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  1. High-flow nasal cannula oxygenation (HFNC) and noninvasive positive-pressure ventilation (NPPV) possibly decrease tracheal reintubation rates better than conventional oxygen therapy (COT); however, few large-s...

    Authors: Hideto Yasuda, Hiromu Okano, Takuya Mayumi, Chihiro Narita, Yu Onodera, Masaki Nakane and Nobuaki Shime

    Citation: Critical Care 2021 25:135

    Content type: Research

    Published on:

  2. Teleultrasound provides an effective solution to problems that arise from limited medical resources, a lack of local expertise, and scenarios where the risk of infection is high. This study aims to explore the...

    Authors: Shaobo Duan, Luwen Liu, Yongqing Chen, Long Yang, Ye Zhang, Shuaiyang Wang, Liuwei Hao and Lianzhong Zhang

    Citation: Critical Care 2021 25:134

    Content type: Research

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  3. 2-Deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) is an advanced imaging technique that can be used to examine the whole body for an infection focus in a single ...

    Authors: Jordy P. Pijl, Mark Londema, Thomas C. Kwee, Maarten W. N. Nijsten, Riemer H. J. A. Slart, Rudi A. J. O. Dierckx, Peter H. J. van der Voort, Andor W. J. M. Glaudemans and Janesh Pillay

    Citation: Critical Care 2021 25:133

    Content type: Research

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  4. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Mailis Maes, Ellen Higginson, Joana Pereira-Dias, Martin D. Curran, Surendra Parmar, Fahad Khokhar, Delphine Cuchet-Lourenço, Janine Lux, Sapna Sharma-Hajela, Benjamin Ravenhill, Islam Hamed, Laura Heales, Razeen Mahroof, Amelia Soderholm, Sally Forrest, Sushmita Sridhar…

    Citation: Critical Care 2021 25:130

    Content type: Correction

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    The original article was published in Critical Care 2021 25:25

  5. Limited data are available on the use of prone position in intubated, invasively ventilated patients with Coronavirus disease-19 (COVID-19). Aim of this study is to investigate the use and effect of prone posi...

    Authors: Thomas Langer, Matteo Brioni, Amedeo Guzzardella, Eleonora Carlesso, Luca Cabrini, Gianpaolo Castelli, Francesca Dalla Corte, Edoardo De Robertis, Martina Favarato, Andrea Forastieri, Clarissa Forlini, Massimo Girardis, Domenico Luca Grieco, Lucia Mirabella, Valentina Noseda, Paola Previtali…

    Citation: Critical Care 2021 25:128

    Content type: Research

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  6. Hemorrhagic events remain a major concern in patients under extracorporeal membrane oxygenation (ECMO) support. We tested the association between anticoagulation levels and hemorrhagic events under ECMO using ...

    Authors: Richard Descamps, Mouhamed D. Moussa, Emmanuel Besnier, Marc-Olivier Fischer, Sébastien Preau, Fabienne Tamion, Cédric Daubin, Nicolas Cousin, André Vincentelli, Julien Goutay and Damien Du Cheyron

    Citation: Critical Care 2021 25:127

    Content type: Research

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  7. Pulmonary artery thermodilution is the clinical reference method for cardiac output monitoring. Because both continuous and intermittent pulmonary artery thermodilution are used in clinical practice it is impo...

    Authors: Karim Kouz, Frederic Michard, Alina Bergholz, Christina Vokuhl, Luisa Briesenick, Phillip Hoppe, Moritz Flick, Gerhard Schön and Bernd Saugel

    Citation: Critical Care 2021 25:125

    Content type: Research

    Published on:

  8. The possible benefits associated with corticosteroid treatment in acute respiratory distress syndrome (ARDS) patients are not fully known. We conducted an updated meta-analysis to assess the effect of corticos...

    Authors: Ping Lin, Yuean Zhao, Xiaoqian Li, Faming Jiang and Zongan Liang

    Citation: Critical Care 2021 25:122

    Content type: Research

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  9. Although several international guidelines recommend early over late intubation of patients with severe coronavirus disease 2019 (COVID-19), this issue is still controversial. We aimed to investigate the effect...

    Authors: Eleni Papoutsi, Vassilis G. Giannakoulis, Eleni Xourgia, Christina Routsi, Anastasia Kotanidou and Ilias I. Siempos

    Citation: Critical Care 2021 25:121

    Content type: Research

    Published on:

  10. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Keyvan Razazi, Romain Arrestier, Anne Fleur Haudebourg, Brice Benelli, Guillaume Carteaux, Jean‑Winoc Decousser, Slim Fourati, Paul Louis Woerther, Frederic Schlemmer, Anais Charles-Nelson, Francoise Botterel, Nicolas de Prost and Armand Mekontso Dessap

    Citation: Critical Care 2021 25:118

    Content type: Correction

    Published on:

    The original article was published in Critical Care 2020 24:699

  11. Medical emergency teams (MET) are mostly led by physicians. Some hospitals are currently using nurse practitioners (NP) to lead MET calls. These are no studies comparing clinical outcomes between these two car...

    Authors: Sachin Gupta, Mayurathan Balachandran, Gaby Bolton, Naomi Pratt, Jo Molloy, Eldho Paul and Ravindranath Tiruvoipati

    Citation: Critical Care 2021 25:117

    Content type: Research

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  12. The mortality of critically ill patients with COVID-19 is high, particularly among those receiving mechanical ventilation (MV). Despite the high number of patients treated worldwide, data on respiratory mechan...

    Authors: Giacomo Grasselli, Emanuele Cattaneo, Gaetano Florio, Mariachiara Ippolito, Alberto Zanella, Andrea Cortegiani, Jianbo Huang, Antonio Pesenti and Sharon Einav

    Citation: Critical Care 2021 25:115

    Content type: Review

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  13. A recent randomised trial showed that recombinant thrombomodulin did not benefit patients who had sepsis with coagulopathy and organ dysfunction. Several recent studies suggested presence of clinical phenotype...

    Authors: Daisuke Kudo, Tadahiro Goto, Ryo Uchimido, Mineji Hayakawa, Kazuma Yamakawa, Toshikazu Abe, Atsushi Shiraishi and Shigeki Kushimoto

    Citation: Critical Care 2021 25:114

    Content type: Research

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  14. Septic shock is characterized by breakdown of the endothelial glycocalyx and endothelial damage, contributing to fluid extravasation, organ failure and death. Albumin has shown benefit in septic shock patients...

    Authors: Arianna Piotti, Deborah Novelli, Jennifer Marie Theresia Anna Meessen, Daniela Ferlicca, Sara Coppolecchia, Antonella Marino, Giovanni Salati, Monica Savioli, Giacomo Grasselli, Giacomo Bellani, Antonio Pesenti, Serge Masson, Pietro Caironi, Luciano Gattinoni, Marco Gobbi, Claudia Fracasso…

    Citation: Critical Care 2021 25:113

    Content type: Research

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  15. The availability of handheld, noninvasive sublingual video-microscopes allows for visualization of the microcirculation in critically ill patients. Recent studies demonstrate that reduced numbers of blood-perf...

    Authors: Alexandros Rovas, Jan Sackarnd, Jan Rossaint, Stefanie Kampmeier, Hermann Pavenstädt, Hans Vink and Philipp Kümpers

    Citation: Critical Care 2021 25:112

    Content type: Research

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  16. In COVID-19 patients with acute respiratory distress syndrome (ARDS), the effectiveness of ventilatory rescue strategies remains uncertain, with controversial efficacy on systemic oxygenation and no data avail...

    Authors: Chiara Robba, Lorenzo Ball, Denise Battaglini, Danilo Cardim, Emanuela Moncalvo, Iole Brunetti, Matteo Bassetti, Daniele R. Giacobbe, Antonio Vena, Nicolò Patroniti, Patricia R. M. Rocco, Basil F. Matta and Paolo Pelosi

    Citation: Critical Care 2021 25:111

    Content type: Research

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  17. In patients ventilated with tidal volume (Vt) < 8 mL/kg, pulse pressure variation (PPV) and, likely, the variation of distensibility of the inferior vena cava diameter (IVCDV) are unable to detect preload respons...

    Authors: Temistocle Taccheri, Francesco Gavelli, Jean-Louis Teboul, Rui Shi and Xavier Monnet

    Citation: Critical Care 2021 25:110

    Content type: Research

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  18. Galectin-3 (Gal-3) is a pleiotropic glycan-binding protein shown to be involved in sepsis and acute kidney injury (AKI). However, its role has never been elucidated in sepsis-associated AKI (S-AKI). We aimed t...

    Authors: Haibing Sun, Huiping Jiang, Amity Eliaz, John A. Kellum, Zhiyong Peng and Isaac Eliaz

    Citation: Critical Care 2021 25:109

    Content type: Research

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  19. Intensive care survivors often experience post-intensive care sequelae, which are frequently gathered together under the term “post-intensive care syndrome” (PICS). The consequences of PICS on quality of life,...

    Authors: Anne-Françoise Rousseau, Hallie C. Prescott, Stephen J. Brett, Björn Weiss, Elie Azoulay, Jacques Creteur, Nicola Latronico, Catherine L. Hough, Steffen Weber-Carstens, Jean-Louis Vincent and Jean-Charles Preiser

    Citation: Critical Care 2021 25:108

    Content type: Viewpoint

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  20. Single- (SL) and double-lumen (DL) catheters are used in clinical practice for veno-venous extracorporeal membrane oxygenation (V-V ECMO) therapy. However, information is lacking regarding the effects of the c...

    Authors: Roberto Lorusso, Mirko Belliato, Michael Mazzeffi, Michele Di Mauro, Fabio Silvio Taccone, Orlando Parise, Ayat Albanawi, Veena Nandwani, Paul McCarthy, Zachary Kon, Jay Menaker, Daniel M. Johnson, Sandro Gelsomino and Daniel Herr

    Citation: Critical Care 2021 25:107

    Content type: Research

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  21. Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory management of COVID-19-related acute respiratory f...

    Authors: Prashant Nasa, Elie Azoulay, Ashish K. Khanna, Ravi Jain, Sachin Gupta, Yash Javeri, Deven Juneja, Pradeep Rangappa, Krishnaswamy Sundararajan, Waleed Alhazzani, Massimo Antonelli, Yaseen M. Arabi, Jan Bakker, Laurent J. Brochard, Adam M. Deane, Bin Du…

    Citation: Critical Care 2021 25:106

    Content type: Research

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  22. Severe traumatic brain injury (TBI) is associated with blood–brain barrier (BBB) disruption and a subsequent neuroinflammatory process. We aimed to perform a multiplex screening of brain enriched and inflammat...

    Authors: Caroline Lindblad, Elisa Pin, David Just, Faiez Al Nimer, Peter Nilsson, Bo-Michael Bellander, Mikael Svensson, Fredrik Piehl and Eric Peter Thelin

    Citation: Critical Care 2021 25:103

    Content type: Research

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  23. Fluid overload has been associated with increased morbidity and mortality in critically ill patients. The goal of this study was to assess the efficacy and safety of a diuretic strategy to overcome positive fl...

    Authors: Raphaël Cinotti, Jean-Baptiste Lascarrou, Marie-Ange Azais, Gwenhaël Colin, Jean-Pierre Quenot, Pierre-Joachim Mahé, Antoine Roquilly, Aurélie Gaultier, Karim Asehnoune and Jean Reignier

    Citation: Critical Care 2021 25:98

    Content type: Research

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  24. The approach for veno-arterial extracorporeal membrane oxygenation implantation (VA-ECMO) in patients with cardiogenic shock can be either surgical or percutaneous. Complete angio-guided percutaneous implantat...

    Authors: Anne-Sophie Martin-Tuffreau, François Bagate, Madjid Boukantar, Gabriel Saiydoun, Andrea Mangiameli, Laura Rostain, Gauthier Mouillet, Antonio Fiore, Olivier Langeron, Armand Mekontso-Dessap, Nicolas Mongardon, Thierry Folliguet, Emmanuel Teiger and Romain Gallet

    Citation: Critical Care 2021 25:93

    Content type: Research

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  25. The use of indirect calorimetry (IC) is increasing due to its precision in resting energy expenditure (REE) measurement in critically ill patients. Thus, we aimed to evaluate the clinical outcomes of an IC-gui...

    Authors: Jing-Yi Duan, Wen-He Zheng, Hua Zhou, Yuan Xu and Hui-Bin Huang

    Citation: Critical Care 2021 25:88

    Content type: Research

    Published on:

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