From: Cytomegalovirus reactivation and associated outcome of critically ill patients with severe sepsis
 | Univariable analysis | Multivariable analysis | |||
---|---|---|---|---|---|
Factor | HR | P-v alue | HR | 95% CI | P-v alue |
CMV reactivation | 3.101 | 0.009 | 3.365 | 1.233 to 9.183 | 0.018 |
SAPS II at inclusion | 1.065 | <0.001 | 1.045 | 1.008 to 1.083 | 0.016 |
Septic Shock present | 2.282 | 0.081 | 1.486 | 0.535 to 4.127 | 0.447 |
ICU stay before enrolment | 1.006 | 0.577 | 1.020 | 0.996 to 1.044 | 0.104 |
HSV detection in respiratory secretions | 1.302 | 0.501 | 1.338 | 0.595 to 3.013 | 0.481 |
Optimized model | |||||
CMV reactivation | Â | Â | 2.441 | 1.011 to 5.897 | 0.047 |
SAPS II at inclusion | Â | Â | 1.055 | 1.020 to 1.091 | 0.002 |
Landmark analysis for Day 0, Day 7 and Day 14 | |||||
Day 0 (86 patients, 12 of them with CMV reactivation) | |||||
   CMV reactivation | 1.017 | 0.975 | 1.061 | 0.367 to 3.068 | 0.913 |
   SAPS II at inclusion | 1.065 | <0.001 | 1.065 | 1.030 to 1.101 | <0.001 |
Day 7 (64 patients, 16 of them with CMV reactivation) | |||||
   CMV reactivation | 2.274 | 0.112 | 2.853 | 1.003 to 8.117 | 0.049 |
   SAPS II at inclusion | 1.071 | 0.001 | 1.074 | 1.033 to 1.116 | <0.001 |
Day 14 (47 patients, 17 of them with CMV reactivation) | |||||
   CMV reactivation | 2.109 | 0.164 | 2.538 | 0.861 to 7.479 | 0.091 |
   SAPS II at inclusion | 1.065 | 0.010 | 1.069 | 1.021 to 1.120 | 0.004 |