Table 3 Sequelae of survivors according to the IMV delay
ALL | Early IMV | Delayed IMV | p value | N | |
|---|---|---|---|---|---|
n = 111 Median [IQR] or n (%) | n = 81 Median [IQR] or n (%) | n = 30 Median [IQR] or n (%) | |||
Pulmonary function | |||||
FVC, % | 79.6 [65.9; 88.3] | 79.3 [67.2; 88.0] | 80.1 [63.0; 89.8] | 0.849 | 109 |
FEV1, % | 86.1 [73.2; 96.1] | 85.8 [74.2; 95.0] | 87.8 [70.6; 100] | 0.879 | 108 |
FEV1 to FVC ratio | 0.83 [0.81; 0.86] | 0.83 [0.80; 0.86] | 0.84 [0.82; 0.87] | 0.156 | 103 |
FEV1 to FVC ratio > 0.7 | 102 (99.0%) | 77 (100%) | 25 (96.2%) | 0.252 | 103 |
TLC, % mean (sd) | 81.1 [71.1; 88.0] | 81.8 [66.2; 87.7] | 78.4 [73.1; 88.1] | 0.952 | 99 |
TLC, % | 0.553 | 99 | |||
< 50% | 5 (5.05%) | 3 (4.11%) | 2 (7.69%) | ||
≤ 50–80% | 53 (53.5%) | 41 (56.2%) | 12 (46.2%) | ||
≥ 80% | 41 (41.4%) | 29 (39.7%) | 12 (46.2%) | ||
RV % | 81.0 [66.0; 101] | 85.0 [65.9; 102] | 74.5 [69.5; 94.9] | 0.484 | 99 |
DLCO, mL/min/mm Hg mean (sd) | 65.0 [55.0; 74.6] | 68.4 [57.3; 76.7] | 60.0 [51.5; 64.5] | 0.010 | 107 |
DLCO, mL/min/mm Hg | 0.246 | 107 | |||
< 60% | 36 (33.6%) | 23 (29.1%) | 13 (46.4%) | ||
≤ 60–80% | 53 (49.5%) | 41 (51.9%) | 12 (42.9%) | ||
≥ 80% | 18 (16.8%) | 15 (19.0%) | 3 (10.7%) | ||
6MWT | |||||
Distance, m | 395 [320; 440] | 395 [320; 430] | 390 [325; 460] | 0.825 | 104 |
Oxygen saturation, % | |||||
Initial | 97.0 [96.0; 97.0] | 97.0 [96.0; 98.0] | 96.0 [96.0; 97.0] | 0.005 | 104 |
Final | 96.0 [94.0; 96.0] | 96.0 [94.0; 96.0] | 95.0 [93.0; 96.0] | 0.080 | 104 |
Average | 96.0 [94.0; 96.0] | 96.0 [94.0; 96.0] | 95.0 [94.0; 97.0] | 0.598 | 104 |
Minimal | 94.0 [92.0; 96.0] | 94.0 [92.0; 96.0] | 94.0 [92.0; 95.0] | 0.281 | 104 |
Chest CT scan findings | |||||
Density | |||||
Ground glass | 50 (46.3%) | 36 (45.6%) | 14 (48.3%) | 0.974 | 108 |
Mixed ground glass | 50 (46.3%) | 29 (36.7%) | 21 (72.4%) | 0.002 | 108 |
Consolidation | 22 (20.4%) | 14 (17.7%) | 8 (27.6%) | 0.391 | 108 |
Internal structures | |||||
Interlobular septal thickening | 93 (86.1%) | 66 (83.5%) | 27 (93.1%) | 0.346 | 108 |
Bronchiectasis | 89 (82.4%) | 64 (81.0%) | 25 (86.2%) | 0.731 | 108 |
Atelectasis | 31 (28.7%) | 25 (31.6%) | 6 (20.7%) | 0.381 | 108 |
Solid nodule | 44 (40.7%) | 29 (36.7%) | 15 (51.7%) | 0.235 | 108 |
Nonsolid nodule | 3 (2.78%) | 2 (2.53%) | 1 (3.45%) | 1.000 | 108 |
Lesions | 0.004 | 108 | |||
Reticular | 45 (41.7%) | 39 (49.4%) | 6 (20.7%) | ||
Fibrotic | 43 (39.8%) | 24 (30.4%) | 19 (65.5%) | ||
None | 20 (18.5%) | 16 (20.3%) | 4 (13.8%) | ||
Number of lobes affected | 5.00 [2.00; 5.00] | 4.00 [2.00; 5.00] | 5.00 [5.00; 5.00] | < 0.001 | 108 |
Total severity score | 7.00 [3.00; 10.0] | 6.00 [2.00; 9.50] | 10.0 [7.00; 12.0] | < 0.001 | 108 |