Table 7 The main studies describing the effectiveness/limitations of LPS adsorbers
| Â | Yaroustovsky et al. 2009 [60] | Ala-Kokko et al. 2011 [61] | Adamik et al. 2015 [62] |
|---|---|---|---|
Study design | Observational | Case series with matched controls | Observational |
Study population (n) | 13 Gram-negative sepsis | 24 septic shock patients and endotoxaemia. | 62 septic shock and suspected Gram-negative |
EAA assessment | – | More than 0.3 considered endotoxaemia | EA [0.70 EA units (0.66–0.77)]. |
Prescribed dose | Two sessions with a maximum duration of 120 min/patient Alteco adsorber (n = 6) and toraymyxin (n = 7) | 2-h LPS HP | LPS elimination + ST vs ST 1–2 sessions |
Timing | – | Within 36 h | Within 24 h |
Survival | – | – | No effect |
Length of ICU stay | – | – | No effect |
Hemodynamics | Improved MAP | Decreased VP | Significant improvement in the treatment group |
Other results | Decrease in endotoxin and procalcitonin levels | Decreased endotoxin levels | Decreased endotoxin levels |
Safety | Â | Low platelets, two patients requiring transfusion but no bleeding | Â |