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  1. Tidal expiratory flow limitation (EFLT) complicates the delivery of mechanical ventilation but is only diagnosed by performing specific manoeuvres. Instantaneous analysis of expiratory resistance (Rex) can be an ...

    Authors: Detajin Junhasavasdikul, Akarawut Kasemchaiyanun, Tanakorn Tassaneyasin, Tananchai Petnak, Frank Silva Bezerra, Ricard Mellado‐Artigas, Lu Chen, Yuda Sutherasan, Pongdhep Theerawit and Laurent Brochard
    Citation: Critical Care 2024 28:171
  2. The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and in patients with moderate TBI who deteriorate and r...

    Authors: Andrea Lavinio, Jonathan P. Coles, Chiara Robba, Marcel Aries, Pierre Bouzat, Dara Chean, Shirin Frisvold, Laura Galarza, Raimund Helbok, Jeroen Hermanides, Mathieu van der Jagt, David K. Menon, Geert Meyfroidt, Jean-Francois Payen, Daniele Poole, Frank Rasulo…
    Citation: Critical Care 2024 28:170
  3. Acute kidney injury (AKI) is a significant risk factor associated with reduced survival following out-of-hospital cardiac arrest (OHCA). Whether the severity of AKI simply serves as a surrogate measure of wors...

    Authors: Karoline Korsholm Jeppesen, Sebastian Buhl Rasmussen, Jesper Kjaergaard, Henrik Schmidt, Simon Mølstrøm, Rasmus Paulin Beske, Johannes Grand, Hanne Berg Ravn, Matilde Winther-Jensen, Martin Abild Stengaard Meyer, Christian Hassager and Jacob Eifer Møller
    Citation: Critical Care 2024 28:169
  4. Critically injured patients need rapid and appropriate hemostatic treatment, which requires prompt identification of trauma-induced coagulopathy (TIC) upon hospital admission. We developed and validated the pe...

    Authors: Louis Brac, Albrice Levrat, Charles-Hervé Vacheron, Pierre Bouzat, Tristan Delory and Jean-Stéphane David
    Citation: Critical Care 2024 28:168
  5. Non-resuscitation fluids constitute the majority of fluid administered for septic shock patients in the intensive care unit (ICU). This multicentre, randomized, feasibility trial was conducted to test the hypo...

    Authors: Anja Lindén, M. Spångfors, M. H. Olsen, J. Fisher, G. Lilja, F. Sjövall, M. Jungner, M. Lengquist, T. Kander, L. Samuelsson, J. Johansson, E. Palmnäs, J. Undén, J. Oras, M. Cronhjort, M. Chew…
    Citation: Critical Care 2024 28:166
  6. Mechanical ventilation, a lifesaving intervention in critical care, can lead to damage in the extracellular matrix (ECM), triggering inflammation and ventilator-induced lung injury (VILI), particularly in cond...

    Authors: Lou’i Al-Husinat, Saif Azzam, Sarah Al Sharie, Ahmed H. Al Sharie, Denise Battaglini, Chiara Robba, John J. Marini, Lauren T. Thornton, Fernanda F. Cruz, Pedro L. Silva and Patricia R. M. Rocco
    Citation: Critical Care 2024 28:165
  7. Hypoinflammatory and hyperinflammatory phenotypes have been identified in both Acute Respiratory Distress Syndrome (ARDS) and sepsis. Attributable mortality of ARDS in each phenotype of sepsis is yet to be det...

    Authors: Bruno Evrard, Pratik Sinha, Kevin Delucchi, Carolyn M. Hendrickson, Kirsten N. Kangelaris, Kathleen D. Liu, Andrew Willmore, Nelson Wu, Lucile Neyton, Emma Schmiege, Antonio Gomez, V. Eric Kerchberger, Ann Zalucky, Michael A. Matthay, Lorraine B. Ware and Carolyn S. Calfee
    Citation: Critical Care 2024 28:164
  8. Signal complexity (i.e. entropy) describes the level of order within a system. Low physiological signal complexity predicts unfavorable outcome in a variety of diseases and is assumed to reflect increased rigi...

    Authors: Stefan Yu Bögli, Ihsane Olakorede, Michael Veldeman, Erta Beqiri, Miriam Weiss, Gerrit Alexander Schubert, Jan Folkard Willms, Emanuela Keller and Peter Smielewski
    Citation: Critical Care 2024 28:163
  9. The effect of the periurethral cleansing range on catheter-associated urinary tract infection (CAUTI) occurrence remains unknown. The purpose of this study was to evaluate the efficacy of expanded periurethral...

    Authors: Xingsong Qin, He Zhao, Wei Qin, Xinglei Qin, Songying Shen and Hongyu Wang
    Citation: Critical Care 2024 28:162
  10. Limited data are available on organ donation practices and recipient outcomes, particularly when comparing donors who experienced cardiac arrest and received extracorporeal cardiopulmonary resuscitation (ECPR)...

    Authors: Tetsuya Yumoto, Kohei Tsukahara, Takafumi Obara, Takashi Hongo, Tsuyoshi Nojima, Hiromichi Naito and Atsunori Nakao
    Citation: Critical Care 2024 28:160
  11. An increasing number of patients requires extracorporeal membrane oxygenation (ECMO) for life support. This supportive modality is associated with nosocomial infections (NIs). This systematic review and meta-a...

    Authors: Ali Ait Hssain, Amir Vahedian-Azimi, Abdulsalam Saif Ibrahim, Ibrahim Fawzy Hassan, Elie Azoulay and Michael Darmon
    Citation: Critical Care 2024 28:158
  12. Invasive ventilation is a fundamental treatment in intensive care but its precise timing is difficult to determine. This study aims at assessing the effect of initiating invasive ventilation versus waiting, in...

    Authors: Ricard Mellado-Artigas, Xavier Borrat, Bruno L. Ferreyro, Christopher Yarnell, Sicheng Hao, Kerollos N. Wanis, Enric Barbeta, Antoni Torres, Carlos Ferrando and Laurent Brochard
    Citation: Critical Care 2024 28:157
  13. Current classification for acute kidney injury (AKI) in critically ill patients with sepsis relies only on its severity-measured by maximum creatinine which overlooks inherent complexities and longitudinal eva...

    Authors: Kullaya Takkavatakarn, Wonsuk Oh, Lili Chan, Ira Hofer, Khaled Shawwa, Monica Kraft, Neomi Shah, Roopa Kohli-Seth, Girish N. Nadkarni and Ankit Sakhuja
    Citation: Critical Care 2024 28:156
  14. Healthcare systems are large contributors to global emissions, and intensive care units (ICUs) are a complex and resource-intensive component of these systems. Recent global movements in sustainability initiat...

    Authors: Faisal N. Masud, Farzan Sasangohar, Iqbal Ratnani, Sahar Fatima, Marco Antonio Hernandez, Teal Riley, Jason Fischer, Atiya Dhala, Megan E. Gooch, Konya Keeling-Johnson, Jukrin Moon and Jean-Louis Vincent
    Citation: Critical Care 2024 28:154
  15. Re-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to con...

    Authors: Tommaso Pettenuzzo, Annalisa Boscolo, Elisa Pistollato, Chiara Pretto, Tommaso Antonio Giacon, Sara Frasson, Francesco Maria Carbotti, Francesca Medici, Giovanni Pettenon, Giuliana Carofiglio, Marco Nardelli, Nicolas Cucci, Clara Letizia Tuccio, Veronica Gagliardi, Chiara Schiavolin, Caterina Simoni…
    Citation: Critical Care 2024 28:152
  16. Intensive care unit (ICU)-survivors have an increased risk of mortality after discharge compared to the general population. On ICU admission subphenotypes based on the plasma biomarker levels of interleukin-8,...

    Authors: Marleen A. Slim, Rombout B. E. van Amstel, Lieuwe D. J. Bos, Olaf L. Cremer, W. Joost Wiersinga, Tom van der Poll and Lonneke A. van Vught
    Citation: Critical Care 2024 28:151
  17. Prior assessments of critical care outcomes in patients with cirrhosis have shown conflicting results. We aimed to provide nationwide generalizable results of critical care outcomes in patients with decompensa...

    Authors: Spencer R. Goble, Abdellatif S. Ismail, Jose D. Debes and Thomas M. Leventhal
    Citation: Critical Care 2024 28:150
  18. Sepsis occurs in 12–27% of patients with haematological malignancy within a year of diagnosis. Sepsis mortality has improved in non-cancer patients in the last two decades, but longitudinal trends in patients ...

    Authors: Aleece MacPhail, Claire Dendle, Monica Slavin, Robert Weinkove, Michael Bailey, David Pilcher and Zoe McQuilten
    Citation: Critical Care 2024 28:148
  19. A systematic review and meta-analysis to evaluate the impact of extracorporeal carbon dioxide removal (ECCO2R) on gas exchange and respiratory settings in critically ill adults with respiratory failure.

    Authors: Alexandra-Maria Stommel, Harald Herkner, Calvin Lukas Kienbacher, Brigitte Wildner, Alexander Hermann and Thomas Staudinger
    Citation: Critical Care 2024 28:146
  20. Screening for hazardous alcohol use and performing brief interventions (BIs) are recommended to reduce alcohol-related negative health consequences. We aimed to compare the effectiveness (defined as an at leas...

    Authors: Eliisa Nissilä, Marja Hynninen, Ville Jalkanen, Anne Kuitunen, Minna Bäcklund, Outi Inkinen and Johanna Hästbacka
    Citation: Critical Care 2024 28:145
  21. Physical rehabilitation of critically ill patients is implemented to improve physical outcomes from an intensive care stay. However, before rehabilitation is implemented, a risk assessment is essential, based ...

    Authors: Huw R. Woodbridge, Christopher J. McCarthy, Mandy Jones, Matthew Willis, David B. Antcliffe, Caroline M. Alexander and Anthony C. Gordon
    Citation: Critical Care 2024 28:144
  22. To determine whether intermittent intravenous (IV) paracetamol as primary analgesic would significantly reduce morphine consumption in children aged 0–3 years after cardiac surgery with cardiopulmonary bypass.

    Authors: Gerdien Zeilmaker-Roest, Christine de Vries-Rink, Joost van Rosmalen, Monique van Dijk, Saskia N. de Wildt, Catherijne A. J. Knibbe, Erik Koomen, Nicolaas J. G. Jansen, Martin C. J. Kneyber, Sofie Maebe, Greet Van den Berghe, Renata Haghedooren, Dirk Vlasselaers, Ad J. J. C. Bogers, Dick Tibboel and Enno D. Wildschut
    Citation: Critical Care 2024 28:143
  23. End-expiratory lung volume (EELV) is reduced in mechanically ventilated patients, especially in pathologic conditions. The resulting heterogeneous distribution of ventilation increases the risk for ventilation...

    Authors: J. A. Sanchez Giralt, G. Tusman, M. Wallin, M. Hallback, A. Perez Lucendo, M. Sanchez Galindo, B. Abad Santamaria, E. Paz Calzada, P. Garcia Garcia, D. Rodriguez Huerta, A. Canabal Berlanga and Fernando Suarez-Sipmann
    Citation: Critical Care 2024 28:142
  24. Clinicians currently monitor pressure and volume at the airway opening, assuming that these observations relate closely to stresses and strains at the micro level. Indeed, this assumption forms the basis of cu...

    Authors: John J. Marini, Patricia R. M. Rocco, Lauren T. Thornton and Philip S. Crooke
    Citation: Critical Care 2024 28:141
  25. This study aimed to validate apparent diffusion coefficient (ADC) values and thresholds to predict poor neurological outcomes in out-of-hospital cardiac arrest (OHCA) survivors by quantitatively analysing the ...

    Authors: Jung A Yoon, Changshin Kang, Jung Soo Park, Yeonho You, Jin Hong Min, Yong Nam In, Wonjoon Jeong, Hong Jun Ahn, Hye Seon Jeong, Yong Hwan Kim, Byung Kook Lee and Dongha Kim
    Citation: Critical Care 2024 28:138
  26. In acute respiratory distress syndrome (ARDS), respiratory drive often differs among patients with similar clinical characteristics. Readily observable factors like acid–base state, oxygenation, mechanics, and...

    Authors: Elias Baedorf-Kassis, Michael Murn, Amy L. Dzierba, Alexis L. Serra, Ivan Garcia, Emily Minus, Clarissa Padilla, Todd Sarge, Valerie M. Goodspeed, Michael A. Matthay, Michelle N. Gong, Deborah Cook, Stephen H. Loring, Daniel Talmor and Jeremy R. Beitler
    Citation: Critical Care 2024 28:136
  27. In this study, the concentrations of inflammatory cytokines were measured in the bronchial epithelial lining fluid (ELF) and plasma in patients with acute hypoxemic respiratory failure (AHRF) secondary to seve...

    Authors: Kazuki Sudo, Mao Kinoshita, Ken Kawaguchi, Kohsuke Kushimoto, Ryogo Yoshii, Keita Inoue, Masaki Yamasaki, Tasuku Matsuyama, Kunihiko Kooguchi, Yasuo Takashima, Masami Tanaka, Kazumichi Matsumoto, Kei Tashiro, Tohru Inaba, Bon Ohta and Teiji Sawa
    Citation: Critical Care 2024 28:134
  28. Acute respiratory distress syndrome (ARDS) is responsible for 400,000 deaths annually worldwide. Few improvements have been made despite five decades of research, partially because ARDS is a highly heterogeneo...

    Authors: Sébastien Imbert, Mathilde Revers, Raphaël Enaud, Arthur Orieux, Adrian Camino, Alexandre Massri, Laurent Villeneuve, Cédric Carrié, Laurent Petit, Alexandre Boyer, Patrick Berger, Didier Gruson, Laurence Delhaes and Renaud Prével
    Citation: Critical Care 2024 28:133

    The Matters Arising to this article has been published in Critical Care 2024 28:147

  29. Rapidly improving acute respiratory distress syndrome (RIARDS) is an increasingly appreciated subgroup of ARDS in which hypoxemia improves within 24 h after initiation of mechanical ventilation. Detailed clini...

    Authors: Patricia L. Valda Toro, Andrew Willmore, Nelson E. Wu, Kevin L. Delucchi, Alejandra Jauregui, Pratik Sinha, Kathleen D. Liu, Carolyn M. Hendrickson, Aartik Sarma, Lucile P. A. Neyton, Aleksandra Leligdowicz, Charles R. Langelier, Hanjing Zhuo, Chayse Jones, Kirsten N. Kangelaris, Antonio D. Gomez…
    Citation: Critical Care 2024 28:132
  30. Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring mechanical ventilation suffer from a high incidence of ventilator associated pneumonia (VAP), mainly relate...

    Authors: Keyvan Razazi, Charles-Edouard Luyt, Guillaume Voiriot, Anahita Rouzé, Marc Garnier, Alexis Ferré, Laurent Camous, Nicholas Heming, Nathanaël Lapidus, Anais Charles-Nelson and Armand Mekontso-Dessap
    Citation: Critical Care 2024 28:131
  31. Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARB) medications are widely prescribed. We sought to assess how pre-admission use of these medications might impact the respons...

    Authors: Daniel E. Leisman, Damian R. Handisides, Laurence W. Busse, Mark C. Chappell, Lakhmir S. Chawla, Michael R. Filbin, Marcia B. Goldberg, Kealy R. Ham, Ashish K. Khanna, Marlies Ostermann, Michael T. McCurdy, Christopher D. Adams, Tony N. Hodges and Rinaldo Bellomo
    Citation: Critical Care 2024 28:130
  32. Randomized data evaluating the impact of the extracorporeal cardiopulmonary resuscitation (ECPR) approach on long-term clinical outcomes in patients with refractory out-of-hospital cardiac arrest (OHCA) are la...

    Authors: Daniel Rob, Klaudia Farkasovska, Marketa Kreckova, Ondrej Smid, Petra Kavalkova, Jaromir Macoun, Michal Huptych, Petra Havrankova, Juraj Gallo, Jan Pudil, Milan Dusik, Stepan Havranek, Ales Linhart and Jan Belohlavek
    Citation: Critical Care 2024 28:125
  33. Extracorporeal Carbon Dioxide Removal (ECCO2R) is used in acute respiratory distress syndrome (ARDS) patients to facilitate lung-protective ventilatory strategies. Electrical Impedance Tomography (EIT) allows ind...

    Authors: Benjamin Pequignot, Alain Combes, Mickael Lescroart, Bruno Levy and Matthieu Koszutski
    Citation: Critical Care 2024 28:124
  34. To perform a systematic review with meta-analysis with the dual intent of assessing the impact of attaining aggressive vs. conservative beta-lactams PK/PD target on the clinical efficacy for treating Gram-nega...

    Authors: Milo Gatti, Pier Giorgio Cojutti and Federico Pea
    Citation: Critical Care 2024 28:123