The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Table 3 Multivariable model assessing predictors of in-hospital mortality (N = 619 patients)

Variable	Odds ratio (95% CI)	p value
Age, years	1.01 (1.01 to 1.02)	< 0.001
Sex, male	1.04 (0.96 to 1.12)	0.34
Hypertension	1.01 (0.94 to 1.09)	0.83
Chronic respiratory disease	1.16 (1.03 to 1.29)	0.013
SOFA hemodynamic component	1.01 (0.99 to 1.03)	0.53
PaO₂/F_iO₂ ratio at ICU admission, mmHg	1.00 (0.99 to 1.00)	0.14
Serum creatinine at ICU admission, mg/dL	1.09 (1.03 to 1.15)	0.003
Lymphocyte count at ICU admission, × 10⁹/L	1.00 (0.98 to 1.03)	0.89
Platelet count at ICU admission, × 10⁹/L	1.00 (1.00 to 1.00)	0.12
Total bilirubin at ICU admission, mg/dL	0.97 (0.91 to 1.03)	0.27
D-dimers at ICU admission, μg/L	1.00 (1.00 to 1.00)	0.29
Ventilatory ratio at ICU admission	1.07 (1.01 to 1.14)	0.016

Mixed-effects model with centers as a random effect and considering a binomial distribution. AUC statistic (area under the curve) is 0.79 (95% CI 0.76 to 0.83), and Brier score is 0.18. P-values marked in bold indicate numbers that are significant on the 95% confidence limit. CI confidence interval; FiO₂, fraction of inspired oxygen; ICU, intensive care unit; PaO₂, partial pressure of arterial oxygen; SOFA, sequential organ failure assessment score

ISSN: 1364-8535