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Table 4 NEWS and MR-proADM values upon ED presentation and 72 h within patient subgroups

From: Biomarkers and clinical scores to identify patient populations at risk of delayed antibiotic administration or intensive care admission

Patient subgroups

Patient populations stratified by NEWS and MR-proADM

MR-proADM (nmol/L)

NEWS (points)

MR-proADM (nmol/L)

NEWS (points)

MR-proADM (nmol/L)

NEWS (points)

MR-proADM (nmol/L)

NEWS (points)

< 1.77

< 5

≥ 1.77

< 5

< 1.77

≥ 5

≥ 1.77

≥ 5

Population, N (%)

425 (62.1%)

74 (10.8%)

100 (14.6%)

85 (12.8%)

Infection related 28-day mortality, N (%)

0 (0.0%)

10 (13.5%)

6 (6.0%)

14 (16.5%)

NEWS: surviving patients

 ED admission (points)

1.72 (1.29)

2.18 (1.39)

7.18 (1.71)

7.97 (2.62)

 72 h (points)

1.54 (1.62)

2.08 (2.26)

4.57 (3.22)

3.61 (2.48)

p value

0.182

0.784

< 0.001

< 0.001

NEWS: non-surviving patients

 ED admission (points)

NA

2.60 (0.97)

6.20 (1.10)

8.36 (2.69)

 72 h (points)

NA

2.63 (2.07)

4.20 (2.03)

4.90 (3.31)

p value

NA

0.875

< 0.05

< 0.05

MR-proADM: surviving patients

 ED admission (nmol/L)

0.88 (0.36)

2.78 (1.16)

1.23 (0.34)

3.39 (1.47)

 72 h (nmol/L)

0.91 (0.58)

1.80 (1.11)

1.08 (0.50)

2.13 (1.36)

p value

0.56

< 0.001

< 0.01

< 0.001

MR-proADM: non-surviving patients

 ED admission (nmol/L)

NA

3.22 (1.37)

1.30 (0.29)

2.77 (1.38)

 72 h (nmol/L)

NA

3.95 (1.02)

1.41 (0.35)

3.69 (2.49)

p value

NA

0.085

0.548

0.148

  1. All NEWS and MR-proADM values are expressed as mean (standard deviation). MR-proADM mid-regional proadrenomedullin, N number, NEWS National Early Warning Score