Algorithm-guided goal-directed haemodynamic therapy does not improve renal function after major abdominal surgery compared to good standard clinical care: a prospective randomised trial

Table 4 Comparison of achievement rates between intervention groups and between surgery and intensive care unit

		Control	GDT	Control vs. GDT		OP vs. ICU
		Control	GDT	Median diff. (95 % CI)	p value	Median diff. (95 % CI)	p value
Pulse contour data
MAP > 70 mmHg	OP	0.85	0.77	−0.06	0.010	0.08	< 0.001
	OP	(0.33 – 1.0)	(0.33 – 0.99)	(−0.11 to −0.02)	0.010	(0.05 to 0.12)
	ICU	0.91	0.90	0.00	0.74
	ICU	(0.10 – 1.0)	(0.29 – 1.0)	(−0.03 to 0.02)	0.74
CI > 2.5 l/min/m²	OP	0.82	0.75	−0.04	0.20	0.23	< 0.001
	OP	(0.01 – 1.0)	(0.06 – 1.0)	(−0.10 to 0.02)	0.20	(0.18 to 0.27)
	ICU	0.99	0.97	0.00	0.12
	ICU	(0.72 - 1.0)	(0.59 – 1.0)	(−0.02 to 0.00)	0.12
Thermodilution data
CI > 2.5 l/min/m²	OP	0.79	0.71	−0.04	0.22	0.27	< 0.001
	OP	(0.0 – 1.0)	(0.0 – 1.0)	(−0.13 to 0.00)	0.22	(0.23 to 0.31)
	ICU	1.0	1.0	0.00	0.18
	ICU	(0.56 – 1.0)	(0.50 – 1.0)	(0.00 to 0.00)	0.18
GEDI > 640 ml/m²	OP	0.90	1.0	0.00	0.70	0.22	0.001
	OP	(0.0 – 1.0)	(0.0 – 1.0)	(0.00 to 0.00)	0.70	(0.00 to 0.71)
	ICU	1.0	1.0	0.00	0.18
	ICU	(0.0 – 1.0)	(0.0 – 1.0)	(0.00 to 0.00)	0.18
ELWI ≤ 10 ml/kg	OP	1.00	1.00	0.00	0.06	0.00	0.012
	OP	(0.0 – 1.0)	(0.0 – 1.0)	(0.00 to 0.00)	0.06	(0.00 to 0.00)
	ICU	1.00	1.00	0.00	0.10
	ICU	(0.13 – 1.0)	(0.0 – 1.0)	(0.00 to 0.00)	0.10

Variables are given as median of the ratio the respective parameter was within the target range relating to the complete observation period and range (minimum to maximum); continuous data is haemodynamic data saved every 12 seconds with the integrated recording system. Pulse contour data is haemodynamic data acquired whenever thermodilution was performed
GDT goal-directed haemodynamic therapy, OP operation, ICU intensive care unit, diff. difference, CI confidence interval, MAP mean arterial pressure; CI cardiac index; GEDI global end-diastolic index; ELWI extravascular lung water index

ISSN: 1364-8535