A | ||||||||
Baseline (T1) | During PLR (T2) | Baseline (T3) | After VE (T4) | Group R/NR | Study period | R/NRstudy period | ||
CRT, s | CRT-R (n = 15) | 3.6 [2.8, 6.0] | 2.3 [1.6, 3.6] | NA | 2.1 [1.8, 2.9]* | < 0.001 | 0.972 | < 0.001 |
CRT-NR (n = 19) | 2.6 [2.3, 3.3] | 2.6 [2.0, 3.1] | NA | 2.6 [2.0, 3.1] | ||||
CI, L min−1 m−2 | CRT-R (n = 15) | 2.5 [2.0, 3.1] | 2.8 [2.5, 3.3] | 2.5 [2.1, 3.2] | 3.0 [2.7, 3.2] | 0.987 | < 0.001 | 0.829 |
CRT-NR (n = 19) | 2.5 [2.2, 3.1] | 2.8 [2.5, 3.5] | 2.4 [2.1, 3.3] | 3.1 [2.6, 3.4] | ||||
SVi, mL m−2 | CRT-R (n = 15) | 31 [24, 35] | 34 [27, 37] | 30 [24, 36] | 33 [30, 40] | 0.787 | 0.001 | 0.997 |
CRT-NR (n = 19) | 27 [22, 35] | 31 [30, 37] | 27 [21, 36] | 32 [27, 36] | ||||
HR, min−1 | CRT-R (n = 15) | 96 [73.0, 104] | 97 [72, 105] | 96 [73, 106] | 93 [70, 105]* | 0.700 | 0.674 | 0.537 |
CRT-NR (n = 19) | 93 [78, 112] | 94 [78, 110] | 95 [79, 110] | 91 [80, 108] | ||||
SAP, mmHg | CRT-R (n = 15) | 97 [90, 116] | 116 [102, 136] | 107 [94, 132.] | 118 [105, 136] | 0.624 | 0.477 | 0.554 |
CRT-NR (n = 19) | 104 [94, 116] | 112 [99, 116] | 98 [94, 110] | 112 [104, 119] | ||||
DAP, mmHg | CRT-R (n = 15) | 52 [46, 57] | 53 [46, 64] | 49 [43, 54] | 57 [45, 66] | 0.958 | 0.524 | 0.249 |
CRT-NR (n = 19) | 51 [41, 56] | 51 [47, 56] | 51 [46, 54] | 51 [46, 57] | ||||
MAP, mmHg | CRT-R (n = 15) | 70 [62, 75.] | 71 [65, 82] | 68 [60, 73] | 76 [69, 81] | 0.714 | 0.101 | 0.932 |
CRT-NR (n = 19) | 67 [61, 70] | 67 [63, 76.] | 64 [58, 70] | 68. [63, 75] | ||||
PP, mmHg | CRT-R (n = 15) | 49 [36, 65.] | 55 [46, 83] | 58 [44, 83] | 60 [46, 75] | 0.321 | 0.051 | 0.548 |
CRT-NR (n = 19) | 53 [41, 64] | 56 [49, 63] | 51 [44, 58] | 58 [50, 72] | ||||
SpO2, % | CRT-R (n = 15) | 98 [97, 100] | 99 [97, 100] | 99 [97, 100] | 100 [97, 100] | 0.353 | 0.143 | 0.575 |
CRT-NR (n = 19) | 99 [95,100] | 98 [95, 100] | 97 [93, 100] | 99 [96, 100] | ||||
EtCO2, mmHg | CRT-R (n = 15) | 34 [32, 44] | 36 [32, 45] | 34 [30, 43] | 34 [29.7, 45.5] | 0.708 | 0.175 | 0.548 |
CRT-NR (n = 19) | 37 [31, 46] | 36 [32, 44] | 35 [30, 43] | 36 [31, 43] | ||||
CVP, mmHg | CRT-R (n = 15) | 8 [7, 11] | 11 [9, 14] | 8 [6, 11] | 10 [7, 13] | 0.678 | 0.906 | 0.543 |
CRT-NR (n = 19) | 6 [3, 9] | 7 [5, 12] | 5 [2, 8] | 6 [4, 9] | ||||
B | ||||||||
Baseline (T1) | After VE (T4) | p value | ||||||
Oxygen delivery, mL min−1 m−2 | CRT-R (n = 14) | 313 [254–361] | 370 [317–399] | 0.002 | ||||
CRT-NR (n = 14) | 355 [309–440] | 397 [327–458] | 0.003 | |||||
p value | 0.24 | 0.697 | ||||||
Oxygen uptake, mL min−1 m−2 | CRT-R (n = 14) | 103 [88–109] | 100 [90–109] | 0.357 | ||||
CRT-NR (n = 14) | 97 [64–119] | 104 [80–133] | 0.375 | |||||
p value | 0.401 | 0.697 | ||||||
Oxygen extraction ratio | CRT-R (n = 14) | 0.34 [0.26–0.40] | 0.28 [0.22–0.33] | 0.024 | ||||
CRT-NR (n = 14) | 0.28 [0.23–0.30] | 0.24 [0.19–0.33] | 0.583 | |||||
p value | 0.051 | 0.608 |