Acute pancreatitis with organ dysfunction associates with abnormal blood lymphocyte signaling: controlled laboratory study

Table 3 p38 signaling

Stimulation		TNF	LPS	MDP
FI (RFU) of pp38 Ly	Healthy subject	2.5 ± 0.1	1.9 ± 0.1	1.9 ± 0.1
	Patient	3.4 ± 0.5*	2.1 ± 0.1	2.0 ± 0.1
% of pp38 positive Ly	Healthy subject	18.4 ± 2.3	3.4 ± 0.3	3.4 ± 0.4
	Patient	22.1 ± 2.9	4.8 ± 0.6	3.2 ± 0.3
FI (RFU) of pp38 positive Ly	Healthy subject	6.4 ± 0.3	5.5 ± 0.4	5.1 ± 0.4
	Patient	7.1 ± 0.6	6.6 ± 1.2	7.3 ± 1.8
Stimulation		*E. coli*	*S. aureus*	*S. epidermidis*
FI (RFU) of pp38 Ly	Healthy subject	2.0 ± 0.1	2.1 ± 0.1	2.1 ± 0.1
	Patient	2.7 ± 0.2**	2.9 ± 0.3*	2.2 ± 0.1
% of pp38 positive Ly	Healthy subject	8.3 ± 0.9	6.1 ± 0.6	6.9 ± 0.7
	Patient	15.6 ± 1.8**	16.0 ± 3.5*	5.4 ± 0.9
FI (RFU) of pp38 positive Ly	Healthy subject	6.3 ± 1.0	5.2 ± 0.4	5.1 ± 0.3
	Patient	6.9 ± 0.7	7.5 ± 1.1	7.3 ± 1.3

FI, fluorescence intensity; LPS, lipopolysaccharide; Ly, lymphocytes; MDP, N-acetylmuralyl-alanyl-D-isoglutamine; TNF-α, tumor necrosis factor-α. N = 9 to 10, *P < 0.05, **P < 0.01 as compared to healthy subject

ISSN: 1364-8535