Reliability of biomarkers of sepsis during extracorporeal therapies: the clinician needs to know what is eliminated and what is not

Table 1 Biomarker molecular weight, potential removal by CRRT or sorbents, and summary of the available studies and the studies that need to be realized of levels in the context of RRT

Biomarker	Molecular weight (kDa)	Elimination by CRRT	Elimination by sorbents	Existing studies	Studies needed
mCRP	20–25	+	+	+	+
PCT	14.5	+	+	+	+
BNP	3.5	+	+	+	+
NT-ProBNP	8.5	+	+	+	+
HMGB-1	25	+ (adsorption only)	+	+	–
OPN		–	+	–	+
Endocan	40	–	+	–	+
MR-pro-ADM	4–5.5	+	–	–	+
PTX3	35	–	+	+	+
Presepsin	13	+	+	+	+
HBP	37	–	+	–	+

kDa kilodalton, CRRT continuous renal replacement therapy, mCRP monomeric C-reactive protein, PCT procalcitonin, NT-ProBNP N-terminal pro-hormone of brain natriuretic peptide, OPN osteopontin, HMGB-1 high mobility group protein B1, MR-pro-ADM mid-regional pro-adrenomedullin, HBP heparin binding protein

ISSN: 1364-8535