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  1. Although non-invasive respiratory management strategies have been implemented to avoid intubation, patients with de novo acute hypoxaemic respiratory failure (AHRF) are high risk of treatment failure. In the p...

    Authors: Masaaki Sakuraya, Hiromu Okano, Tomoyuki Masuyama, Shunsuke Kimata and Satoshi Hokari

    Citation: Critical Care 2021 25:414

    Content type: Research

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  2. Sepsis is often associated with multiple organ failure; however, changes in brain volume with sepsis are not well understood. We assessed brain atrophy in the acute phase of sepsis using brain computed tomogra...

    Authors: Ryuta Nakae, Tetsuro Sekine, Takashi Tagami, Yasuo Murai, Eigo Kodani, Geoffrey Warnock, Hidetaka Sato, Akio Morita, Hiroyuki Yokota and Shoji Yokobori

    Citation: Critical Care 2021 25:411

    Content type: Research

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  3. There is limited information about the long-term outcome of patients suffering from acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (VV ECMO). Most stu...

    Authors: Jonathan Rilinger, Klara Krötzsch, Xavier Bemtgen, Markus Jäckel, Viviane Zotzmann, Corinna N. Lang, Klaus Kaier, Daniel Duerschmied, Alexander Supady, Christoph Bode, Dawid L. Staudacher and Tobias Wengenmayer

    Citation: Critical Care 2021 25:410

    Content type: Research

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  4. The International Liaison Committee on Resuscitation recommends that dispatchers provide instructions to perform compression-only cardiopulmonary resuscitation (CPR) to callers responding to adults with out-of...

    Authors: Yoshikazu Goto, Akira Funada, Tetsuo Maeda and Yumiko Goto

    Citation: Critical Care 2021 25:408

    Content type: Research

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  5. The use of ultrasonography in the intensive care unit (ICU) is steadily increasing but is usually restricted to examinations of single organs or organ systems. In this study, we combine the ultrasound approach...

    Authors: Stefan Schmidt, Jana-Katharina Dieks, Michael Quintel and Onnen Moerer

    Citation: Critical Care 2021 25:405

    Content type: Research

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  6. Identifying new effective treatments for the acute respiratory distress syndrome (ARDS), including COVID-19 ARDS, remains a challenge. The field of ARDS investigation is moving increasingly toward innovative a...

    Authors: Katherine D. Wick, Daniel F. McAuley, Joseph E. Levitt, Jeremy R. Beitler, Djillali Annane, Elisabeth D. Riviello, Carolyn S. Calfee and Michael A. Matthay

    Citation: Critical Care 2021 25:404

    Content type: Review

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  7. Evidence about the impact of the pandemic of COVID-19 on the incidence rates of blood cultures contaminations and bloodstream infections in intensive care units (ICUs) remains scant. The objective of this stud...

    Authors: Lauro Damonti, Andreas Kronenberg, Jonas Marschall, Philipp Jent, Rami Sommerstein, Marlieke E. A. De Kraker, Stephan Harbarth, Michael Gasser and Niccolò Buetti

    Citation: Critical Care 2021 25:403

    Content type: Research

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  8. This study investigated temporal trends in the treatment and mortality of patients with cardiogenic shock (CS) in Taiwan in relation to acute myocardial infarction (AMI) accreditation implemented in 2009 and t...

    Authors: Shih-Chieh Chien, Chien-Yi Hsu, Hung-Yi Liu, Chao-Feng Lin, Chung-Lieh Hung, Chun-Yao Huang and Li-Nien Chien

    Citation: Critical Care 2021 25:402

    Content type: Research

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  9. The coronavirus disease-19 (COVID-19) pandemic had a relatively minimal direct impact on critical illness in children compared to adults. However, children and paediatric intensive care units (PICUs) were affe...

    Authors: Hari Krishnan Kanthimathinathan, Hannah Buckley, Peter J. Davis, Richard G. Feltbower, Caroline Lamming, Lee Norman, Lyn Palmer, Mark J. Peters, Adrian Plunkett, Padmanabhan Ramnarayan, Barnaby R. Scholefield and Elizabeth S. Draper

    Citation: Critical Care 2021 25:399

    Content type: Research

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  10. We assessed the prognostic accuracy of the standardized electroencephalography (EEG) patterns (“highly malignant,” “malignant,” and “benign”) according to the EEG timing (early vs. late) and investigated the E...

    Authors: Youn-Jung Kim, Min-Jee Kim, Yong Hwan Kim, Chun Song Youn, In Soo Cho, Su Jin Kim, Jung Hee Wee, Yoo Seok Park, Joo Suk Oh, Dong Hoon Lee and Won Young Kim

    Citation: Critical Care 2021 25:398

    Content type: Research

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  11. Authors: Jean-Louis Vincent, Mervyn Singer, Sharon Einav, Rui Moreno, Julia Wendon, Jean-Louis Teboul, Jan Bakker, Glenn Hernandez, Djillali Annane, Angélique M. E. de Man, Xavier Monnet, V. Marco Ranieri, Olfa Hamzaoui, Jukka Takala, Nicole Juffermans, Jean-Daniel Chiche…

    Citation: Critical Care 2021 25:397

    Content type: Editorial

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  12. Authors: William Xu, Armen A. Gharibans, Ian P. Bissett, Gregory O’Grady, Cameron I. Wells, Carlos Areia, Christopher Biggs, Mauro Santos, Neal Thurley, Stephen Gerry, Lionel Tarassenko, Peter Watkinson and Sarah Vollam

    Citation: Critical Care 2021 25:394

    Content type: Letter

    Published on:

    The original article was published in Critical Care 2021 25:351

  13. Prognostic assessments of the mortality of critically ill patients are frequently performed in daily clinical practice and provide prognostic guidance in treatment decisions. In contrast to several sophisticat...

    Authors: Eline G. M. Cox, Marisa Onrust, Madelon E. Vos, Wolter Paans, Willem Dieperink, Jacqueline Koeze, Iwan C. C. van der Horst and Renske Wiersema

    Citation: Critical Care 2021 25:393

    Content type: Research

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  14. Enrollment problems are common among randomized controlled trials conducted in the ICU. However, little is known about actual trial enrollment rates and influential factors. We set out to determine the overall...

    Authors: Dustin C. Krutsinger, Kuldeep N. Yadav, Michael O. Harhay, Karsten Bartels and Katherine R. Courtright

    Citation: Critical Care 2021 25:392

    Content type: Research

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  15. Extubation failure is an important issue in ventilated patients and its risk factors remain a matter of research. We conducted a systematic review and meta-analysis to explore factors associated with extubatio...

    Authors: Flavia Torrini, Ségolène Gendreau, Johanna Morel, Guillaume Carteaux, Arnaud W. Thille, Massimo Antonelli and Armand Mekontso Dessap

    Citation: Critical Care 2021 25:391

    Content type: Research

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  16. Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by lung inflammation and pulmonary edema. Coronavirus disease 2019 (COVID-19) is associated with ARDS in the more sever...

    Authors: Jose Angel Lorente, Nicolas Nin, Palmira Villa, Dovami Vasco, Ana B. Miguel-Coello, Ignacio Rodriguez, Raquel Herrero, Oscar Peñuelas, Jesús Ruiz-Cabello and Jose L. Izquierdo-Garcia

    Citation: Critical Care 2021 25:390

    Content type: Research

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  17. Timely recognition of hemodynamic instability in critically ill patients enables increased vigilance and early treatment opportunities. We develop the Hemodynamic Stability Index (HSI), which highlights situat...

    Authors: Asif Rahman, Yale Chang, Junzi Dong, Bryan Conroy, Annamalai Natarajan, Takahiro Kinoshita, Francesco Vicario, Joseph Frassica and Minnan Xu-Wilson

    Citation: Critical Care 2021 25:388

    Content type: Research

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  18. Extracorporeal cardiopulmonary resuscitation (E-CPR) is used for the treatment of refractory cardiac arrest. However, the optimal target to reach for mean arterial pressure (MAP) remains to be determined. We h...

    Authors: Yael Levy, Alice Hutin, Fanny Lidouren, Nicolas Polge, Rocio Fernandez, Matthias Kohlhauer, Pierre-Louis Leger, Guillaume Debaty, Keith Lurie, Lionel Lamhaut, Bijan Ghaleh and Renaud Tissier

    Citation: Critical Care 2021 25:369

    Content type: Research

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  19. There are few reports of new functional impairment following critical illness from COVID-19. We aimed to describe the incidence of death or new disability, functional impairment and changes in health-related q...

    Authors: Carol L. Hodgson, Alisa M. Higgins, Michael J. Bailey, Anne M. Mather, Lisa Beach, Rinaldo Bellomo, Bernie Bissett, Ianthe J. Boden, Scott Bradley, Aidan Burrell, D. James Cooper, Bentley J. Fulcher, Kimberley J. Haines, Jack Hopkins, Alice Y. M. Jones, Stuart Lane…

    Citation: Critical Care 2021 25:382

    Content type: Research

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  20. COVID-19 is primarily a respiratory disease; however, there is also evidence that it causes endothelial damage in the microvasculature of several organs. The aim of the present study is to characterize in vivo...

    Authors: Jaume Mesquida, A. Caballer, L. Cortese, C. Vila, U. Karadeniz, M. Pagliazzi, M. Zanoletti, A. Pérez Pacheco, P. Castro, M. García-de-Acilu, R. C. Mesquita, D. R. Busch and T. Durduran

    Citation: Critical Care 2021 25:381

    Content type: Research

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  21. Tranexamic acid (TXA) reduces surgical bleeding and reduces death from bleeding after trauma and childbirth. However, its effects on thrombotic events and seizures are less clear. We conducted a systematic rev...

    Authors: Shuhei Murao, Hidekazu Nakata, Ian Roberts and Kazuma Yamakawa

    Citation: Critical Care 2021 25:380

    Content type: Research

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  22. A high body mass index (BMI) has been associated with decreased mortality in critically ill patients. This association may, in part, relate to the impact of BMI on glycemia. We aimed to study the relationship ...

    Authors: Drago Plečko, Nicolas Bennett, Johan Mårtensson and Rinaldo Bellomo

    Citation: Critical Care 2021 25:378

    Content type: Research

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  23. Experimental studies of head-up positioning (HUP) during cardiopulmonary resuscitation (CPR) have had some degree of conflicting published results. The current study aim was to analyze and reconcile those disc...

    Authors: Cheng-Chieh Huang, Kuan-Chih Chen, Zih-Yang Lin, Yu-Hsuan Chou, Wen-Liang Chen, Tsung-Han Lee, Kun-Te Lin, Pei-You Hsieh, Cheng Hsu Chen, Chu-Chung Chou and Yan-Ren Lin

    Citation: Critical Care 2021 25:376

    Content type: Research

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  24. Recent evidence suggests a potentially protective effect of increasing ketone body availability via accepting low macronutrient intake early after onset of critical illness. The impact of blood glucose control...

    Authors: Jan Gunst, Astrid De Bruyn, Michael P. Casaer, Sarah Vander Perre, Lies Langouche and Greet Van den Berghe

    Citation: Critical Care 2021 25:373

    Content type: Research

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  25. Drowning is a global threat and one of the leading causes of injury around the world. The impact of drowning conditions including water salinity on patients’ prognosis remains poorly explored in Intensive Care...

    Authors: Florian Reizine, Agathe Delbove, Alexandre Dos Santos, Laetitia Bodenes, Pierre Bouju, Pierre Fillâtre, Aurélien Frérou, Guillaume Halley, Olivier Lesieur, Maud Jonas, Florian Berteau, Jean Morin, David Luque-Paz, Rémy Marnai, Anthony Le Meur, Cécile Aubron…

    Citation: Critical Care 2021 25:372

    Content type: Research

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  26. Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates.

    Authors: Daniel O. Thomas-Rüddel, Peter Hoffmann, Daniel Schwarzkopf, Christian Scheer, Friedhelm Bach, Marcus Komann, Herwig Gerlach, Manfred Weiss, Matthias Lindner, Hendrik Rüddel, Philipp Simon, Sven-Olaf Kuhn, Reinhard Wetzker, Michael Bauer, Konrad Reinhart and Frank Bloos

    Citation: Critical Care 2021 25:368

    Content type: Research

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  27. The large, international, randomized controlled NeoPInS trial showed that procalcitonin (PCT)-guided decision making was superior to standard care in reducing the duration of antibiotic therapy and hospitaliza...

    Authors: A. J. L. M. Geraerds, Wendy van Herk, Martin Stocker, Salhab el Helou, Sourabh Dutta, Matteo S. Fontana, Frank A. B. A. Schuerman, Rita K. van den Tooren-de Groot, Jantien Wieringa, Jan Janota, Laura H. van der Meer-Kappelle, Rob Moonen, Sintha D. Sie, Esther de Vries, Albertine E. Donker, Urs Zimmerman…

    Citation: Critical Care 2021 25:367

    Content type: Research

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  28. Authors: Natsuko Kaku, Yu Nakagama, Michinori Shirano, Sari Shinomiya, Kazuhiro Shimazu, Katsuaki Yamazaki, Yoshito Maehata, Ryo Morita, Yuko Nitahara, Hiromasa Yamamoto, Yasumitsu Mizobata and Yasutoshi Kido

    Citation: Critical Care 2021 25:366

    Content type: Letter

    Published on:

    The original article was published in Critical Care 2021 25:248

  29. Timing of swallows in relation to respiratory phases is associated with aspiration events. Oxygen therapy possibly affects the timing of swallows, which may alter airway protective mechanisms.

    Authors: Pornpan Rattanajiajaroen and Napplika Kongpolprom

    Citation: Critical Care 2021 25:365

    Content type: Research

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