Inclusion criteria: | Exclusion criteria: |
---|---|
○ Ischaemic or haemorrhagic stroke | ○ Severe cardiac insufficiency (NYHA ≥ III) |
â—‹ ICP/temperature brain probe | â—‹ Acute myocardial infarction or pulmonary embolism |
○ Indication for therapeutic cooling independent of the study | ○ Threatened ventricular dysrhythmia or cardiac dysrhythmia (heart rate <50/min, QTc >450 ms, sick sinus syndrome, AV block II-III°) |
â—‹ Sedation, intubation, and mechanical ventilation | â—‹ Chronic sinusitis or current or past fracture or surgery of the paranasal sinuses not allowing secure application of nasopharyngeal cooling |
○ Age ≥18 years | ○ Severe infection with bacteraemia or sepsis ≥72 h |
○ Written informed consent by patient or legal representative | ○ Fever >38.5°C |
â—‹ Severe renal or liver insufficiency | |
â—‹ Known haematologic disease with increased risk of thrombosis (e.g., cryoglobulinaemia, cold agglutinins or sickle cell anaemia) | |
â—‹ Known vasospastic vascular disorder (e.g., Raynaud phenomenon or thromboangiitis obliterans) | |
â—‹ Body weight >120 kg |