From: Cytomegalovirus reactivation and associated outcome of critically ill patients with severe sepsis
 | Univariable analysis | Multivariable analysis | |||
---|---|---|---|---|---|
Factor | HR | P-v alue | HR | 95% CI | P-v alue |
CMV reactivation | 0.410 | 0.029 | 0.369 | 0.136 to 1.005 | 0.051 |
SAPS II at inclusion | 1.062 | <0.001 | 1.047 | 1.012 to 1.082 | 0.008 |
Septic Shock present | 2.193 | 0.081 | 1.470 | 0.555 to 3.896 | 0.438 |
ICU stay before enrolment | 1.010 | 0.298 | 1.022 | 0.999 to 1.046 | 0.058 |
HSV detection in respiratory secretions | 1.539 | 0.268 | 1.546 | 0.687 to 3.480 | 0.292 |
Optimized model | |||||
CMV reactivation | Â | Â | 0.496 | 0.215 to 1.145 | 0.101 |
SAPS II at inclusion | Â | Â | 1.056 | 1.024 to 1.089 | <0.001 |
Landmark analysis for Day 0, Day 7 and Day 14 | |||||
Day 0 (86 patients, 12 of them with CMV reactivation) | |||||
   CMV reactivation | 0.983 | 0.974 | 1.005 | 0.347 to 2.911 | 0.993 |
   SAPS II at inclusion | 1.062 | <0.001 | 1.062 | 1.030 to 1.096 | <0.001 |
Day 7 (75 patients, 18 of them with CMV reactivation) | |||||
   CMV reactivation | 0.559 | 0.259 | 0.486 | 0.173 to 1.370 | 0.172 |
   SAPS II at inclusion | 1.063 | 0.001 | 1.064 | 1.027 to 1.102 | <0.001 |
Day 14 (62 patients, 20 of them with CMV reactivation) | |||||
   CMV reactivation | 0.707 | 0.492 | 0.561 | 0.204 to 1.544 | 0.263 |
   SAPS II at inclusion | 1.065 | 0.003 | 1.067 | 1.026 to 1.111 | 0.001 |