Table 1 Baseline characteristics of patients
From: Hyperoxemia in postsurgical sepsis/septic shock patients is associated with reduced mortality
PaO2 ≤ 100 mmHg (1) (n = 238) | PaO2 > 100 mmHg (2) (n = 216) | p value (1 vs. 2) | |
|---|---|---|---|
Characteristics | |||
Age [years, median [IQR]] | 73 [14] | 72 [16] | 0.69 |
Male [%, (n)] | 65.5 (156) | 54.6 (118) | 0.028 |
Comorbidities [% (n)] | |||
Chronic cardiovascular disease | 34.9 (83) | 27.8 (60) | 0.09 |
Chronic respiratory disease | 22.3 (53) | 12.5 (27) | 0.005 |
High blood pressure | 59.7 (142) | 54.6 (118) | 0.22 |
Chronic renal failure | 8.4 (20) | 9.7 (21) | 0.66 |
Chronic hepatic failure | 3.3 (8) | 4.2 (9) | 0.67 |
Diabetes mellitus | 22.7 (54) | 22.2 (48) | 0.86 |
Cancer | 27.3 (65) | 39.4 (85) | 0.008 |
Immunosuppression | 4.6 (11) | 3.7 (8) | 0.61 |
Obesity | 18.5 (44) | 11.1(24) | 0.024 |
Surgery type, [% (n)] | |||
Abdominal | 60.9 (145) | 76.4 (165) | 0.009 |
Cardio-thoracic | 2.9 (7) | 3.2 (7) | 0.98 |
Vascular | 6.3 (15) | 3.2 (7) | 0.07 |
Urological/renal | 2.1 (5) | 2.3 (5) | 0.99 |
Other | 4.6 (11) | 2.3 (5) | 0.12 |
Source of infection, [% (n)] | |||
Respiratory tract | 32.9 (73) | 16.3 (33) | < 0.001 |
Abdomen | 50.0 (111) | 61.9 (125) | 0.014 |
Urinary tract | 3.4 (8) | 4.6 (10) | 0.50 |
Surgical site | 0.8 (2) | 1.4 (3) | 0.58 |
Bacteremia | 3.8 (9) | 3.2 (7) | 0.74 |
Other | 11.3 (27) | 11.6 (25) | 0.96 |
Microbiology, [% (n)] | |||
Gram + | 29.4 (70) | 29.2 (63) | 0.95 |
Gram − | 38.2 (91) | 31.0 (67) | 0.11 |
Fungi | 16.4 (39) | 10.6 (23) | 0.08 |
Measurements at diagnosis [median [IQR]] | |||
PaO2 (mmHg) | 74.15 [25] | 134 [45] | < 0.001 |
FiO2 | 0.50 [0.05] | 0.50 [0] | 0.47 |
PaO2/FiO2 ratio (mmHg) | 157.64 [73.45] | 278 [108.50] | < 0.001 |
PaO2 at 48 h (mmHg) | 71.50 [25] | 131 [45] | < 0.001 |
Total bilirubin (mg/dl) | 0.89 [1.06] | 0.75 [0.82] | 0.12 |
Glucose (mg/dl) | 168 [76.15] | 171 [75.25] | 0.82 |
Creatinine (mg/dl) | 1.90 [2.51] | 1.51 [1.73] | 0.001 |
Na (mmol/L) | 137 [6] | 136 [5] | 0.024 |
K (mmol/L) | 4 [1.1] | 4 [1] | 0.54 |
Platelet count (cells/mm3) | 173,000 [155500] | 197,000 [184000] | 0.014 |
Lactate (mmol/L) | 2.66 [2.17] | 2.20 [2.20] | 0.08 |
Procalcitonin (ng/ml) | 5.50 [16.28] | 5.05 [23.41] | 0.61 |
C-Reactive Protein (mg/L) | 250.55 [176.50] | 232 [155.40] | 0.039 |
White Blood cells (cells/mm3) | 13,660 [12295] | 12,955 [10521] | 0.06 |
Lymphocytes (cells/mm3) | 961.65 [988.14] | 767.70 [901.52] | 0.003 |
Neutrophils (cells/mm3) | 11,727.31 [11263.94] | 11,308.80 [9629.29] | 0.16 |
Urgent surgery | 66.4 (158) | 80.1 (173) | 0.001 |
SOFA score | 9 [3] | 7 [5] | < 0.001 |
APACHE II score | 16 [7] | 14 [7] | < 0.001 |
Time course and outcome | |||
Length of hospital stay [days, median (IQR)] | 25 [24] | 23.50 [27] | 0.97 |
Length of ICU stay [days, median (IQR)] | 8 [13] | 5 [9] | < 0.001 |
Length of mechanical ventilation [days, median (IQR)] | 2 [8] | 1 [4] | < 0.001 |
Sepsis [% (n)] | 16.0 (38) | 32.9 (71) | < 0.001 |
Septic shock [% (n)] | 84.0 (200) | 67.1 (145) | < 0.001 |
Mortality at 90 days [% (n)] | 37.0 (88) | 25.5 (55) | 0.008 |