Parameter | Overall | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 |
---|---|---|---|---|---|---|
Remifentanil | n = 64 | n = 58 | n = 33 | n = 26 | n = 21 | n = 20 |
Mean time to neurological assessment,a h | 0.41 | 0.35 | 0.45 | 0.46 | 0.78 | 0.81 |
Between-patient variability | 0.44 | 0.35 | 0.47 | 1.35 | 0.30 | 0.42 |
Fentanyl | n = 32 | n = 32 | n = 13 | n = 11 | n = 7 | n = 8 |
Mean time to neurological assessment,a h | 0.71 | 0.69 | 0.67 | 0.92 | 1.63 | 1.83 |
Mean ratio (95% CI) | 1.74 (1.26, 2.41) | 1.98 (1.44, 2.72) | 1.48 (0.73, 3.01) | 2.01 (0.93, 4.33) | 2.09 (1.33, 3.30) | 2.27 (1.39, 3.73) |
Remifentanil versus fentanyl | P = 0.001 | P < 0.001 | P = 0.274 | P = 0.074 | P = 0.003 | P = 0.002 |
Between-patient variability | 0.86 | 0.86 | 3.01 | 0.51 | 0.13 | 0.10 |
Ratio of variability (95% CI) | 1.96 (1.01, 3.45) | 2.45 (1.37, 4.79) | 6.41 (2.83, 19.9) | 0.38 (0.15, 1.34) | 0.45 (0.16, 2.61) | 0.24 (0.08, 1.16) |
Remifentanil versus fentanyl | P = 0.024 | P = 0.003 | P < 0.001 | P = 0.109 | P = 0.333 | P = 0.059 |
Morphine | n = 34 | n = 31 | n = 20 | n = 10 | n = 3 | n = 2 |
Mean time to neurological assessmenta, h | 0.82 | 0.79 | 0.70 | 1.01 | 1.28 | 1.86 |
Mean ratio (95% CI) | 2.01 (1.44, 2.81) | 2.25 (1.60, 3.15) | 1.53 (0.93, 2.52) | 2.19 (0.98, 4.86) | 1.65 (0.84, 3.25) | 2.31 (0.87, 6.13) |
Remifentanil versus morphine | P < 0.001 | P < 0.001 | P = 0.091 | P = 0.055 | P = 0.139 | P = 0.088 |
Between-patient variability | 0.98 | 1.03 | 1.27 | 0.48 | 0.12 | 0.02 |
Ratio of variability (95% CI) | 2.24 (1.28, 4.28) | 2.93 (1.63, 5.80) | 2.71 (1.27, 6.58) | 0.35 (0.14, 1.37) | 0.41 (0.13, 23.0) | 0.06 (0.02, 112.6) |
Remifentanil versus morphine | P = 0.006 | P = 0.001 | P = 0.012 | P = 0.108 | P = 0.659 | P = 0.381 |