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Fig. 1 | Critical Care

Fig. 1

From: Plasma levels of soluble ACE2are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-19

Fig. 1

The associations of plasma sACE2 levels with sex, age, and metabolic syndrome (MetS). a Sex differences in plasma sACE2 levels. b Differences in sACE2 levels between pre- (N = 272) and post-menopausal (N = 251) women over 35 years of age. c Associations between sACE2 and age. d Differences in sACE2 levels in individuals who do vs. who do not meet diagnostic criteria for MetS and its subcomponents. The following diagnostic criteria, based on WHO guidelines, were used: obesity, BMI > 30 kg/m2; hyperglycemia, fasting glucose > 100 mg/dl or other evidence of insulin resistance (e.g., prescription); hypertension, systolic/diastolic blood pressure ≥ 140/90 mm/hg; dyslipidemia, triglycerides > 150 or HDL-C < 35 for men and < 39 for women. Overall status was determined as MetS if the individual met criteria for insulin resistance and satisfied at least one other domain criterion for the syndrome. sACE2, soluble ACE2 (normalized protein expression, NPX, values adjusted for covariates and scaled)

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Critical Care

ISSN: 1364-8535