Quality assessment | Patients, number | Effect | Quality | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Studies, number | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | PPIs | H2RAs | Relative (95Â % CI) | Absolute (95Â % CI) | |
Clinically important bleeding | ||||||||||
14 | Seriousa | Not serious | Not serious | Not seriousb | None | 13/986 (1.3 %) | 39/693 (5.6 %) | RR 0.39 (0.21, 0.71) | 15 fewer per 1000 (7–20 fewer) | Moderatea,b |
Overt upper gastrointestinal bleeding | ||||||||||
17 | Seriousa | Not seriousc | Not serious | Not serious | None | 53/1102 (4.8 %) | 118/795 (14.8 %) | RR 0.48 (0.34, 0.66) | 26 fewer per 1000 (17–33 fewer) | Moderatea,c |
Nosocomial pneumonia | ||||||||||
13 | Seriousa | Not seriousd | Not serious | Seriouse | None | 119/862 (13.8Â %) | 92/709 (13.0Â %) | RR 1.12 (0.86, 1.46) | 16 more per 1000 (18 fewer to 60 more) | Lowa,d,e |
Mortality | ||||||||||
11 | Not seriousf | Not serious | Not serious | Seriouse | None | 151/874 (17.3Â %) | 120/614 (19.5Â %) | RR 1.05 (0.87, 1.27) | 10 more per 1000 (25 fewer to 53 more) | Moderatee,f |
ICU length of stay | ||||||||||
7 | Seriousg | Not serious | Not serious | Serioush | None | 371 | 373 | - | MD 0.58Â days fewer (2.03 fewer to 0.86 more) | Lowg,h |