Table 4 Arterial lactate; systemic and regional lactate/pyruvate ratios; regional lactate exchange
From: Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function
Group | Baseline | 1.5 hours | 3 hours | 6 hours | 12 hours | End of experiment | |
|---|---|---|---|---|---|---|---|
Arterial lactate (mmol/l) | Endotoxic | 0.8 (0.4–1.2) | 1.0 (0.5–1.3) | 0.9 (0.7–1.7) | 0.9 (0.7–1.1) | 0.8 (0.5–1.0) | 0.9 (0.6–4.2) |
Control | 0.9 (0.7–1.2) | 0.7 (0.5–1.2) | 0.7 (0.5–1) | 0.7 (0.5–1.0) | 0.5 (0.4–0.8) | 0.5 (0.3–1.1) | |
Systemic lactate/pyruvate ratio | Endotoxic | 9.4 (6.7–17.0) | 9.5 (7.1–18.3) | 11.0 (6.7–23.7) | 8.9 (7.5–14.1) | 9.5 (6.6–10.4) | 11.9 (8.5–27.1)a |
Control | 9.5 (5.7–13.6) | 8.1 (5.4–10.0) | 8.7 (7.1–10.9) | 8.7 (7.2–11.3) | 8.5 (5.4–11.8) | 7.3 (5.6–11.6) | |
Hepatic lactate/pyruvate ratio | Endotoxic | 9.7 (7.3–27.6) | 10.3 (5.7–19.8) | 10.7 (6.9–18.6) | 9.4 (6.2–18.1) | 7.9 (6.2–16.7) | 12.1 (7.5–33.0) |
Control | 12.4 (3.9–46.9) | 9.2 (4.5–26.7) | 9.9 (6.7–34.9) | 8.2 (5.4–28.3) | 7.0 (4.9–30.8) | 9.2 (5.8–25.3) | |
Renal lactate/pyruvate ratio | Endotoxic | 8.0 (6.0–10.0) | 8.4 (5.5–35.9) | 9.8 (6.6–12.5) | 8.0 (5.4–15.7) | 7.4 (6.3–9.8) | 8.1 (7.3–33.6) |
Control | 8.7 (6.5–11.0) | 7.9 (5.7–13.1) | 8.6 (6.1–14.4) | 8.7 (5.2–36.1) | 7.3 (5.8–37.3) | 8.7 (5.3–14.2) | |
Renal lactate exchange (μmol/minute) | Endotoxic | 1.4 (–1.5–2.1) | 1.0 (–12.1–1.6) | 0.9 (–3.2–2.4) | 0.6 (–0.9–1.2) | 0.8 (–0.7–2.6) | 1.1 (–7.8–2.4) |
Control | 0.7 (–3.5–1.6) | 0.1 (–4.5–1.5) | 0.3 (–1.7–1.3) | 0.6 (–11.1–1.3) | 0.5 (–9.9–1.5) | 0.3 (–1.5–1.4) | |
Hepatic lactate exchange (μmol/kg/minute) | Endotoxic | 9.0 (5.2–20.1) | 8.7 (–11.0–22.4) | 9.7 (7.4–21.3) | 11.6 (9.6–19.0) | 12.7 (6.5–18.6) | 10.8 (–17.5–15.2) |
Control | 10.3 (0.8–18.2) | 9.0 (5.9–15.0) | 8.6 (3.8–19.0) | 7.3 (4.7–16.9) | 9.2 (3.5–16.7) | 9.4 (5.2–16.7) |