Table 1 Baseline characteristics and values of markers of lung injury in survivor versus non-survivors
Variables | Survivors (n = 20) | Non-survivors (n = 11) | p value |
|---|---|---|---|
Age, years | 61 ± 6 | 68 ± 6 | 0.05 |
Male, sex, no. % | 17 (85) | 9 (82) | 0.59 |
BMI, Kg/m2 | 27.8 ± 4.1 | 28.9 ± 3.2 | 0.41 |
SAPS II at ICU admission | 27 [21–38] | 31 [21–37] | 0.55 |
SOFA score at ICU admission | 4 [2–5] | 5 [3–6] | 0.23 |
Length of ICU stay (days) | 31 [25–43] | 24 [16–31] | 0.04 |
Comorbidities | |||
Hypertension, no. (%) | 9 (45) | 8 (73) | 0.13 |
Dyslipidemia, no. (%) | 4 (20) | 1 (9) | 0.40 |
Former smoker, no. (%) | 4 (20) | 6 (54) | 0.06 |
Diabetes, no. (%) | 4 (20) | 1 (9) | 0.40 |
COPD, no. (%) | 2 (5) | 2 (18) | 0.45 |
Chronic kidney disease, no. (%) | 3 (15) | 5 (45) | 0.08 |
Laboratory data at inclusion | |||
White blood cells, × 103/L | 9.8 [7.5–12.9] | 10.2 [8.8–12.7] | 0.85 |
Lymphocytes, × 103/L | 965 [640–1167] | 680 [560–980] | 0.18 |
Hemoglobin, g/dL | 12.1 ± 1.8 | 13.1 ± 1.1 | 0.11 |
Platelets count, × 103/L | 286 [265–386] | 286 [195–332] | 0.43 |
apTT, seconds | 39 ± 5 | 37 ± 5 | 0.34 |
INR | 1.1 ± 0.1 | 1.1 ± 0.1 | 0.35 |
Fibrinogen mg/dL | 708 [655–888] | 786 [532–862] | 0.87 |
D-dimer, mcg/mL | 31 [14–42] | 36 [19–57] | 0.31 |
IL-6, pg/mL | 84 [17–149] | 60 [37–145] | 0.73 |
Respiratory variables at admission | |||
PaO2/ FiO2 ratio | 183 [124–264] | 116 [81–184] | 0.045 |
PaCO2, mmHg | 48 [36–56] | 48 [41–69] | 0.40 |
VT/PDW, mL | 6.0 ± 0.5 | 6.0 ± 0.5 | 0.96 |
Driving Pressure, cmH2O | 9 [8–11] | 8 [7–14] | 0.79 |
Compliance Respiratory System | 57 [36–78] | 60 [51–64] | 0.95 |
Plateau pressure, cmH2O | 18 [15–21] | 21 [18–23] | 0.11 |
PEEP setting (cmH2O) | 12 [9–12] | 10 [8–11] | 0.07 |