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Table 1 Comparison of baseline characteristics of patients with and without sepsis

From: Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study

 

Patients

with sepsis

(N= 606)

Patients

without sepsis

(N= 819)

P-value

Total cohort

(N= 1425)

28-day mortality n (%)

135 (22.3%)

36 (4.4%)

< 0.001

171 (12.0%)

Gender (male) n (%)

385 (63.5%)

508 (62%)

0.56

893 (62.7%)

Age (y.o, IQR)

67 (55, 75)

65 (54, 73)

0.015

66 (54, 74)

APACHE II score (IQR)

21 (16, 25)

14 (10, 18)

< 0.001

17 (12, 22)

Mechanical ventilation requirement n (%)

429 (70.8%)

528 (64.5%)

0.01

957 (67.2%)

Postoperative admission n (%)

68 (11.2%)

538 (65.7%)

< 0.001

602 (42.2%)

Reasons for admission n (%)

    

   Cardiac or vascular disease

109 (18.0%)

435 (53.1%)

< 0.001

544 (38.2%)

   Thoracic or respiratory disease

343 (56.6%)

205 (25.0%)

< 0.001

548 (38.4%)

   Renal or metabolic disease

61 (10.0%)

54 (6.6%)

0.018

115 (8.1%)

   Gastrointestinal tract disease

68 (11.2%)

108 (13.1%)

0.26

176 (12.4%)

   Other

25 (4.1%)

17 (2.1%)

0.024

42 (2.9%)

Length of stay in ICU

8 (5, 14)

5 (4, 7)

< 0.001

6 (4, 10)

MAX ICU (°C, IQR)

38.3 (37.7, 39.0)

37.8 (37.4, 38.3)

< 0.001

38.0 (37.5, 38.6)

   < 36.5°C

4 (0.7%)

2 (0.2%)

0.43

6 (0.4%)

   36.5°C to 37.4°C

98 (16.2%)

240 (29.3%)

< 0.001

338 (23.7%)

   37.5°C to 38.4°C

237 (39.1%)

425 (52.0%)

< 0.001

662 (46.5%)

   38.5°C to 39.4°C

185 (30.5%)

125 (15.3%)

< 0.001

310 (21.8%)

   ≥ 39.5°C

82 (13.5%)

27 (3.3%)

< 0.001

109 (7.6%)

NSAIDs

    

   Number of patients administered n (%)

31 (5.1%)

99 (12.1%)

< 0.001

130 (9.1%)

   Delta body temperature* (°C, IQR)

-0.3 (-0.8, 0.0)

-0.4 (-0.7, 0.0)

0.57

-0.3 (-0.7, 0.0)

Acetaminophen

    

   Number of patients administered n (%)

116 (19.1%)

32 (3.9%)

< 0.001

148 (10.4%)

   Delta body temperature* (°C, IQR)

-0.4 (-0.8, -0.2)

-0.3 (-0.7, 0.0)

0.14

-0.4 (-0.9, -0.2)

Physical cooling

    

   Number of patients administered n (%)

307 (50.7%)

364 (44.4%)

0.02

671 (47.1%)

   Delta body temperature* (°C, IQR)

-0.2 (-0.5, 0.0)

-0.1 (-0.3, 0.0)

< 0.001

-0.1 (-0.3, 0.0)

  1. APACHE, Acute Physiology and Chronic Health Evaluation; IQR, 25%, 75% interquartile; MAXICU, maximum body temperature during ICU stay; NSAIDs, non-steroid anti-inflammatory drugs
  2. *, Delta body temperature from application of antipyretic to next temperature monitoring
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