Model | Simple | Reproducible | Complete control over external factors | Graded response easily achieved | Tubular | Medullary | Inflammator y1 | Functional injury and pathology correlate | Matches human pathology | Matches clinical scenario | Clinical Relevance |
---|---|---|---|---|---|---|---|---|---|---|---|
Warm ischaemia2 | + | + | + | + | + | + | + | ± | |||
Isolated perfused kidney | + | + | + | + | ± | ||||||
Radio contrast | + | + | + | + | + | + | + | + | |||
Combined insults | + | + | + | ± | ± | + | + | ||||
Gentamicin | + | + | ± | ± | + | + | |||||
Cisplatin3 | + | + | + | + | + | ± | |||||
Glycerol4 | + | + | + | + | + | ||||||
Myoglobin/haemaglobin | + | + | |||||||||
Endotoxin | + | + | + | + | |||||||
Bacterial infusion (iv) | + | + | + | ||||||||
Bacterial infusion (ip) | + | + | + | ||||||||
Caecal perforation | + | + | + | + |