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Citation: Critical Care 2024 28(Suppl 1):68
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A comparison of extracorporeal and conventional cardiopulmonary resuscitation for cardiac arrest
Citation: Critical Care 2024 28:86 -
The incidences of acute mesenteric ischaemia vary greatly depending on the population and diagnostic activity
Citation: Critical Care 2024 28:85 -
Trauma systems in high socioeconomic index countries in 2050
Considerable political, structural, environmental and epidemiological change will affect high socioeconomic index (SDI) countries over the next 25 years. These changes will impact healthcare provision and cons...
Citation: Critical Care 2024 28:84 -
The elusive relationship between cardiac filling and fluid responsiveness
Citation: Critical Care 2024 28:83 -
Effects of prone positioning on lung mechanical power components in patients with acute respiratory distress syndrome: a physiologic study
Prone positioning (PP) homogenizes ventilation distribution and may limit ventilator-induced lung injury (VILI) in patients with moderate to severe acute respiratory distress syndrome (ARDS). The static and dy...
Citation: Critical Care 2024 28:82 -
Trends in pre-hospital volume resuscitation of blunt trauma patients: a 15-year analysis of the British (TARN) and German (TraumaRegister DGU®) National Registries
Fluid resuscitation has long been a cornerstone of pre-hospital trauma care, yet its optimal approach remains undetermined. Although a liberal approach to fluid resuscitation has been linked with increased com...
Citation: Critical Care 2024 28:81 -
Scrutinizing mechanical circulatory support in cardiogenic shock: Have we jumped the gun?
Despite increasing therapeutic options and disposable resources, cardiogenic shock (CS) remains a formidable condition with high mortality. Today, veno-arterial extracorporeal membrane oxygenation and microaxi...
Citation: Critical Care 2024 28:80 -
Albumin for sepsis-related peripheral tissue hypoperfusion
Citation: Critical Care 2024 28:79 -
Prognostic value of near-infrared spectroscopy regional oxygen saturation and cerebrovascular reactivity index in acute traumatic neural injury: a CAnadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Cohort Study
Near-infrared spectroscopy regional cerebral oxygen saturation (rSO2) has gained interest as a raw parameter and as a basis for measuring cerebrovascular reactivity (CVR) due to its noninvasive nature and high sp...
Citation: Critical Care 2024 28:78 -
Impact of COVID-19 on posttraumatic stress disorder in ICU survivors: a prospective observational comparative cohort study
Posttraumatic stress disorder (PTSD) after a stay in the intensive care unit (ICU) can affect one in five ICU survivors. At the beginning of the coronavirus disease 2019 (COVID-19) pandemic, admission to the I...
Citation: Critical Care 2024 28:77 -
Real-time machine learning model to predict short-term mortality in critically ill patients: development and international validation
A real-time model for predicting short-term mortality in critically ill patients is needed to identify patients at imminent risk. However, the performance of the model needs to be validated in various clinical...
Citation: Critical Care 2024 28:76 -
Flow starvation during square-flow assisted ventilation detected by supervised deep learning techniques
Flow starvation is a type of patient-ventilator asynchrony that occurs when gas delivery does not fully meet the patients’ ventilatory demand due to an insufficient airflow and/or a high inspiratory effort, an...
Citation: Critical Care 2024 28:75 -
Mean arterial pressure during cardiopulmonary bypass: A modifiable risk factor for acute kidney injury in cardiac surgery patients?
Citation: Critical Care 2024 28:74 -
Transitions of blood immune endotypes and improved outcome by anakinra in COVID-19 pneumonia: an analysis of the SAVE-MORE randomized controlled trial
Endotype classification may guide immunomodulatory management of patients with bacterial and viral sepsis. We aimed to identify immune endotypes and transitions associated with response to anakinra (human inte...
Citation: Critical Care 2024 28:73 -
Long-term outcome in new onset refractory status epilepticus: a retrospective study
New onset refractory status epilepticus (NORSE) is a neurologic emergency without an immediately identifiable cause. The complicated and long ICU stay of the patients can lead to perceiving a prolongation of t...
Citation: Critical Care 2024 28:72 -
Pathophysiology of acute lung injury in patients with acute brain injury: the triple-hit hypothesis
It has been convincingly demonstrated in recent years that isolated acute brain injury (ABI) may cause severe dysfunction of peripheral extracranial organs and systems. Of all potential target organs and syste...
Citation: Critical Care 2024 28:71 -
Accuracy of respiratory muscle assessments to predict weaning outcomes: a systematic review and comparative meta-analysis
Several bedside assessments are used to evaluate respiratory muscle function and to predict weaning from mechanical ventilation in patients on the intensive care unit. It remains unclear which assessments perf...
Citation: Critical Care 2024 28:70 -
Toxicities, intensive care management, and outcome of chimeric antigen receptor T cells in adults: an update
Chimeric antigen receptor T cells are a promising new immunotherapy for haematological malignancies. Six CAR-T cells products are currently available for adult patients with refractory or relapsed high-grade B...
Citation: Critical Care 2024 28:69 -
The acute mesenteric ischaemia (AMESI) study: a matter of incidence
Citation: Critical Care 2024 28:67 -
Impact of hyperoxia on the gut during critical illnesses
Molecular oxygen is typically delivered to patients via oxygen inhalation or extracorporeal membrane oxygenation (ECMO), potentially resulting in systemic hyperoxia from liberal oxygen inhalation or localized ...
Citation: Critical Care 2024 28:66 -
Imatinib treatment improves hyperglycaemic dysregulation in severe COVID-19: a secondary analysis of blood biomarkers in a randomised controlled trial
SARS-CoV-2 can induce insulin resistance, which is, among others, mediated by adipose tissue dysfunction and reduced angiotensin-converting enzyme 2 (ACE2) enzymatic activity. In SARS-CoV-2-infected mice, the ...
Citation: Critical Care 2024 28:65 -
Prevention of post-operative delirium using an overnight infusion of dexmedetomidine in patients undergoing cardiac surgery: a pragmatic, randomized, double-blind, placebo-controlled trial
After cardiac surgery, post-operative delirium (PoD) is acknowledged to have a significant negative impact on patient outcome. To date, there is no valuable and specific treatment for PoD. Critically ill patie...
Citation: Critical Care 2024 28:64 -
Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia
Acute respiratory distress syndrome (ARDS) is a life-threatening critical care syndrome commonly associated with infections such as COVID-19, influenza, and bacterial pneumonia. Ongoing research aims to improv...
Citation: Critical Care 2024 28:63 -
The use of mechanical CPR for IHCA during the COVID-19 pandemic as compared to the pre-pandemic period
Citation: Critical Care 2024 28:62 -
Violence against healthcare professionals in intensive care units: a systematic review and meta-analysis of frequency, risk factors, interventions, and preventive measures
To assess the frequency, risk factors, consequences, and prevention of violence against healthcare workers in intensive care units.
Citation: Critical Care 2024 28:61 -
How often do we need to update PEEP setting during prone positioning in ARDS?
Citation: Critical Care 2024 28:60 -
Reflections on epidemiological investigations of sepsis in the Asian Region
Citation: Critical Care 2024 28:59 -
Improving management of ARDS: uniting acute management and long-term recovery
Acute Respiratory Distress Syndrome (ARDS) is an important global health issue with high in-hospital mortality. Importantly, the impact of ARDS extends beyond the acute phase, with increased mortality and disa...
Citation: Critical Care 2024 28:58 -
Extracorporeal cardiopulmonary resuscitation versus conventional CPR in cardiac arrest: an updated meta-analysis and trial sequential analysis
Extracorporeal cardiopulmonary resuscitation (ECPR) may reduce mortality and improve neurological outcomes in patients with cardiac arrest. We updated our existing meta-analysis and trial sequential analysis t...
Citation: Critical Care 2024 28:57 -
Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial
Despite evidence associating inflammatory biomarkers with worse outcomes in hospitalized adults with COVID-19, trials of immunomodulatory therapies have met with mixed results, likely due in part to biological...
Citation: Critical Care 2024 28:56 -
Evidence supports the use of hydrocortisone for patients with community-acquired pneumonia
Citation: Critical Care 2024 28:55 -
Healthcare-associated infections in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study
Both critically ill patients with coronavirus disease 2019 (COVID-19) and patients receiving extracorporeal membrane oxygenation (ECMO) support exhibit a high incidence of healthcare-associated infections (HAI...
Citation: Critical Care 2024 28:54 -
Cardiogenic shock: all hail the RCT, long live the registry
Citation: Critical Care 2024 28:53 -
Coexistence of a fluid responsive state and venous congestion signals in critically ill patients: a multicenter observational proof-of-concept study
Current recommendations support guiding fluid resuscitation through the assessment of fluid responsiveness. Recently, the concept of fluid tolerance and the prevention of venous congestion (VC) have emerged as...
Citation: Critical Care 2024 28:52 -
The administration of four-factor prothrombin complex concentrate exacerbates thrombin generation in trauma patients at risk of massive transfusion: an ancillary study of the PROCOAG trial
Citation: Critical Care 2024 28:51 -
Phenotype-specific therapeutic efficacy of ilofotase alfa in patients with sepsis-associated acute kidney injury
There is no effective treatment for sepsis-associated acute kidney injury (SA-AKI). Ilofotase alfa (human recombinant alkaline phosphatase) has been shown to exert reno-protective properties, although it remai...
Citation: Critical Care 2024 28:50 -
Understanding the nebulisation of antibiotics: the key role of lung microdialysis studies
Nebulisation of antibiotics is a promising treatment for ventilator-associated pneumonia (VAP) caused by multidrug-resistant organisms. Ensuring effective antibiotic concentrations at the site of infection in ...
Citation: Critical Care 2024 28:49 -
Ketamine versus etomidate as an induction agent for tracheal intubation in critically ill adults: a Bayesian meta-analysis
Tracheal intubation is a high-risk intervention commonly performed in critically ill patients. Due to its favorable cardiovascular profile, ketamine is considered less likely to compromise clinical outcomes. T...
Citation: Critical Care 2024 28:48 -
Trauma systems in Asian countries: challenges and recommendations
Trauma burden is one of the leading causes of young human life and economic loss in low- and middle-income countries. Improved emergency and trauma care systems may save up to 2 million lives in these countries.
Citation: Critical Care 2024 28:47 -
Administration of methylene blue in septic shock: pros and cons
Septic shock typically requires the administration of vasopressors. Adrenergic agents remain the first choice, namely norepinephrine. However, their use to counteract life-threatening hypotension comes with po...
Citation: Critical Care 2024 28:46 -
Transforming research to improve therapies for trauma in the twenty-first century
Improvements have been made in optimizing initial care of trauma patients, both in prehospital systems as well as in the emergency department, and these have also favorably affected longer term outcomes. Howev...
Citation: Critical Care 2024 28:45 -
Procalcitonin for the diagnosis of postoperative bacterial infection after adult cardiac surgery: a systematic review and meta-analysis
Patients undergoing cardiac surgery are subject to infectious complications that adversely affect outcomes. Rapid identification is essential for adequate treatment. Procalcitonin (PCT) is a noninvasive blood ...
Citation: Critical Care 2024 28:44 -
Albumin versus saline infusion for sepsis-related peripheral tissue hypoperfusion: a proof-of-concept prospective study
Albumin has potential endothelial protective effects through antioxidant and anti-inflammatory properties. However, the effect of albumin on peripheral tissue perfusion in human sepsis remains poorly known.
Citation: Critical Care 2024 28:43 -
qSOFA combined with suPAR for early risk detection and guidance of antibiotic treatment in the emergency department: a randomized controlled trial
Sepsis guidelines suggest immediate start of resuscitation for patients with quick Sequential Organ Failure Assessment (qSOFA) 2 or 3. However, the interpretation of qSOFA 1 remains controversial. We investiga...
Citation: Critical Care 2024 28:42 -
Thiamine administration in septic shock: a post hoc analysis of two randomized trials
This is a post hoc analysis of combined cohorts from two previous Phase II clinical trials to assess the effect of thiamine administration on kidney protection and mortality in patients with septic shock.
Citation: Critical Care 2024 28:41 -
Antibiotic definitive treatment in ventilator associated pneumonia caused by AmpC-producing Enterobacterales in critically ill patients: a prospective multicenter observational study
Ventilator associated pneumonia (VAP) due to wild-type AmpC-producing Enterobacterales (wtAE) is frequent in intensive care unit (ICU) patients. Despite a low level of evidence, definitive antimicrobial therap...
Citation: Critical Care 2024 28:40 -
Blood volume and hemodynamics during treatment of major hemorrhage with Ringer solution, 5% albumin, and 20% albumin: a single-center randomized controlled trial
Volume replacement with crystalloid fluid is the conventional treatment of hemorrhage. We challenged whether a standardized amount of 5% or 20% albumin could be a viable option to maintain the blood volume dur...
Citation: Critical Care 2024 28:39 -
Combining proteins with n-3 PUFAs (EPA + DHA) and their inflammation pro-resolution mediators for preservation of skeletal muscle mass
The optimal feeding strategy for critically ill patients is still debated, but feeding must be adapted to individual patient needs. Critically ill patients are at risk of muscle catabolism, leading to loss of ...
Citation: Critical Care 2024 28:38 -
Response to: the association between time definition of reintubation and patient outcomes in critically ill patients—several topics should be noticed
Citation: Critical Care 2024 28:37
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- ISSN: 1364-8535 (electronic)