Table 2 Time-adjusted mean arterial pressure (MAP) and vasoactive treatments divided by progression of acute kidney injury
Progression of AKI | No progression of AKI | P-value | |
|---|---|---|---|
N = 153 | N = 270 | ||
Time-adjusted MAP | 74.4 (68.3 to 80.8) | 78.6 (72.9 to 85.4) | <0.001 |
Time-adjusted MAP below 73 mmHg (%) | 69 (45.1) | 68 (25.2) | <0.001 |
Aggregate time below MAP thresholds, minutes | |||
55 mmHg | 0.0 (0.0 to 10.0) | 0.0 (0.0 to 10.0) | 0.02 |
60 mmHg | 10.0 (0.0 to 70.0) | 5.0 (0.0 to 30.0) | 0.007 |
65 mmHg | 80.0 (10.0 to 280.0) | 50.0 (0.0 to 160.0) | 0.02 |
70 mmHg | 290.0 (80.0 to 620.0) | 180.0 (40.0 to 480.0) | 0.02 |
75 mmHg | 600.0 (235.0 to 985.0) | 490.0 (160.0 to 870.0) | 0.15 |
80 mmHg | 770.0 (445.0 to 1140.0) | 750.0 (287.5 to 1102.5) | 0.35 |
85 mmHg | 910.0 (660.0 to 1260.0) | 1015.0 (567.5 to 1270.0) | 0.86 |
Time adjusted aggregate time below MAP thresholds, % | |||
55 mmHg | 0.0 (0.0 to 1.1) | 0.0 (0.0 to 0.7) | 0.01 |
60 mmHg | 1.1 (0.0 to 7.2) | 0.4 (0.0 to 2.5) | 0.002 |
65 mmHg | 7.7 (0.8 to 27.3) | 3.6 (0.0 to 11.2) | 0.002 |
70 mmHg | 25.4 (7.0 to 59.5) | 14.8 (3.4 to 34.6) | <0.001 |
75 mmHg | 56.9 (23.0 to 81.9) | 37.3 (12.2 to 65.3) | <0.001 |
80 mmHg | 76.3 (43.5 to 95.0) | 56.5 (24.7 to 80.7) | <0.001 |
85 mmHg | 93.1 (65.5 to 97.9) | 75.8 (45.8 to 92.8) | <0.001 |
Norepinephrine, n (%) | 131 (85.6) | 180 (66.7) | >0.001 |
Max dose ≤24 h in ICU (μg/kg/minute) | 0.19 (0.07 to 0.42) | 0.08 (0.00 to 0.19) | <0.001 |
Max dose 1 to 5 d in ICU (μg/kg/minute) | 0.24 (0.11 to 0.50) | 0.14 (0.08 to 0.30) | <0.001 |
Epinephrine, n (%) | 5 (3.3) | 2 (0.7) | 0.1 |
Max dose ≤24 h in ICU (μg/kg/minute) | 0.02 (0.02 to 0.02) | 0.14 (0.02 to 0.66) | 0.31 |
Max dose 1 to 5 d in ICU (μg/kg/minute) | 0.15 (0.02 to 0.15) | 0.14 (0.06 to 0.78) | 0.8 |
Dopamine, n (%) | 2 (1.3) | 2 (0.7) | 0.62 |
Max dose ≤24 h in ICU (μg/kg/minute) | 5.0 (2.7 to 5.0) | 9.1 (5.56 to 9.1) | 0.13 |
Max dose 1 to 5 d in ICU (μg/kg/minute) | 5.0 (2.7 to 5.0) | 9.1 (5.56 to 9.1) | 0.13 |
Vasopressor load max (μg/kg/minute) | |||
≤24 h in ICU | 0.32 (0.15 to 0.85) | 0.14 (0.08 to 0.29) | <0.001 |
1 to 5 d in ICU | 0.40 (0.22 to 0.96) | 0.15 (0.08 to 0.30) | <0.001 |
Vasopressin, n (%) | 4 (2.6) | 1 (0.4) | 0.06 |
Dobutamine, n (%) | 33 (21.6) | 15 (5.6) | <0.001 |
Levosimendan, n (%) | 11 (7.2) | 4 (1.5) | <0.002 |
Milrinone, n (%) | 4 (2.6) | 1 (0.4) | 0.06 |