Table 1 Baseline demographic and clinical characteristics in severely ill patients
Anidulafungin (n= 89) | Fluconazole (n= 74) | |
|---|---|---|
Age (years), mean (SD) | 60.2 (16.4) | 62.2 (16.4) |
APACHE II score, mean (SD) | 18.0 (7.0) | 17.3 (6.8) |
Gender, n (%) | ||
Male | 45 (50.6) | 41 (55.4) |
Female | 44 (49.4) | 33 (44.6) |
Race, n (%) | ||
White | 65 (73.0) | 59 (79.7) |
Black | 19 (21.3) | 9 (12.2) |
Other | 5 (5.6) | 6 (8.1) |
Absolute neutrophil count, n (%) | ||
≤ 500 | 3 (3.4) | 4 (5.4) |
> 500 | 86 (96.6) | 70 (94.6) |
Risk factors for candidemia, n (%) | ||
Central venous catheter | 71 (79.8) | 58 (78.4) |
Broad-spectrum antibiotics | 65 (73.0) | 53 (71.6) |
Recent surgery | 37 (41.6) | 34 (45.9) |
Recent hyperalimentation (TPN) | 25 (28.1) | 16 (21.6) |
Malignancy | 23 (25.8) | 16 (21.6) |
Immunosuppressive therapy | 14 (15.7) | 19 (25.7) |
Transplant | 5 (5.6) | 4 (5.4) |
Source of isolates, n (%) | ||
Candidemia | 85 (95.5) | 69 (93.2) |
Intra-abdominal infection | 4 (4.5) | 5 (6.8) |
Candida spp., n (%) | ||
Single isolate | 81 (91.0) | 69 (93.2) |
C. albicans | 45 (50.6) | 43 (58.1) |
C. glabrata | 15 (16.9) | 14 (18.9) |
C. parapsilosis | 10 (11.2) | 4 (5.4) |
C. tropicalis | 9 (10.1) | 6 (8.1) |
Mixed | 8 (9.0) | 5 (6.8) |