with veno-venous extracorporeal membrane oxygenation (VV ...

    Authors: J. W. Awori Hayanga, Tae Song, Lucian Durham, Lawrence Garrison, Deane Smith, Zsolt Molnar, Joerg Scheier, Efthymios N. Deliargyris and Nader Moazami
    Citation: Critical Care 2023 27:243
    Content type: Research Published on:

    The Correspondence to this article has been published in Critical Care 2023 27:421

    The Correspondence to this article has been published in Critical Care 2023 27:297

  35. In recent years, numerous dosing studies have been conducted to optimize therapeutic antibiotic exposures in patients with serious infections. These studies have led to the inclusion of dose optimization recom...

    Authors: Paul G. Williams, Alexis Tabah, Menino Osbert Cotta, Indy Sandaradura, Salmaan Kanji, Marc H. Scheetz, Sahand Imani, Muhammed Elhadi, Sònia Luque-Pardos, Natalie Schellack, Cristina Sanches, Jean-Francois Timsit, Jiao Xie, Andras Farkas, Kathryn Wilks and Jason A. Roberts
    Citation: Critical Care 2023 27:241
    Content type: Research Published on:

  36. Benefit of early awake prone positioning for COVID-19 patients hospitalised in medical wards and who need oxygen therapy remains to be demonstrated. The question was considered at the time of COVID-19 pandemic...

    Authors: Mai-Anh Nay, Raphaël Hindre, Christophe Perrin, Jérémy Clément, Laurent Plantier, Aymeric Sève, Sylvie Druelle, Marine Morrier, Jean-Baptiste Lainé, Léa Colombain, Grégory Corvaisier, Nicolas Bizien, Xavier Pouget-Abadie, Adrien Bigot, Simon Jamard, Elsa Nyamankolly…
    Citation: Critical Care 2023 27:240
    Content type: Research Published on:

    The Matters Arising to this article has been published in Critical Care 2023 27:393

  37. Animal models of acute respiratory distress syndrome (ARDS) do not completely resemble human ARDS, struggling translational research. We aimed to characterize a porcine model of ARDS induced by pneumonia—the m...

    Authors: Enric Barbeta, Marta Arrieta, Ana Motos, Joaquim Bobi, Hua Yang, Minlan Yang, Giacomo Tanzella, Pierluigi Di Ginnatale, Stefano Nogas, Carmen Rosa Vargas, Roberto Cabrera, Denise Battaglini, Andrea Meli, Kasra Kiarostami, Nil Vázquez, Laia Fernández-Barat…
    Citation: Critical Care 2023 27:239
    Content type: Perspective Published on:

  40. Sepsis is common, deadly, and heterogenous. Prior analyses of patients with sepsis and septic shock in New York State showed a risk-adjusted association between more rapid antibiotic administration and bundled...

    Authors: Anne Yang, Jason N. Kennedy, Katherine M. Reitz, Gary Phillips, Kathleen M. Terry, Mitchell M. Levy, Derek C. Angus and Christopher W. Seymour
    Citation: Critical Care 2023 27:236
    Content type: Research Published on:

  41. Cerebral autoregulation (CA) can be impaired in patients with delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). The Pressure Reactivity Index (PRx, correlation of blood pressure and...

    Authors: Nick Kastenholz, Murad Megjhani, Catharina Conzen-Dilger, Walid Albanna, Michael Veldeman, Daniel Nametz, Soon Bin Kwon, Henna Schulze-Steinen, Hani Ridwan, Hans Clusmann, Gerrit Alexander Schubert, Soojin Park and Miriam Weiss
    Citation: Critical Care 2023 27:235
    Content type: Research Published on:

  42. Angiopoietin-2 (Ang-2) is associated with vascular endothelial injury and permeability in the acute respiratory distress syndrome (ARDS) and sepsis. Elevated circulating Ang-2 levels may identify critically il...

    Authors: Carrie M. Rosenberger, Katherine D. Wick, Hanjing Zhuo, Nelson Wu, Yue Chen, Sharookh B. Kapadia, Alessander Guimaraes, Diana Chang, David F. Choy, Hubert Chen, Melicent Peck, Kathryn M. Sullivan, Serena Ke, Alejandra Jauregui, Aleksandra Leligdowicz, Pratik Sinha…
    Citation: Critical Care 2023 27:234
    Content type: Brief Report Published on:

  43. In ARDS, the PEEP level associated with the best respiratory system compliance is often selected; however, intra-tidal recruitment can increase compliance, falsely suggesting improvement in baseline mechanics....

    Authors: Francesco Mojoli, Marco Pozzi, Eric Arisi, Silvia Mongodi, Anita Orlando, Giuseppe Maggio, Federico Capra Marzani and Laurent Brochard
    Citation: Critical Care 2023 27:233
    Content type: Research Published on:

    The Correspondence to this article has been published in Critical Care 2023 27:306

  44. The appropriate administration regimen of polymyxin B is yet controversial. The present study aimed to explore the optimal dose of polymyxin B under therapeutic drug monitoring (TDM) guidance.

    Authors: Shaohua Liu, Ying Wu, Shaoyan Qi, Huanzhang Shao, Min Feng, Lihua Xing, Hongmei Liu, Yanqiu Gao, Zhiqiang Zhu, Shuguang Zhang, Yuming Du, Yibin Lu, Jing Yang, Pingyan Chen and Tongwen Sun
    Citation: Critical Care 2023 27:232
    Content type: Research Published on:

  46. Sepsis-induced endothelial dysfunction is proposed to cause angiotensin-converting enzyme (ACE) dysfunction and renin–angiotensin–aldosterone system (RAAS) derangement, exacerbating vasodilatory shock and acut...

    Authors: Naomi Pode-Shakked, Giovanni Ceschia, James E. Rose, Stuart L. Goldstein and Natalja L. Stanski
    Citation: Critical Care 2023 27:230
    Content type: Brief Report Published on:

  47. Numerous epidemiological studies investigating gender-dependent clinical outcomes in sepsis have shown conflicting evidence. This study aimed to investigate the effect of gender on in-hospital mortality due to...

    Authors: Ryoung-Eun Ko, Danbee Kang, Juhee Cho, Soo Jin Na, Chi Ryang Chung, Sung Yoon Lim, Yeon Joo Lee, Sunghoon Park, Dong Kyu Oh, Su Yeon Lee, Mi Hyeon Park, Haein Lee, Chae-Man Lim and Gee Young Suh
    Citation: Critical Care 2023 27:229
    Content type: Research Published on:

  48. To evaluate the safety, feasibility, and efficacy of combined adrenergic blockade with propranolol and clonidine in patients with severe traumatic brain injury (TBI).

    Authors: Mina F. Nordness, Amelia W. Maiga, Laura D. Wilson, Tatsuki Koyama, Erika L. Rivera, Shayan Rakhit, Michael de Riesthal, Cari L. Motuzas, Madison R. Cook, Deepak K. Gupta, James C. Jackson, Shawniqua Williams Roberson, William J. Meurer, Roger J. Lewis, Geoffrey T. Manley, Pratik P. Pandharipande…
    Citation: Critical Care 2023 27:228
    Content type: Research Published on:
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  • ISSN: 1364-8535 (electronic)

Critical Care

ISSN: 1364-8535