Table 5 Multivariate linear regression analysis of factors influencing change of creatinine clearance

Fluid [= HES]

48 %

−8.2

(−15.7 to −0.7)

0.033

Sex [= male]

77 %

1.7

(−7.0 to 10.4)

0.697

Age (year)

66 (64 to 67)

−0.4

(−0.8 to 0.0)

0.054

BMI (kg/m²)

22 (21 to 22)

−1.8

(−2.7 to −0.8)

< 0.001

Preoperative creatinine clearance (ml/min/1.73 m²)

87 (83 to 91)

−0.4

(−0.6 to −0.2)

< 0.001

MAP > 70 mmHg (achievement rate during whole operation period)

0.77 (0.74 to 0.80)

27.9

(5.9 to 49.8)

0.013

MAP > 70 mmHg (achievement rate during whole ICU observation)

0.85 (0.83 to 0.88)

19

(−2.4 to 41)

0.081

CI > 2.5 l/min/m² (achievement rate during whole operation period)

0.70 (0.66 to 0.74)

−5.8

(−22 to 10)

0.477

CI > 2.5 l/min/m² (achievement rate during whole ICU observation)

0.95 (0.94 to 0.96)

16.7

(−36.6 to 70.1)

0.536

Noradrenaline infusion rate^a during operation (μg/kg/min)

0.03 (0.02 to 0.04)

−42

(−111 to 26)

0.222

Noradrenaline infusion rate^a during ICU (μg/kg/min)

0.02 (0.01 to 0.03)

−60

(−126 to 5.6)

0.073

Dobutamine infusion rate^a during operation (μg/kg/min)

0.40 (0.07 to 0.73)

1.4

(−0.9 to 3.8)

0.227

Dobutamine infusion rate^a during ICU (μg/kg/min)

0.17 (0.02 to 0.32)

−1.7

(−5.6 to 2.2)

0.389

GEDI > 640 ml/m² (achievement rate during whole operation period)

0.74 (0.69 to 0.79)

−9.2

(−26.9 to 8.4)

0.302

GEDI > 640 ml/m² (achievement rate during whole ICU observation)

0.80 (0.76 to 0.85)

20

(2.3 to 37)

0.027

ELWI < 11 ml/kg (achievement rate during whole operation period)

0.89 (0.86 to 0.93)

15

(−1.8 to 31)

0.079

ELWI < 11 ml/kg (achievement rate during whole ICU observation)

0.93 (0.90 to 0.96)

−3.2

(−24 to 18)

0.764