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Table 3 Patients’ characteristics by tertiles of VE-cadherin on day 1

From: Endothelial damage in septic shock patients as evidenced by circulating syndecan-1, sphingosine-1-phosphate and soluble VE-cadherin: a substudy of ALBIOS

VE-cadherin (ng/mL)

Lowest tertile

range: 528–1475

(125)

Middle tertile

range:1483–1985

(123)

Highest tertile

range:1988–7487

(127)

P*

SYN-1 (ng/mL)

     

 Day 1

Median [IQR]

111 [77–262]

191 [87–384]

286 [140–655]

2.5 × 10–8

 Day 2

Median [IQR]

339 [200–723]

471 [252–820]

550 [287–1470]

4.1 × 10–5

 Day 7

Median [IQR]

408 [242–763]

459 [283–899]

555 [285–1270]

0.04

S1P (ng/mL)

     

 Day 1

Median [IQR]

83 [63–116]

87.4 [63.7–119.2]

88.1 [64.0–121.6]

0.72

 Day 2

Median [IQR]

82 [62–120]

89.2 [68.0–118.9]

91.7 [74.0–130.5]

0.11

 Day 7

Median [IQR]

89 [62–119]

94.2 [72.5–136.2]

92.5 [71.0–139.2]

0.09

Sex

     

 Female

No. (%)

60 (48.0%)

57 (46.3%)

47 (37.0%)

0.17

Age (year)

Mean ± SD

70.6 ± 12.5

69.1 ± 13.6

66.2 ± 14.9

0.05

BMI (kg/m2)

Mean ± SD

26.9 ± 6.5

26.1 ± 4.9

27.0 ± 5.6

0.39

Mean arterial pressure (mmHg)

Mean ± SD

72.9 ± 12.7

74.2 ± 12.6

71.8 ± 13.9

0.20

Heart rate (bpm)

Mean ± SD

104 ± 21

106 ± 25

106 ± 19

0.76

Urine output (mL/h)

Median[IQR]

65 [30–100]

60 [ 30–120]

50 [28–100]

0.55

Hemoglobin (g/dL)

Mean ± SD

11.2 ± 1.8

10.9 ± 1.8

11.0 ± 1.6

0.55

PaO2/FiO2

Median[IQR]

203 [129–267]

200 [132–295]

201 [141–288]

0.71

Venous oxygen saturation (%)

Mean ± SD

72.4 ± 9.7

74.5 ± 8.4

73.6 ± 9.9

0.24

Central venous pressure (mmHg)

Mean ± SD

10.6 ± 4.2

10.8 ± 5.3

11.1 ± 4.5

0.75

Ventilatory support needed

No. (%)

116 (92.8%)

106 (86.2%)

110 (86.6%)

0.19

Cardiovascular pathologies

No. (%)

18 (14.4%)

22 (17.9%)

27 (21.3%)

0.364

Hepatic insufficiency

No. (%)

4 (3.2%)

1 (0.8%)

1 (0.8%)

0.22

Immunocompromised

No. (%)

17 (13.6%)

12 (9.8%)

19 (15.0%)

0.45

Renal Insufficiency

No. (%)

0

2 (1.6%)

6 (4.7%)

0.03

COPD

No. (%)

16 (12.8%)

15 (12.2%)

14 (11.0%)

0.91

Baseline SOFA

score > 2

     

 Cardiovascular

No. (%)

125 (100%)

123 (100%)

127 (100%)

-

 Coagulation

No. (%)

3 (2.4%)

9 (7.3%)

20 (15.9%)

0.001

 Liver

No. (%)

0

3 (2.6%)

8 (6.7%)

0.01

 Kidney

No. (%)

24 (19.4%)

28 (23.1%)

32 (25.6%)

0.50

 Respiratory

No. (%)

54 (44.3%)

56 (46.3%)

56 (44.4%)

0.94

Dead at 90 days

No. (%)

40 (32.0%)

43 (35.0%)

58 (45.7%)

0.06

  1. SYN-1, syndecan-1; S1P, sphingosine 1-phosphate; IQR, interquartile range; SD, standard deviation; BMI, body mass index; COPD, chronic obstructive pulmonary disease; SOFA, sequential organ failure assessment
  2. *p value for Kruskal–Wallis or Chi2 to compare VE-cadherin tertiles
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Critical Care

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