Influenza | RSV | SARS-CoV | VZV | Adenovirus | CMV | VHF | |
---|---|---|---|---|---|---|---|
Virus family | Orthomyxovirdae | Paramyxovirdae | Coronaviridae | Herpesvirdae | Adenoviridae | Herpesviridae | Filoviridae |
Epidemiologic link | Seasonal epidemic | Seasonal epidemic, immunocompromised and transplant | Laboratory exposure on known infected individual | Contact with infected individual | Military camps, mental health facilities | Transplantation, immunosuppressive medications | Endemic area or contact with infected individual |
Pulmonary clinical findings | Primary Alveolar Pneumonia | Upper respiratory tract infection, bronchiolitis, pneumonia | Rapid progressive pneumonia, ARDS | Primary alveolar pneumonia | Alveolar pneumonia with bronchiolitis | Interstitial pneumonitis, bronchiolitis | Alveolar edema |
Lipid envelope | Yes | Yes | Yes | Yes | No | Yes | Yes |
Major receptor for cell entry | Sialic acid | RSV glycoprotein G | CD209L ACE 2 | Glycoprotein C and D | Coksackie-adenovirus receptor | Unknown, involves integrens | Folate receptor Alpha |
Primary cell of infection | Type 1 respiratory epithelium | Type 1 respiratory epithelium | Type 1 respiratory epithelium | Macrophage and dendritic cells | Type 1 respiratory epithelium | Multiple | Macrophages and dendritic cells |
Viremia | No | No | Yes | Yes | Yes | Yes | Yes |
Primary host immunity | Humoral | Humoral | Unknown | Cellular | Cellular | Cellular | Humoral |